Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50357828'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50357828 (CHEMBL1915912) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4sc(C)nc4C)n3c2n1 Show InChI InChI=1S/C17H17N5OS/c1-8-14-9(2)20-17(15-10(3)18-11(4)24-15)22(14)16-12(19-8)6-7-13(21-16)23-5/h6-7H,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
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