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Compile Data Set for Download or QSAR

Found 134 hits with Last Name = 'allcock' and Initial = 'rw'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393511
PNG
(CHEMBL2158056)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1nc(-c2cccc(c2)-[#7+](-[#8-])=O)c2ncccc2c1=O
Show InChI InChI=1S/C18H16N4O3/c1-12(2)8-10-21-18(23)15-7-4-9-19-17(15)16(20-21)13-5-3-6-14(11-13)22(24)25/h3-9,11H,10H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363909
PNG
(CHEMBL1946933)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2sc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H12F3N3O2S/c1-6-5-9(21)19-20-10(6)7-3-4-8(22-2)11-12(7)23-13(18-11)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,19,21)
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n/an/a 21n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393510
PNG
(CHEMBL1232082)
Show SMILES [O-][N+](=O)c1cccc(c1)-n1c2ncccc2c(=O)n(Cc2ccncc2)c1=O
Show InChI InChI=1S/C19H13N5O4/c25-18-16-5-2-8-21-17(16)23(14-3-1-4-15(11-14)24(27)28)19(26)22(18)12-13-6-9-20-10-7-13/h1-11H,12H2
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n/an/a 22n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50085135
PNG
(4-(8-(3-nitrophenyl)-1,7-naphthyridin-6-yl)benzoic...)
Show SMILES OC(=O)c1ccc(cc1)-c1cc2cccnc2c(n1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H13N3O4/c25-21(26)14-8-6-13(7-9-14)18-12-16-4-2-10-22-19(16)20(23-18)15-3-1-5-17(11-15)24(27)28/h1-12H,(H,25,26)
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n/an/a 29n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344327
PNG
(2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]py...)
Show SMILES COc1ccc(-c2ccc(=O)n(Cc3ccccc3)n2)c2cc(nn12)C(C)C
Show InChI InChI=1S/C22H22N4O2/c1-15(2)19-13-20-17(9-12-22(28-3)26(20)24-19)18-10-11-21(27)25(23-18)14-16-7-5-4-6-8-16/h4-13,15H,14H2,1-3H3
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n/an/a 55n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344329
PNG
(2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]py...)
Show SMILES COc1ccc(C2=NN(Cc3ccccc3)C(=O)CC2)c2cc(nn12)C(C)C |t:6|
Show InChI InChI=1S/C22H24N4O2/c1-15(2)19-13-20-17(9-12-22(28-3)26(20)24-19)18-10-11-21(27)25(23-18)14-16-7-5-4-6-8-16/h4-9,12-13,15H,10-11,14H2,1-3H3
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n/an/a 120n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50363909
PNG
(CHEMBL1946933)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2sc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H12F3N3O2S/c1-6-5-9(21)19-20-10(6)7-3-4-8(22-2)11-12(7)23-13(18-11)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,19,21)
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Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363906
PNG
(CHEMBL1946747)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)n2cc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H13F3N4O2/c1-7-5-11(22)19-20-12(7)8-3-4-9(23-2)13-18-10(6-21(8)13)14(15,16)17/h3-4,6-7H,5H2,1-2H3,(H,19,22)
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n/an/a 260n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363910
PNG
(CHEMBL1946934)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2cc(sc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C15H13F3N2O2S/c1-7-5-12(21)19-20-13(7)8-3-4-10(22-2)14-9(8)6-11(23-14)15(16,17)18/h3-4,6-7H,5H2,1-2H3,(H,19,21)
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n/an/a 280n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50108504
PNG
(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Show SMILES OC(=O)c1ccc(cc1)-c1cc2cccnc2c(n1)-c1ccc2nonc2c1
Show InChI InChI=1S/C21H12N4O3/c26-21(27)13-5-3-12(4-6-13)17-10-14-2-1-9-22-19(14)20(23-17)15-7-8-16-18(11-15)25-28-24-16/h1-11H,(H,26,27)
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University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363912
PNG
(CHEMBL1946936)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2[nH]c(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H13F3N4O2/c1-6-5-9(22)20-21-10(6)7-3-4-8(23-2)12-11(7)18-13(19-12)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,18,19)(H,20,22)
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Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393509
PNG
(PYRIDOPYRIDAZINONE)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12
Show InChI InChI=1S/C19H13N5O3/c25-19-16-5-2-8-21-18(16)17(14-3-1-4-15(11-14)24(26)27)22-23(19)12-13-6-9-20-10-7-13/h1-11H,12H2
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University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393512
PNG
(CHEMBL2158057)
Show SMILES Clc1cccc(c1)-c1nn(CC2CC2)c(=O)c2cccnc12
Show InChI InChI=1S/C17H14ClN3O/c18-13-4-1-3-12(9-13)15-16-14(5-2-8-19-16)17(22)21(20-15)10-11-6-7-11/h1-5,8-9,11H,6-7,10H2
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University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363911
PNG
(CHEMBL1946935)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2ccc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C16H14F3N3O2/c1-8-7-13(23)21-22-14(8)9-3-5-11(24-2)15-10(9)4-6-12(20-15)16(17,18)19/h3-6,8H,7H2,1-2H3,(H,21,23)
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n/an/a 350n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363913
PNG
(CHEMBL1946937)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2cc(oc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C15H13F3N2O3/c1-7-5-12(21)19-20-13(7)8-3-4-10(22-2)14-9(8)6-11(23-14)15(16,17)18/h3-4,6-7H,5H2,1-2H3,(H,19,21)
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Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363905
PNG
(CHEMBL1946746)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2nc(nn12)C(F)(F)F |t:6|
Show InChI InChI=1S/C13H12F3N5O2/c1-6-5-8(22)18-19-10(6)7-3-4-9(23-2)21-11(7)17-12(20-21)13(14,15)16/h3-4,6H,5H2,1-2H3,(H,18,22)
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n/an/a 430n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393518
PNG
(CHEMBL2158064)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CN(Cc2ccccc2)C(=O)C1 |r|
Show InChI InChI=1S/C23H27NO3/c1-26-21-12-11-18(13-22(21)27-20-9-5-6-10-20)19-14-23(25)24(16-19)15-17-7-3-2-4-8-17/h2-4,7-8,11-13,19-20H,5-6,9-10,14-16H2,1H3/t19-/m1/s1
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n/an/a 730n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 830n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50363911
PNG
(CHEMBL1946935)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2ccc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C16H14F3N3O2/c1-8-7-13(23)21-22-14(8)9-3-5-11(24-2)15-10(9)4-6-12(20-15)16(17,18)19/h3-6,8H,7H2,1-2H3,(H,21,23)
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Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393515
PNG
(CHEMBL2158061)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C)C(=O)C1 |r|
Show InChI InChI=1S/C17H23NO3/c1-18-11-13(10-17(18)19)12-7-8-15(20-2)16(9-12)21-14-5-3-4-6-14/h7-9,13-14H,3-6,10-11H2,1-2H3/t13-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363907
PNG
(CHEMBL1946748)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2oc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H12F3N3O3/c1-6-5-9(21)19-20-10(6)7-3-4-8(22-2)11-12(7)23-13(18-11)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,19,21)
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n/an/a 1.01E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50240404
PNG
((Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3...)
Show SMILES CC(C)C(=O)c1c(nn2ccccc12)C(C)C
Show InChI InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344325
PNG
(4-(6-chloropyridazin-3-yl)-2-isopropyl-7-methoxypy...)
Show SMILES COc1ccc(-c2ccc(Cl)nn2)c2cc(nn12)C(C)C
Show InChI InChI=1S/C15H15ClN4O/c1-9(2)12-8-13-10(11-5-6-14(16)18-17-11)4-7-15(21-3)20(13)19-12/h4-9H,1-3H3
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n/an/a 1.38E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50363906
PNG
(CHEMBL1946747)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)n2cc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H13F3N4O2/c1-7-5-11(22)19-20-12(7)8-3-4-9(23-2)13-18-10(6-21(8)13)14(15,16)17/h3-4,6-7H,5H2,1-2H3,(H,19,22)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363908
PNG
(CHEMBL1946932)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2nc(oc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H12F3N3O3/c1-6-5-9(21)19-20-10(6)7-3-4-8(22-2)12-11(7)18-13(23-12)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,19,21)
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n/an/a 1.52E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50040348
PNG
(8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...)
