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Target
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Compile Data Set for Download or QSAR
Found
4
hits Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase 7' and Ligand = 'BDBM50436151'
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Ubiquitin carboxyl-terminal hydrolase 7
(Homo sapiens (Human))
BDBM50436151
(CHEMBL2398212)
Show SMILES
Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
Show InChI
InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
n/a
n/a
400
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7
(Homo sapiens (Human))
BDBM50436151
(CHEMBL2398212)
Show SMILES
Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
Show InChI
InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
420
n/a
n/a
n/a
n/a
n/a
n/a
Kumamoto University
Curated by
ChEMBL
Assay Description
Inhibition of USP7 (unknown origin) using ubiquitin-EKL as substrate
Bioorg Med Chem Lett
23:
3884
-
6
(2013)
Article DOI:
10.1016/j.bmcl.2013.04.066
BindingDB Entry DOI:
10.7270/Q29P332K
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7
(Homo sapiens (Human))
BDBM50436151
(CHEMBL2398212)
Show SMILES
Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
Show InChI
InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
420
n/a
n/a
n/a
n/a
n/a
n/a
Progenra, Inc.
Curated by
ChEMBL
Assay Description
Inhibition of full length wild-type human N-terminal His-tagged USP7 expressed in baculovirus infected Sf9 cells using Ub-AMC as substrate preincubat...
J Med Chem
61:
422
-
443
(2018)
Article DOI:
10.1021/acs.jmedchem.7b00498
BindingDB Entry DOI:
10.7270/Q2CR5WVG
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7
(Homo sapiens (Human))
BDBM50436151
(CHEMBL2398212)
Show SMILES
Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
Show InChI
InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
n/a
n/a
424
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
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