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Found 1 hit Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM50210699'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210699
PNG
(CHEMBL3896615)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34ClN7O3/c1-37-12-14-38(15-13-37)11-4-16-41-28-19-26-25(18-27(28)40-2)29(33-20-32-26)34-22-7-9-23(10-8-22)35-30(39)36-24-6-3-5-21(31)17-24/h3,5-10,17-20H,4,11-16H2,1-2H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 588n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair