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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cystic fibrosis transmembrane conductance regulator protein (CFTR)' and Ligand = 'BDBM221984'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cystic fibrosis transmembrane conductance regulator protein (CFTR)


(Cricetulus griseus (Chinese hamster))
BDBM221984
PNG
(US9303035, 7.0a)
Show SMILES Cc1csc(n1)-c1n2CC(CO)OC(c3ccc(Cl)o3)c2c2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1/C20H19ClN4O5S/c1-9-8-31-18(22-9)15-13-14(23(2)20(28)24(3)19(13)27)16-17(11-4-5-12(21)30-11)29-10(7-26)6-25(15)16/h4-5,8,10,17,26H,6-7H2,1-3H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...


US Patent US9303035 (2016)

More data for this
Ligand-Target Pair