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Compile Data Set for Download or QSAR

Found 114 hits with Last Name = 'asano' and Initial = 'd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130532
PNG
(CHEMBL3632692)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C23H25F3N2O3/c24-23(25,26)17-5-7-20(8-6-17)31-15-19(29)14-27-11-9-18(10-12-27)28-13-16-3-1-2-4-21(16)22(28)30/h1-8,18-19,29H,9-15H2
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n/an/a 100n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130533
PNG
(CHEMBL3632693)
Show SMILES COc1cc(ccc1OCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1/C24H27F3N2O4/c1-32-22-12-17(24(25,26)27)6-7-21(22)33-15-19(30)14-28-10-8-18(9-11-28)29-13-16-4-2-3-5-20(16)23(29)31/h2-7,12,18-19,30H,8-11,13-15H2,1H3
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n/an/a 330n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130525
PNG
(CHEMBL3632641)
Show SMILES OC(COc1ccc(cc1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-12-10-22(11-13-26)28(33)21-6-2-1-3-7-21)19-30-16-14-24(15-17-30)31-18-23-8-4-5-9-27(23)29(31)34/h1-13,24-25,32H,14-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130536
PNG
(CHEMBL3632696)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)NC(=O)c1ccccc1
Show InChI InChI=1/C22H25F3N2O3/c23-22(24,25)17-6-8-20(9-7-17)30-15-19(28)14-27-12-10-18(11-13-27)26-21(29)16-4-2-1-3-5-16/h1-9,18-19,28H,10-15H2,(H,26,29)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130533
PNG
(CHEMBL3632693)
Show SMILES COc1cc(ccc1OCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1/C24H27F3N2O4/c1-32-22-12-17(24(25,26)27)6-7-21(22)33-15-19(30)14-28-10-8-18(9-11-28)29-13-16-4-2-3-5-20(16)23(29)31/h2-7,12,18-19,30H,8-11,13-15H2,1H3
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n/an/a 480n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130532
PNG
(CHEMBL3632692)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C23H25F3N2O3/c24-23(25,26)17-5-7-20(8-6-17)31-15-19(29)14-27-11-9-18(10-12-27)28-13-16-3-1-2-4-21(16)22(28)30/h1-8,18-19,29H,9-15H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130525
PNG
(CHEMBL3632641)
Show SMILES OC(COc1ccc(cc1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-12-10-22(11-13-26)28(33)21-6-2-1-3-7-21)19-30-16-14-24(15-17-30)31-18-23-8-4-5-9-27(23)29(31)34/h1-13,24-25,32H,14-20H2
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n/an/a 590n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel alpha subunit Nav1.1


(Mus musculus)
BDBM50130535
PNG
(CHEMBL3632695)
Show SMILES OC(=O)\C=C\C(O)=O.COc1cc(ccc1COCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1/C25H29F3N2O4.C4H4O4/c1-33-23-12-19(25(26,27)28)7-6-18(23)15-34-16-21(31)14-29-10-8-20(9-11-29)30-13-17-4-2-3-5-22(17)24(30)32;5-3(6)1-2-4(7)8/h2-7,12,20-21,31H,8-11,13-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130525
PNG
(CHEMBL3632641)
Show SMILES OC(COc1ccc(cc1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-12-10-22(11-13-26)28(33)21-6-2-1-3-7-21)19-30-16-14-24(15-17-30)31-18-23-8-4-5-9-27(23)29(31)34/h1-13,24-25,32H,14-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel alpha subunit Nav1.1


(Mus musculus)
BDBM50130524
PNG
(CHEMBL3634332)
Show SMILES OC(COc1cccc(c1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-11-6-10-22(17-26)28(33)21-7-2-1-3-8-21)19-30-15-13-24(14-16-30)31-18-23-9-4-5-12-27(23)29(31)34/h1-12,17,24-25,32H,13-16,18-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130536
PNG
(CHEMBL3632696)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)NC(=O)c1ccccc1
