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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM205257'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205257
PNG
(US9249125, 10)
Show SMILES Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CN5CCCC5=O)c4)C(C)(C)C)c4ccccc34)n2)cc2cn[nH]c12
Show InChI InChI=1S/C41H40N10O3/c1-25-19-28(21-27-23-43-48-38(25)27)44-39-42-17-16-36(47-39)54-33-15-14-32(30-11-5-6-12-31(30)33)45-40(53)46-35-22-34(41(2,3)4)49-51(35)29-10-7-9-26(20-29)24-50-18-8-13-37(50)52/h5-7,9-12,14-17,19-23H,8,13,18,24H2,1-4H3,(H,43,48)(H,42,44,47)(H2,45,46,53)
PDB
MMDB

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US Patent
n/an/a 2n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair