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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-inhibited 3',5'-cyclic phosphodiesterase B' and Ligand = 'BDBM14744'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (Human))
BDBM14744
PNG
((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C#N)c2cc1OC |r|
Show InChI InChI=1S/C21H20N4O3/c1-26-19-9-16-17(10-20(19)27-2)23-13-24-21(16)25-8-7-15(12-25)28-18-6-4-3-5-14(18)11-22/h3-6,9-10,13,15H,7-8,12H2,1-2H3/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
<100n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair