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Found 1 hit Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)' and Ligand = 'BDBM17709'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM17709
PNG
(2-aminobenzoxazole, 34 | N-(4-chloro-3-{[(2S)-1-me...)
Show SMILES CN1CCC[C@H]1COc1cc(Nc2nc3cc(Oc4ccnc5[nH]ccc45)ccc3o2)ccc1Cl |r|
Show InChI InChI=1S/C26H24ClN5O3/c1-32-12-2-3-17(32)15-33-24-13-16(4-6-20(24)27)30-26-31-21-14-18(5-7-23(21)35-26)34-22-9-11-29-25-19(22)8-10-28-25/h4-11,13-14,17H,2-3,12,15H2,1H3,(H,28,29)(H,30,31)/t17-/m0/s1
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MMDB

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Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 50: 4351-4373 (2007)


Article DOI: 10.1021/jm070034i
More data for this
Ligand-Target Pair