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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50319195'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50319195
PNG
(8-Methoxy-4-(methoxycarbonyl-methyl-amino)-3-methy...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(C)C(=O)OC
Show InChI InChI=1S/C17H21N5O3/c1-6-7-12-18-10(2)14-16(21(3)17(23)25-5)19-11-8-9-13(24-4)20-15(11)22(12)14/h8-9H,6-7H2,1-5H3
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MMDB

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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...

J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N
More data for this
Ligand-Target Pair