BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM24461'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM24461 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	999	-33.9	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
Amgen					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM24461 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 by HTRF assay				J Med Chem 55: 1868-97 (2012) Article DOI: 10.1021/jm201331s BindingDB Entry DOI: 10.7270/Q23B616C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair