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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50209532'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50209532
PNG
(2-{[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-q...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(N(C)C(C)C(O)=O)c1C#N |w:27.30|
Show InChI InChI=1S/C28H24FN3O3/c1-4-35-25-8-6-5-7-21(25)18-9-11-19(12-10-18)26-23(16-30)27(32(3)17(2)28(33)34)22-15-20(29)13-14-24(22)31-26/h5-15,17H,4H2,1-3H3,(H,33,34)
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Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 17: 2869-73 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.061
BindingDB Entry DOI: 10.7270/Q2NS0TK0
More data for this
Ligand-Target Pair