Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM302005'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302005 (US9598405, 2.4) Show SMILES Cc1cc(Nc2cc(ccn2)-c2cn(C)nn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O Show InChI InChI=1S/C24H25N7O3S/c1-14-9-17(19-12-26-23(35-19)24(34)6-3-15(4-7-24)22(32)33)27-21(10-14)28-20-11-16(5-8-25-20)18-13-31(2)30-29-18/h5,8-13,15,34H,3-4,6-7H2,1-2H3,(H,32,33)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.808	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
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