Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM189867'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM189867 (US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-...) Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O |r| Show InChI InChI=1S/C27H23N5O3S/c1-16-11-19(14-20(12-16)29-26-30-23-6-2-3-10-32(23)31-26)22-15-28-25(36-22)27(35)9-4-5-17-13-18(24(33)34)7-8-21(17)27/h2-3,6-8,10-15,35H,4-5,9H2,1H3,(H,29,31)(H,33,34)/t27-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.129	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9670196 (2017) BindingDB Entry DOI: 10.7270/Q2D798MJ
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