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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'p110alpha-iSH2 p85alpha Complex' and Ligand = 'BDBM207476'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207476
PNG
(US9260439, 360)
Show SMILES C[C@@]1(CCN(C1)C(=O)N1CCC1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O2/c1-23(4-8-31(15-23)22(33)30-5-2-6-30)32-7-3-17-18(16-13-25-20(24)26-14-16)27-21(28-19(17)32)29-9-11-34-12-10-29/h13-14H,2-12,15H2,1H3,(H2,24,25,26)/t23-/m0/s1
PDB

UniProtKB/SwissProt

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US Patent
<0.0180n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair