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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)' and Ligand = 'BDBM17708'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM17708
PNG
(2-aminobenzoxazole, 33 | N-{4-chloro-3-[(4-methylp...)
Show SMILES CNc1cc(Oc2ccc3oc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)ncn1
Show InChI InChI=1S/C24H26ClN7O2/c1-26-22-13-23(28-15-27-22)33-18-4-6-21-20(12-18)30-24(34-21)29-17-3-5-19(25)16(11-17)14-32-9-7-31(2)8-10-32/h3-6,11-13,15H,7-10,14H2,1-2H3,(H,29,30)(H,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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Patents

Article
PubMed
20n/an/an/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 50: 4351-4373 (2007)


Article DOI: 10.1021/jm070034i
BindingDB Entry DOI: 10.7270/Q21V5C74
More data for this
Ligand-Target Pair