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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50209518'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209518
PNG
(3-[2-(2'-ethyl-biphenyl-4-yl)-quinolin-4-ylamino]-...)
Show SMILES CCc1ccccc1-c1ccc(cc1)-c1cc(NCCC(O)=O)c2ccccc2n1
Show InChI InChI=1S/C26H24N2O2/c1-2-18-7-3-4-8-21(18)19-11-13-20(14-12-19)24-17-25(27-16-15-26(29)30)22-9-5-6-10-23(22)28-24/h3-14,17H,2,15-16H2,1H3,(H,27,28)(H,29,30)
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PC cid
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Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair