Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM255525'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255525 (N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...) Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)=C1 |c:6,36| Show InChI InChI=1S/C23H26FN7O4/c1-12-5-6-13(9-16(12)34-11-18(32)25-4)27-22-26-10-14(24)19(31-22)28-17-8-7-15-20(29-17)30-21(33)23(2,3)35-15/h7-10H,5-6,11H2,1-4H3,(H,25,32)(H3,26,27,28,29,30,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
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