Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A' and Ligand = 'BDBM14385'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM14385 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1,1-dimet...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)COc2cccs2)cc1OC1CCCC1 Show InChI InChI=1S/C26H31N5O3S/c1-26(2,15-33-21-9-6-12-35-21)25-29-22-23(27)28-16-31(24(22)30-25)14-17-10-11-19(32-3)20(13-17)34-18-7-4-5-8-18/h6,9-13,16,18H,4-5,7-8,14-15,27H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	236	-37.4	n/a	n/a	n/a	n/a	n/a	8.0	22
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
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