Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM255485'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255485 (US10828301, Compound R926816 | US9499493, R926816) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C21H20FN5O4/c1-23-19(28)12-31-15-4-2-3-13(9-15)26-21-24-11-16(22)20(27-21)25-14-5-6-17-18(10-14)30-8-7-29-17/h2-6,9-11H,7-8,12H2,1H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	61.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020) BindingDB Entry DOI: 10.7270/Q2F47S6W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255485 (US10828301, Compound R926816 | US9499493, R926816) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1 Show InChI InChI=1S/C21H20FN5O4/c1-23-19(28)12-31-15-4-2-3-13(9-15)26-21-24-11-16(22)20(27-21)25-14-5-6-17-18(10-14)30-8-7-29-17/h2-6,9-11H,7-8,12H2,1H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	61.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair