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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cystic fibrosis transmembrane conductance regulator protein (CFTR)' and Ligand = 'BDBM221935'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cystic fibrosis transmembrane conductance regulator protein (CFTR)


(Cricetulus griseus (Chinese hamster))
BDBM221935
PNG
(US9303035, 1.3)
Show SMILES Cc1ccc(o1)[C@H]1NCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1 |r|
Show InChI InChI=1/C22H22N4O3/c1-13-9-10-15(29-13)17-20-19-16(21(27)25(3)22(28)24(19)2)18(26(20)12-11-23-17)14-7-5-4-6-8-14/h4-10,17,23H,11-12H2,1-3H3/t17-/s2
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...


US Patent US9303035 (2016)

More data for this
Ligand-Target Pair