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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50123570'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50123570
PNG
(CHEMBL3622698)
Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F |r|
Show InChI InChI=1/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/s2
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n/an/a 9n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50123570
PNG
(CHEMBL3622698)
Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F |r|
Show InChI InChI=1/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/s2
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n/an/a 107n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50123570
PNG
(CHEMBL3622698)
Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F |r|
Show InChI InChI=1/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 230n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair