Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM50017318'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50017318 (CHEMBL3288004) Show SMILES Oc1ccc(c(CN2CCOCC2)c1)-c1cccc(Oc2ncc(F)cc2C(=O)N[C@@H]2CC[C@@H](CC2)NC(=O)c2cncc(O)c2)c1 |r,wU:33.39,30.32,(16.71,-34.22,;15.38,-33.46,;14.04,-34.24,;12.71,-33.47,;12.7,-31.93,;14.02,-31.15,;14.01,-29.61,;15.34,-28.83,;16.68,-29.6,;18,-28.83,;18,-27.29,;16.66,-26.52,;15.33,-27.3,;15.36,-31.91,;11.37,-31.17,;10.03,-31.95,;8.69,-31.18,;8.69,-29.64,;10.02,-28.87,;10.02,-27.33,;8.69,-26.56,;7.35,-27.33,;6.01,-26.56,;6.01,-25.01,;4.67,-24.24,;7.34,-24.24,;8.68,-25,;10.01,-24.23,;10.01,-22.69,;11.35,-24.99,;12.68,-24.22,;14.02,-24.99,;15.35,-24.23,;15.35,-22.68,;14.02,-21.91,;12.68,-22.69,;16.7,-21.91,;18.03,-22.68,;18.03,-24.23,;19.36,-21.92,;19.35,-20.39,;20.68,-19.62,;22.02,-20.39,;22.01,-21.93,;23.34,-22.7,;20.68,-22.69,;11.36,-29.63,)| Show InChI InChI=1S/C35H36FN5O6/c36-25-17-32(34(45)40-27-6-4-26(5-7-27)39-33(44)23-14-29(43)20-37-18-23)35(38-19-25)47-30-3-1-2-22(16-30)31-9-8-28(42)15-24(31)21-41-10-12-46-13-11-41/h1-3,8-9,14-20,26-27,42-43H,4-7,10-13,21H2,(H,39,44)(H,40,45)/t26-,27+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysis				J Med Chem 57: 4661-76 (2014) Article DOI: 10.1021/jm5001216 BindingDB Entry DOI: 10.7270/Q2708302
					More data for this Ligand-Target Pair