Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM255518'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255518 ((+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenox...) Show SMILES COC1=CCCC(Nc2ncc(F)c(Nc3ccc4OC(C)CNc4c3)n2)=C1NC(C)=O |c:29,t:2| Show InChI InChI=1S/C22H25FN6O3/c1-12-10-24-17-9-14(7-8-18(17)32-12)27-21-15(23)11-25-22(29-21)28-16-5-4-6-19(31-3)20(16)26-13(2)30/h6-9,11-12,24H,4-5,10H2,1-3H3,(H,26,30)(H2,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
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