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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-specific 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM14402'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14402
PNG
(5-(5-Acetyl-2-propoxy-3-pyridinyl)-3-ethyl-2-(1-is...)
Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(C1)C(C)C)C(C)=O
Show InChI InChI=1S/C23H30N6O3/c1-6-8-32-23-17(9-15(10-24-23)14(5)30)21-25-19-18(7-2)29(27-20(19)22(31)26-21)16-11-28(12-16)13(3)4/h9-10,13,16H,6-8,11-12H2,1-5H3,(H,25,26,31)
PDB
MMDB

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Article
PubMed
n/an/a 5.20n/an/an/an/an/an/a



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair