Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM119686'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM119686 (US8680116, 1-63) Show SMILES COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(c3)-c3ccccn3)c2cc1OC Show InChI InChI=1S/C26H20N2O3S/c1-30-21-14-18-20(15-22(21)31-2)28-26(29)25(23-10-6-12-32-23)24(18)17-8-5-7-16(13-17)19-9-3-4-11-27-19/h3-15H,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...				US Patent US8680116 (2014) BindingDB Entry DOI: 10.7270/Q2N29VM1
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