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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cystic fibrosis transmembrane conductance regulator protein (CFTR)' and Ligand = 'BDBM221949'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cystic fibrosis transmembrane conductance regulator protein (CFTR)


(Cricetulus griseus (Chinese hamster))
BDBM221949
PNG
(US9303035, 1.17)
Show SMILES Cn1c2c3C(NCCn3c(-c3ccccc3)c2c(=O)n(C)c1=O)C1CCC=CC1 |c:30|
Show InChI InChI=1/C23H26N4O2/c1-25-20-17(22(28)26(2)23(25)29)19(16-11-7-4-8-12-16)27-14-13-24-18(21(20)27)15-9-5-3-6-10-15/h3-5,7-8,11-12,15,18,24H,6,9-10,13-14H2,1-2H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18.1n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...


US Patent US9303035 (2016)

More data for this
Ligand-Target Pair