Show SMILES Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2[nH]1
Show InChI InChI=1S/C13H17N5O2/c14-12-15-9-10(16-12)17(5-7-1-2-7)13(20)18(11(9)19)6-8-3-4-8/h7-8H,1-6H2,(H3,14,15,16)
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344321
PNG
(2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]py...)
Show SMILES COc1cccc2c(c(nn12)C(C)C)C1=NN(Cc2ccccc2)C(=O)CC1 |t:16|
Show InChI InChI=1S/C22H24N4O2/c1-15(2)22-21(18-10-7-11-20(28-3)26(18)24-22)17-12-13-19(27)25(23-17)14-16-8-5-4-6-9-16/h4-11,15H,12-14H2,1-3H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344314
PNG
(CHEMBL1779432 | rac-2-Benzyl-4a-methyl-4,4a,5,6-te...)
Show SMILES CC12CCc3nn4ccccc4c3C1=NN(Cc1ccccc1)C(=O)C2 |c:16|
Show InChI InChI=1S/C21H20N4O/c1-21-11-10-16-19(17-9-5-6-12-24(17)22-16)20(21)23-25(18(26)13-21)14-15-7-3-2-4-8-15/h2-9,12H,10-11,13-14H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393516
PNG
(CHEMBL2158062)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CN(C)C(=O)C1 |r|
Show InChI InChI=1S/C17H23NO3/c1-18-11-13(10-17(18)19)12-7-8-15(20-2)16(9-12)21-14-5-3-4-6-14/h7-9,13-14H,3-6,10-11H2,1-2H3/t13-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344318
PNG
(CHEMBL1779436 | rac-9-Benzyl-1-isopropyl-6a,9,10b,...)
Show SMILES CC(C)c1nn2cccc3CC4CC(=O)N(Cc5ccccc5)N=C4c1c23 |c:24|
Show InChI InChI=1S/C22H22N4O/c1-14(2)20-19-21-17(11-16-9-6-10-25(23-20)22(16)19)12-18(27)26(24-21)13-15-7-4-3-5-8-15/h3-10,14,17H,11-13H2,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344326
PNG
(6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-y...)
Show SMILES COc1ccc(-c2ccc(=O)[nH]n2)c2cc(nn12)C(C)C
Show InChI InChI=1S/C15H16N4O2/c1-9(2)12-8-13-10(11-5-6-14(20)17-16-11)4-7-15(21-3)19(13)18-12/h4-9H,1-3H3,(H,17,20)
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n/an/a 2.58E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50344328
PNG
(6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-y...)
Show SMILES COc1ccc(C2=NNC(=O)CC2)c2cc(nn12)C(C)C |t:6|
Show InChI InChI=1S/C15H18N4O2/c1-9(2)12-8-13-10(11-5-6-14(20)17-16-11)4-7-15(21-3)19(13)18-12/h4,7-9H,5-6H2,1-3H3,(H,17,20)
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n/an/a 2.61E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50344326
PNG
(6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-y...)
Show SMILES COc1ccc(-c2ccc(=O)[nH]n2)c2cc(nn12)C(C)C
Show InChI InChI=1S/C15H16N4O2/c1-9(2)12-8-13-10(11-5-6-14(20)17-16-11)4-7-15(21-3)19(13)18-12/h4-9H,1-3H3,(H,17,20)
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n/an/a 2.75E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50363910
PNG
(CHEMBL1946934)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2cc(sc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C15H13F3N2O2S/c1-7-5-12(21)19-20-13(7)8-3-4-10(22-2)14-9(8)6-11(23-14)15(16,17)18/h3-4,6-7H,5H2,1-2H3,(H,19,21)
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n/an/a 2.85E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50344315
PNG
(5,6-Dihydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3...)
Show SMILES O=c1cc2CCc3nn4ccccc4c3-c2n[nH]1
Show InChI InChI=1S/C13H10N4O/c18-11-7-8-4-5-9-12(13(8)15-14-11)10-3-1-2-6-17(10)16-9/h1-3,6-7H,4-5H2,(H,14,18)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50363914
PNG
(CHEMBL1946938)
Show SMILES CCc1cc2c(ccc(OC)n2c1)C1=NNC(=O)CC1C |t:15|
Show InChI InChI=1S/C16H19N3O2/c1-4-11-8-13-12(5-6-15(21-3)19(13)9-11)16-10(2)7-14(20)17-18-16/h5-6,8-10H,4,7H2,1-3H3,(H,17,20)
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n/an/a 3.49E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50344306
PNG
((R)-6-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-m...)
Show SMILES CC(C)c1nn2ccccc2c1C1=NNC(=O)C[C@H]1C |r,t:14|
Show InChI InChI=1S/C15H18N4O/c1-9(2)14-13(11-6-4-5-7-19(11)18-14)15-10(3)8-12(20)16-17-15/h4-7,9-10H,8H2,1-3H3,(H,16,20)/t10-/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50042056
PNG
((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393517
PNG
(CHEMBL2158063)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(Cc2ccccc2)C(=O)C1 |r|
Show InChI InChI=1S/C23H27NO3/c1-26-21-12-11-18(13-22(21)27-20-9-5-6-10-20)19-14-23(25)24(16-19)15-17-7-3-2-4-8-17/h2-4,7-8,11-13,19-20H,5-6,9-10,14-16H2,1H3/t19-/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50010981
PNG
((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)
Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
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PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50240404
PNG
((Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3...)
Show SMILES CC(C)C(=O)c1c(nn2ccccc12)C(C)C
Show InChI InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393525
PNG
(CHEMBL2158070)
Show SMILES CCc1nc(cc2cccnc12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C17H14N2O2/c1-2-14-16-13(4-3-9-18-16)10-15(19-14)11-5-7-12(8-6-11)17(20)21/h3-10H,2H2,1H3,(H,20,21)
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50363907
PNG
(CHEMBL1946748)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2oc(nc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H12F3N3O3/c1-6-5-9(21)19-20-10(6)7-3-4-8(22-2)11-12(7)23-13(18-11)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,19,21)
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n/an/a 5.74E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393523
PNG
(CHEMBL2158068)
Show SMILES CCCOc1cc(ccc1OC)[C@@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C14H19NO3/c1-3-6-18-13-7-10(4-5-12(13)17-2)11-8-14(16)15-9-11/h4-5,7,11H,3,6,8-9H2,1-2H3,(H,15,16)/t11-/m0/s1
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n/an/a 6.20E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393522
PNG
(CHEMBL2158003)
Show SMILES CCOc1cc(ccc1OC)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C13H17NO3/c1-3-17-12-6-9(4-5-11(12)16-2)10-7-13(15)14-8-10/h4-6,10H,3,7-8H2,1-2H3,(H,14,15)/t10-/m1/s1
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50344327
PNG
(2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]py...)
Show SMILES COc1ccc(-c2ccc(=O)n(Cc3ccccc3)n2)c2cc(nn12)C(C)C
Show InChI InChI=1S/C22H22N4O2/c1-15(2)19-13-20-17(9-12-22(28-3)26(20)24-19)18-10-11-21(27)25(23-18)14-16-7-5-4-6-8-16/h4-13,15H,14H2,1-3H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE5A catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50363908
PNG
(CHEMBL1946932)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2nc(oc12)C(F)(F)F |t:6|
Show InChI InChI=1S/C14H12F3N3O3/c1-6-5-9(21)19-20-10(6)7-3-4-8(22-2)12-11(7)18-13(23-12)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,19,21)
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n/an/a 6.43E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393521
PNG
(CHEMBL2158067)
Show SMILES CCOc1cc(ccc1OC)[C@@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C13H17NO3/c1-3-17-12-6-9(4-5-11(12)16-2)10-7-13(15)14-8-10/h4-6,10H,3,7-8H2,1-2H3,(H,14,15)/t10-/m0/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50344311
PNG
(CHEMBL1779429 | rac-4,4a,5,6-Tetrahydro-2H-1,2,7,7...)
Show SMILES O=C1CC2CCc3nn4ccccc4c3C2=NN1 |c:18|
Show InChI InChI=1S/C13H12N4O/c18-11-7-8-4-5-9-12(13(8)15-14-11)10-3-1-2-6-17(10)16-9/h1-3,6,8H,4-5,7H2,(H,14,18)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Heriot-Watt University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate


Bioorg Med Chem Lett 21: 3307-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.021
BindingDB Entry DOI: 10.7270/Q2X067C3
More data for this
Ligand-Target Pair
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