Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM194425'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194425 (US9200016, 107 | US9902710, Compound 107) Show SMILES CCn1c2cc(Cc3cncc4cc(OC)c(OC)cc34)ccc2oc1=O Show InChI InChI=1S/C21H20N2O4/c1-4-23-17-8-13(5-6-18(17)27-21(23)24)7-14-11-22-12-15-9-19(25-2)20(26-3)10-16(14)15/h5-6,8-12H,4,7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194425 (US9200016, 107 | US9902710, Compound 107) Show SMILES CCn1c2cc(Cc3cncc4cc(OC)c(OC)cc34)ccc2oc1=O Show InChI InChI=1S/C21H20N2O4/c1-4-23-17-8-13(5-6-18(17)27-21(23)24)7-14-11-22-12-15-9-19(25-2)20(26-3)10-16(14)15/h5-6,8-12H,4,7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	7.4	37
Allergan, Inc.; Exonhit Therapeutics, SA US Patent					Assay Description The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....				US Patent US9200016 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81PH
					More data for this Ligand-Target Pair