BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11' and Ligand = 'BDBM50391109'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens)	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Jiao Tong University (SJTU) Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin) using pNPP as substrate after 30 mins				Eur J Med Chem 164: 408-422 (2019) Article DOI: 10.1016/j.ejmech.2018.12.032 BindingDB Entry DOI: 10.7270/Q2KK9G90
Shanghai Jiao Tong University (SJTU) Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens)	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yanbian University College of Pharmacy Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SHP2 (catalytic domain 1116 to 2162 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as subst...				Eur J Med Chem 172: 163-173 (2019) Article DOI: 10.1016/j.ejmech.2019.03.059 BindingDB Entry DOI: 10.7270/Q2028VWB
Yanbian University College of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assay				Bioorg Med Chem Lett 27: 5154-5157 (2017) Article DOI: 10.1016/j.bmcl.2017.10.059 BindingDB Entry DOI: 10.7270/Q2PK0JP8
Jiangnan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens)	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127170 BindingDB Entry DOI: 10.7270/Q2NP27ZM
Jiangnan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens)	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin)				Eur J Med Chem 166: 178-185 (2019) Article DOI: 10.1016/j.ejmech.2019.01.057 BindingDB Entry DOI: 10.7270/Q2BR8WM5
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins				Bioorg Med Chem 23: 7079-88 (2015) Article DOI: 10.1016/j.bmc.2015.09.024 BindingDB Entry DOI: 10.7270/Q2QZ2CTV
Qilu University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology (Shandong Academy of Sciences) Curated by ChEMBL					Assay Description Inhibition of human GST-tagged SHP2 (1116 to 2162 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrate				Eur J Med Chem 144: 692-700 (2018) Article DOI: 10.1016/j.ejmech.2017.12.064 BindingDB Entry DOI: 10.7270/Q23B62P2
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin) using pNPP as substrate				Bioorg Med Chem 23: 4891-8 (2015) Article DOI: 10.1016/j.bmc.2015.05.032 BindingDB Entry DOI: 10.7270/Q28917N0
Qilu University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin) using pNPP as substrate by spectrophotometry				Bioorg Med Chem 23: 38-45 (2014) Article DOI: 10.1016/j.bmc.2014.11.031 BindingDB Entry DOI: 10.7270/Q20K2B5M
Nanchang University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens)	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yanbian University Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin) using pNPP as substrate				Bioorg Med Chem Lett 29: 1187-1193 (2019) Article DOI: 10.1016/j.bmcl.2019.03.023 BindingDB Entry DOI: 10.7270/Q2CR5XN6
Yanbian University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University					Assay Description IC50 values were determined by pNPP assay.				Bioorg Med Chem Lett 24: 1889-94 (2014) Article DOI: 10.1016/j.bmcl.2014.03.015 BindingDB Entry DOI: 10.7270/Q2PC3122
Jiangnan University					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50391109 (CHEMBL179166 \| Sodium orthovanadate (SOV) \| Vanada...) Show SMILES [O-][V]([O-])([O-])=O Show InChI InChI=1S/4O.V/q;3*-1;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.09E+5	n/a	n/a	n/a	n/a	n/a	n/a
Liaoning Normal University Curated by ChEMBL					Assay Description Inhibition of SHP2 (unknown origin)				Bioorg Med Chem Lett 24: 4125-8 (2014) Article DOI: 10.1016/j.bmcl.2014.07.055 BindingDB Entry DOI: 10.7270/Q2MP54XR
Liaoning Normal University Curated by ChEMBL					More data for this Ligand-Target Pair