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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50242390'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50242390
PNG
(CHEMBL4069039)
Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C21H23N7O/c1-15-25-19-20(27-7-9-29-10-8-27)22-14-23-21(19)28(15)12-16-3-5-17(6-4-16)18-11-24-26(2)13-18/h3-6,11,13-14H,7-10,12H2,1-2H3
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n/an/a 68n/an/an/an/an/an/a



Nanchang University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...

Bioorg Med Chem 25: 3315-3329 (2017)


Article DOI: 10.1016/j.bmc.2017.04.019
BindingDB Entry DOI: 10.7270/Q25X2CB8
More data for this
Ligand-Target Pair