Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-specific 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM14408'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14408 (5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-[(1-me...) Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(Cc3nccn3C)nc2c(=O)[nH]1)C(C)=O Show InChI InChI=1S/C23H27N7O3/c1-5-7-10-33-23-16(11-15(12-25-23)14(3)31)21-26-19-17(6-2)30(28-20(19)22(32)27-21)13-18-24-8-9-29(18)4/h8-9,11-12H,5-7,10,13H2,1-4H3,(H,26,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
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