Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM187159'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187159 (US9670181, 39 1-ethyl-6,7-dimethoxy-4-((6-methoxy-...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H27N3O4/c1-6-20-18-13-23(32-5)22(31-4)12-17(18)19(25(29)28-20)11-15-9-14-10-16(30-3)7-8-21(14)27-24(15)26-2/h7-10,12-13H,6,11H2,1-5H3,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
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