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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50249416'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249416
PNG
(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4S/c1-9-6-10(15(16,17)18)8-11(7-9)21-14-20-3-2-12(22-14)13-19-4-5-23-13/h2-8H,1H3,(H,20,21,22)
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PC cid
PC sid
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110n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249416
PNG
(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4S/c1-9-6-10(15(16,17)18)8-11(7-9)21-14-20-3-2-12(22-14)13-19-4-5-23-13/h2-8H,1H3,(H,20,21,22)
PDB
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PC sid
UniChem
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Syk (unknown origin)


Bioorg Med Chem Lett 19: 1944-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.049
BindingDB Entry DOI: 10.7270/Q2WM1D98
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249416
PNG
(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4S/c1-9-6-10(15(16,17)18)8-11(7-9)21-14-20-3-2-12(22-14)13-19-4-5-23-13/h2-8H,1H3,(H,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)-mediated FCepsilonRI signaling activity by mast cell degranulation assay


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair