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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50180269'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50180269
PNG
(CHEMBL3814367)
Show SMILES Cn1c(OCCOc2cn(CC3CC3)nc(-c3ccnn3-c3ccccc3)c2=O)nc2ccccc12
Show InChI InChI=1S/C27H26N6O3/c1-31-22-10-6-5-9-21(22)29-27(31)36-16-15-35-24-18-32(17-19-11-12-19)30-25(26(24)34)23-13-14-28-33(23)20-7-3-2-4-8-20/h2-10,13-14,18-19H,11-12,15-17H2,1H3
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n/an/a 4.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of human full length PDE10A2 expressed in African green monkey COS7 cells using [3H]cGMP as substrate preincubated for 30 mins followed by...

Bioorg Med Chem 24: 3447-55 (2016)


Article DOI: 10.1016/j.bmc.2016.05.049
BindingDB Entry DOI: 10.7270/Q2H9974G
More data for this
Ligand-Target Pair