BindingDB PrimarySearch

Found 16 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 2' and Ligand = 'BDBM50346601'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant TCPTP using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance base...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128422 BindingDB Entry DOI: 10.7270/Q2V4104X
TBA					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tohoku Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of full length recombinant N-terminal GST-tagged human TCPTP expressed in Escherichia coli using pNPP as substrate preincubated for 10 min...				Bioorg Med Chem Lett 27: 1159-1161 (2017) Article DOI: 10.1016/j.bmcl.2017.01.071 BindingDB Entry DOI: 10.7270/Q2ST7S23
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113511 BindingDB Entry DOI: 10.7270/Q2MS3XQV
TBA					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University					Assay Description IC50 values were determined by pNPP assay.				Bioorg Med Chem Lett 24: 1889-94 (2014) Article DOI: 10.1016/j.bmcl.2014.03.015 BindingDB Entry DOI: 10.7270/Q2PC3122
Jiangnan University					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yanbian University Curated by ChEMBL					Assay Description Inhibition of TCPTP (unknown origin) using pNPP as substrate				Bioorg Med Chem Lett 29: 1187-1193 (2019) Article DOI: 10.1016/j.bmcl.2019.03.023 BindingDB Entry DOI: 10.7270/Q2CR5XN6
Yanbian University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University Curated by ChEMBL					Assay Description Inhibition of GST-tagged TCPTP (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay				Bioorg Med Chem Lett 27: 5154-5157 (2017) Article DOI: 10.1016/j.bmcl.2017.10.059 BindingDB Entry DOI: 10.7270/Q2PK0JP8
Jiangnan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University Curated by ChEMBL					Assay Description Inhibition of GST-tagged TCPTP (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127170 BindingDB Entry DOI: 10.7270/Q2NP27ZM
Jiangnan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology Curated by ChEMBL					Assay Description Inhibition of TCPTP (unknown origin) assessed as pNPP hydrolysis after 30 mins				Bioorg Med Chem 23: 4891-8 (2015) Article DOI: 10.1016/j.bmc.2015.05.032 BindingDB Entry DOI: 10.7270/Q28917N0
Qilu University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology Curated by ChEMBL					Assay Description Inhibition of human TCPTP using pNPP as substrate incubated for 30 mins				Eur J Med Chem 118: 27-33 (2016) Article DOI: 10.1016/j.ejmech.2016.04.014 BindingDB Entry DOI: 10.7270/Q2JS9SCC
Qilu University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology Curated by ChEMBL					Assay Description Inhibition of TCPTP (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins				Bioorg Med Chem 23: 7079-88 (2015) Article DOI: 10.1016/j.bmc.2015.09.024 BindingDB Entry DOI: 10.7270/Q2QZ2CTV
Qilu University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology (Shandong Academy of Sciences) Curated by ChEMBL					Assay Description Inhibition of human TCPTP using pNNP as substrate after 30 mins				Eur J Med Chem 144: 692-700 (2018) Article DOI: 10.1016/j.ejmech.2017.12.064 BindingDB Entry DOI: 10.7270/Q23B62P2
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yanbian University College of Pharmacy Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged TCPTP (catalytic domain 41 to 1075 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substr...				Eur J Med Chem 172: 163-173 (2019) Article DOI: 10.1016/j.ejmech.2019.03.059 BindingDB Entry DOI: 10.7270/Q2028VWB
Yanbian University College of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
East China Normal University Curated by ChEMBL					Assay Description Inhibition of GST-tagged human TCPCP expressed in Escherichia coli using pNPP as substrate				Bioorg Med Chem Lett 27: 1105-1108 (2017) Article DOI: 10.1016/j.bmcl.2016.11.055 BindingDB Entry DOI: 10.7270/Q2W66P1R
East China Normal University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang Sci-Tech University Curated by ChEMBL					Assay Description Inhibition of TCPTP (unknown origin) assessed as reduction in nitrophenol production using pNPP as substrate incubated for 30 mins by EnVisionMultila...				Bioorg Med Chem Lett 29: 2358-2363 (2019) Article DOI: 10.1016/j.bmcl.2019.06.011 BindingDB Entry DOI: 10.7270/Q2280C4B
Zhejiang Sci-Tech University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Liaoning Normal University Curated by ChEMBL					Assay Description Inhibition of TCPTP (unknown origin)				Bioorg Med Chem Lett 24: 4125-8 (2014) Article DOI: 10.1016/j.bmcl.2014.07.055 BindingDB Entry DOI: 10.7270/Q2MP54XR
Liaoning Normal University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50346601 (NSC-114945 \| OLEANOLIC_ACID \| Oleanolic acid \| Ole...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of human TCPTP as hydrolysis of pNPP after 2 mins				Bioorg Med Chem Lett 26: 778-81 (2016) Article DOI: 10.1016/j.bmcl.2015.12.097 BindingDB Entry DOI: 10.7270/Q2K939CS
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair