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Found 29 hits Enz. Inhib. hit(s) with Target = 'Urease' and Ligand = 'BDBM50229993'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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1.96E+4n/an/an/an/an/an/an/an/a



COMSATS Institute of Information Technology

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol method


Eur J Med Chem 46: 5473-9 (2011)


Article DOI: 10.1016/j.ejmech.2011.09.009
BindingDB Entry DOI: 10.7270/Q2GM87QH
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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US Patent
2.00E+4n/a 2.10E+4n/an/an/an/a6.8n/a



TBA

US Patent


Assay Description
Reaction mixtures consisting of 25 μL (1 unit/well) of Jack bean (Canavalia ensiformis) urease, 55 μL of buffer at pH 6.8, 100 mM of urea, ...


US Patent US9447057 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q2T
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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2.00E+4n/a 2.10E+4n/an/an/an/an/an/a



University of Karachi



Assay Description
Reaction mixture consisting of 25 µL of Jack bean (Canavalia ensiformis) urease (1 unit/well), 55 µL of 100 mM urea dissolved in phosphate buffer (4 ...


Bioorg Chem 64: 85-96 (2016)


Article DOI: 10.1016/j.bioorg.2015.12.007
BindingDB Entry DOI: 10.7270/Q2GX49CF
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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2.00E+4n/an/an/an/an/an/an/an/a



University Karachi

Curated by ChEMBL


Assay Description
Competitive inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by Lineweaver-Burk/Dixon plot analysi...


Eur J Med Chem 74: 314-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.01.001
BindingDB Entry DOI: 10.7270/Q2VH5QBM
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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2.30E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Canavalia ensiformis (jack bean) urease assessed as release of ammonia after 30 min by indophenol method


Citation and Details

Article DOI: 10.1007/s00044-012-0376-4
BindingDB Entry DOI: 10.7270/Q2P84FT7
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 560n/an/an/an/an/an/a



Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr.

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease using urea as substrate pretreated for 15 mins followed by substrate addition by phenol red based spectrophotometric m...


Bioorg Med Chem Lett 27: 3014-3018 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.019
BindingDB Entry DOI: 10.7270/Q20004H0
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 1.95E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease using urea as substrate assessed as ammonia production incubated for 15 mins by indophenol method


Bioorg Med Chem 23: 7211-8 (2015)


Article DOI: 10.1016/j.bmc.2015.10.017
BindingDB Entry DOI: 10.7270/Q2W097RV
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 1.95E+4n/an/an/an/a6.830



Universiti Teknologi MARA (UiTM), Puncak Alam Campus



Assay Description
To understand the binding modes of the compounds given in Table 1, all ligands were docked into the binding site of Urease enzyme. The top ranked con...


Bioorg Chem 66: 80-7 (2016)


Article DOI: 10.1016/j.bioorg.2016.03.010
BindingDB Entry DOI: 10.7270/Q20G3HXW
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.08E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate incubated for 15 mins by indophenol method


Citation and Details

Article DOI: 10.1016/j.bmc.2019.115123
BindingDB Entry DOI: 10.7270/Q2R49VCH
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.09E+4n/an/an/an/a8.2n/a



Quaid-i-Azam University



Assay Description
The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...


Chem Biol Drug Des 87: 434-43 (2016)


Article DOI: 10.1111/cbdd.12675
BindingDB Entry DOI: 10.7270/Q2CZ35X0
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a



The Islamia University of Bahawalpur

Curated by ChEMBL


Assay Description
Inhibition of jack bean Urease assessed as ammonia production after 15 mins by indophenol method


Bioorg Med Chem 23: 6049-58 (2015)


Article DOI: 10.1016/j.bmc.2015.05.038
BindingDB Entry DOI: 10.7270/Q2V40WZ2
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Universiti Teknologi MARA Puncak Alam Campus

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by Weatherburn assay


Bioorg Med Chem Lett 25: 3285-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.069
BindingDB Entry DOI: 10.7270/Q2GT5PZZ
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/a6.830



Solapur University



Assay Description
Mixture of 25 μL of urease enzyme (Jack bean) solution containing 1 unit of enzyme (1 unit = 0.02 mg of enzyme) was dissolved in phosphate buffe...


J Enzyme Inhib Med Chem 28: 1316-23 (2013)


Article DOI: 10.3109/14756366.2012.740477
BindingDB Entry DOI: 10.7270/Q2J965BH
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Khyber Medical College



Assay Description
Reaction mixtures comprising 25 μL of enzyme (jack bean urease) solution and 55 μL of buffers containing 100 mM urea were incubated with 5 ...


J Enzyme Inhib Med Chem 26: 480-4 (2011)


Article DOI: 10.3109/14756366.2010.528415
BindingDB Entry DOI: 10.7270/Q2CZ3626
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Quaid-i-Azam University



Assay Description
The synthesized compounds (4a-e, 5a-e) were tested for their in vitro urease inhibition activities at 0.2 mM concentration against jack bean urease. ...


J Enzyme Inhib Med Chem 25: 572-6 (2010)


Article DOI: 10.3109/14756360903389864
BindingDB Entry DOI: 10.7270/Q25H7F5M
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Bahauddin Zakariya University



Assay Description
Inhibition assay using urease from jack bean.


J Enzyme Inhib Med Chem 24: 437-46 (2009)


Article DOI: 10.1080/14756360802188420
BindingDB Entry DOI: 10.7270/Q2HH6HPW
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Canavalia ensiformis (jack bean) urease using urea as substrate after 15 min by indophenol-based spectrophotometric analysis


Citation and Details

Article DOI: 10.1007/s00044-011-9804-0
BindingDB Entry DOI: 10.7270/Q24B346S
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Canavalia ensiformis (jack bean) urease assessed as inhibition of ammonia production after 15 min by indophenol method


Citation and Details

Article DOI: 10.1007/s00044-013-0575-7
BindingDB Entry DOI: 10.7270/Q23N268X
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a



University Karachi

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by indophenol method


Eur J Med Chem 74: 314-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.01.001
BindingDB Entry DOI: 10.7270/Q2VH5QBM
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/an/an/a



COMSATS Institute of Information Technology

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol method


Eur J Med Chem 46: 5473-9 (2011)


Article DOI: 10.1016/j.ejmech.2011.09.009
BindingDB Entry DOI: 10.7270/Q2GM87QH
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.10E+4n/an/an/an/a6.830



University of Peshawar



Assay Description
Reaction mixtures comprising 25 μL of enzyme (jack bean urease) solution and 55 μL of buffer containing 100 mM urea were incubated with 5 &...


J Enzyme Inhib Med Chem 25: 296-9 (2010)


Article DOI: 10.3109/14756360903179385
BindingDB Entry DOI: 10.7270/Q2TB15TQ
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.11E+4n/an/an/an/an/an/a



Quaid-i-Azam University



Assay Description
In vitro inhibition assay using jack bean urease.


J Enzyme Inhib Med Chem 24: 151-6 (2009)


Article DOI: 10.1080/14756360801945598
BindingDB Entry DOI: 10.7270/Q29022CX
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.13E+4n/an/an/an/an/an/a



University of the Punjab

Curated by ChEMBL


Assay Description
Inhibition of jack beans urease assessed as hydrolysis of urea into ammonia preincubated for 10 mins followed by urea addition measured after 10 mins...


Eur J Med Chem 102: 464-70 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.011
BindingDB Entry DOI: 10.7270/Q2PV6N68
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.13E+4n/an/an/an/an/an/a



Imam Abdulrahman Bin Faisal University

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate after 15 mins by indophenol method


Bioorg Med Chem 26: 152-160 (2018)


Article DOI: 10.1016/j.bmc.2017.11.028
BindingDB Entry DOI: 10.7270/Q22N54VJ
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.15E+4n/an/an/an/an/an/a



University of Mysore

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease assessed as reduction in ammonia production incubated at 30 degC for 15 mins by indophenol method


Eur J Med Chem 87: 657-61 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.098
BindingDB Entry DOI: 10.7270/Q21N82QR
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.23E+4n/an/an/an/an/an/a



Quaid-i-Azam University

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol method


Eur J Med Chem 70: 487-96 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.012
BindingDB Entry DOI: 10.7270/Q2W097DC
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 2.23E+4n/an/an/an/an/an/a



Quaid-i-Azam University

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease using urea as substrate assessed as reduction in ammonia production after 30 mins by indophenol method


Bioorg Med Chem 24: 4452-4463 (2016)


Article DOI: 10.1016/j.bmc.2016.07.042
BindingDB Entry DOI: 10.7270/Q2VX0JF4
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 6.83E+5n/an/an/an/an/an/a



Karadeniz Technical University

Curated by ChEMBL


Assay Description
Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins


Eur J Med Chem 69: 622-31 (2013)


Article DOI: 10.1016/j.ejmech.2013.07.040
BindingDB Entry DOI: 10.7270/Q20V8GRX
More data for this
Ligand-Target Pair
Urease


(Canavalia ensiformis (Jack bean) (Horse bean))
BDBM50229993
PNG
(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Show SMILES NC(N)=S
Show InChI InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
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n/an/a 6.83E+5n/an/an/an/an/an/a



Karadeniz Technical University

Curated by ChEMBL


Assay Description
Inhibition of Jack bean urease using urea as substrate assessed as production of ammonia after 15 mins


Eur J Med Chem 67: 230-42 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.045
BindingDB Entry DOI: 10.7270/Q25T3PD7
More data for this
Ligand-Target Pair