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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cystic fibrosis transmembrane conductance regulator protein (CFTR)' and Ligand = 'BDBM221985'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cystic fibrosis transmembrane conductance regulator protein (CFTR)


(Cricetulus griseus (Chinese hamster))
BDBM221985
PNG
(US9303035, 7.1a)
Show SMILES Cn1c2c3[C@H](O[C@H](CO)Cn3c(-c3nc(CO)cs3)c2c(=O)n(C)c1=O)c1ccc(Cl)o1
Show InChI InChI=1S/C20H19ClN4O6S/c1-23-14-13(19(28)24(2)20(23)29)15(18-22-9(6-26)8-32-18)25-5-10(7-27)30-17(16(14)25)11-3-4-12(21)31-11/h3-4,8,10,17,26-27H,5-7H2,1-2H3/t10-,17+/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.610n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...


US Patent US9303035 (2016)

More data for this
Ligand-Target Pair