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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM50314565'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50314565
PNG
(1-(4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indoli...)
Show SMILES CC(=O)N1CCN(CCCNc2nnc(-c3cccc(F)c3)c3c2cc2ccccn32)CC1
Show InChI InChI=1S/C25H27FN6O/c1-18(33)31-14-12-30(13-15-31)10-5-9-27-25-22-17-21-8-2-3-11-32(21)24(22)23(28-29-25)19-6-4-7-20(26)16-19/h2-4,6-8,11,16-17H,5,9-10,12-15H2,1H3,(H,27,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.90E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 2163-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.044
BindingDB Entry DOI: 10.7270/Q2NK3F54
More data for this
Ligand-Target Pair