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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50276064'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276064
PNG
(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)
Show SMILES Cc1cnc(s1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-9-12(3)21-15/h4-9H,1-3H3,(H,17,19,20)
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MMDB

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PC cid
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Article
PubMed
23n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276064
PNG
(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)
Show SMILES Cc1cnc(s1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-9-12(3)21-15/h4-9H,1-3H3,(H,17,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)-mediated FCepsilonRI signaling activity by mast cell degranulation assay


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair