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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'p53-MDM2' and Ligand = 'BDBM236267'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p53-MDM2


(Homo sapiens (Human))
BDBM236267
PNG
(US9365576, 20)
Show SMILES COc1ccc(cc1-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)N(C)C |r|
Show InChI InChI=1/C32H31Cl2N3O3/c1-18(2)36-27(24-15-21(31(38)35(4)5)10-14-28(24)40-6)17-25-30(36)29(20-8-12-22(33)13-9-20)37(32(25)39)26-16-23(34)11-7-19(26)3/h7-18,29H,1-6H3/t29-/s2
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0750n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...


US Patent US9365576 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43XR
More data for this
Ligand-Target Pair