Show InChI InChI=1/C22H25F3N2O3/c23-22(24,25)17-6-8-20(9-7-17)30-15-19(28)14-27-12-10-18(11-13-27)26-21(29)16-4-2-1-3-5-16/h1-9,18-19,28H,10-15H2,(H,26,29)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130512
PNG
(CHEMBL3634322)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)c1cccc2NC(=O)COc12
Show InChI InChI=1/C29H30N2O5/c32-22(18-35-26-12-5-4-9-24(26)28(34)21-7-2-1-3-8-21)17-31-15-13-20(14-16-31)23-10-6-11-25-29(23)36-19-27(33)30-25/h1-12,20,22,32H,13-19H2,(H,30,33)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130531
PNG
(CHEMBL3632691)
Show SMILES OC(COc1cccc(c1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C23H25F3N2O3/c24-23(25,26)17-5-3-6-20(12-17)31-15-19(29)14-27-10-8-18(9-11-27)28-13-16-4-1-2-7-21(16)22(28)30/h1-7,12,18-19,29H,8-11,13-15H2
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n/an/a 790n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130535
PNG
(CHEMBL3632695)
Show SMILES OC(=O)\C=C\C(O)=O.COc1cc(ccc1COCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1/C25H29F3N2O4.C4H4O4/c1-33-23-12-19(25(26,27)28)7-6-18(23)15-34-16-21(31)14-29-10-8-20(9-11-29)30-13-17-4-2-3-5-22(17)24(30)32;5-3(6)1-2-4(7)8/h2-7,12,20-21,31H,8-11,13-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
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n/an/a 790n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130537
PNG
(CHEMBL3632697)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1/C22H25F3N2O3/c23-22(24,25)17-6-8-20(9-7-17)30-15-19(28)14-27-12-10-16(11-13-27)21(29)26-18-4-2-1-3-5-18/h1-9,16,19,28H,10-15H2,(H,26,29)
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n/an/a 800n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130536
PNG
(CHEMBL3632696)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)NC(=O)c1ccccc1
Show InChI InChI=1/C22H25F3N2O3/c23-22(24,25)17-6-8-20(9-7-17)30-15-19(28)14-27-12-10-18(11-13-27)26-21(29)16-4-2-1-3-5-16/h1-9,18-19,28H,10-15H2,(H,26,29)
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n/an/a 800n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130524
PNG
(CHEMBL3634332)
Show SMILES OC(COc1cccc(c1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-11-6-10-22(17-26)28(33)21-7-2-1-3-8-21)19-30-15-13-24(14-16-30)31-18-23-9-4-5-12-27(23)29(31)34/h1-12,17,24-25,32H,13-16,18-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130528
PNG
(CHEMBL3634335)
Show SMILES COc1cccc(OCC(O)CN2CCC(CC2)N2Cc3ccccc3C2=O)c1
Show InChI InChI=1/C23H28N2O4/c1-28-20-6-4-7-21(13-20)29-16-19(26)15-24-11-9-18(10-12-24)25-14-17-5-2-3-8-22(17)23(25)27/h2-8,13,18-19,26H,9-12,14-16H2,1H3
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n/an/a 910n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130533
PNG
(CHEMBL3632693)
Show SMILES COc1cc(ccc1OCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1/C24H27F3N2O4/c1-32-22-12-17(24(25,26)27)6-7-21(22)33-15-19(30)14-28-10-8-18(9-11-28)29-13-16-4-2-3-5-20(16)23(29)31/h2-7,12,18-19,30H,8-11,13-15H2,1H3
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n/an/a 910n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130524
PNG
(CHEMBL3634332)
Show SMILES OC(COc1cccc(c1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-11-6-10-22(17-26)28(33)21-7-2-1-3-8-21)19-30-15-13-24(14-16-30)31-18-23-9-4-5-12-27(23)29(31)34/h1-12,17,24-25,32H,13-16,18-20H2
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n/an/a 920n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130522
PNG
(CHEMBL3634330)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)NC(=O)c1ccccc1
Show InChI InChI=1/C28H30N2O4/c31-24(19-30-17-15-23(16-18-30)29-28(33)22-11-5-2-6-12-22)20-34-26-14-8-7-13-25(26)27(32)21-9-3-1-4-10-21/h1-14,23-24,31H,15-20H2,(H,29,33)
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n/an/a 920n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130524
PNG
(CHEMBL3634332)
Show SMILES OC(COc1cccc(c1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-11-6-10-22(17-26)28(33)21-7-2-1-3-8-21)19-30-15-13-24(14-16-30)31-18-23-9-4-5-12-27(23)29(31)34/h1-12,17,24-25,32H,13-16,18-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130523
PNG
(CHEMBL3634331)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1/C28H30N2O4/c31-24(19-30-17-15-22(16-18-30)28(33)29-23-11-5-2-6-12-23)20-34-26-14-8-7-13-25(26)27(32)21-9-3-1-4-10-21/h1-14,22,24,31H,15-20H2,(H,29,33)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130537
PNG
(CHEMBL3632697)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1/C22H25F3N2O3/c23-22(24,25)17-6-8-20(9-7-17)30-15-19(28)14-27-12-10-16(11-13-27)21(29)26-18-4-2-1-3-5-18/h1-9,16,19,28H,10-15H2,(H,26,29)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130531
PNG
(CHEMBL3632691)
Show SMILES OC(COc1cccc(c1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C23H25F3N2O3/c24-23(25,26)17-5-3-6-20(12-17)31-15-19(29)14-27-10-8-18(9-11-27)28-13-16-4-1-2-7-21(16)22(28)30/h1-7,12,18-19,29H,8-11,13-15H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130534
PNG
(CHEMBL3632694)
Show SMILES OC(COCc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C24H27F3N2O3/c25-24(26,27)19-7-5-17(6-8-19)15-32-16-21(30)14-28-11-9-20(10-12-28)29-13-18-3-1-2-4-22(18)23(29)31/h1-8,20-21,30H,9-16H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50130536
PNG
(CHEMBL3632696)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)NC(=O)c1ccccc1
Show InChI InChI=1/C22H25F3N2O3/c23-22(24,25)17-6-8-20(9-7-17)30-15-19(28)14-27-12-10-18(11-13-27)26-21(29)16-4-2-1-3-5-16/h1-9,18-19,28H,10-15H2,(H,26,29)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.5 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130518
PNG
(CHEMBL3634326)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)N1C(=O)COc2ccccc12
Show InChI InChI=1/C29H30N2O5/c32-23(19-35-26-12-6-4-10-24(26)29(34)21-8-2-1-3-9-21)18-30-16-14-22(15-17-30)31-25-11-5-7-13-27(25)36-20-28(31)33/h1-13,22-23,32H,14-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130522
PNG
(CHEMBL3634330)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)NC(=O)c1ccccc1
Show InChI InChI=1/C28H30N2O4/c31-24(19-30-17-15-23(16-18-30)29-28(33)22-11-5-2-6-12-22)20-34-26-14-8-7-13-25(26)27(32)21-9-3-1-4-10-21/h1-14,23-24,31H,15-20H2,(H,29,33)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130523
PNG
(CHEMBL3634331)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1/C28H30N2O4/c31-24(19-30-17-15-22(16-18-30)28(33)29-23-11-5-2-6-12-23)20-34-26-14-8-7-13-25(26)27(32)21-9-3-1-4-10-21/h1-14,22,24,31H,15-20H2,(H,29,33)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130535
PNG
(CHEMBL3632695)
Show SMILES OC(=O)\C=C\C(O)=O.COc1cc(ccc1COCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1/C25H29F3N2O4.C4H4O4/c1-33-23-12-19(25(26,27)28)7-6-18(23)15-34-16-21(31)14-29-10-8-20(9-11-29)30-13-17-4-2-3-5-22(17)24(30)32;5-3(6)1-2-4(7)8/h2-7,12,20-21,31H,8-11,13-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130521
PNG
(CHEMBL3634329)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-24(20-35-27-13-7-6-12-26(27)28(33)21-8-2-1-3-9-21)19-30-16-14-23(15-17-30)31-18-22-10-4-5-11-25(22)29(31)34/h1-13,23-24,32H,14-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130531
PNG
(CHEMBL3632691)
Show SMILES OC(COc1cccc(c1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C23H25F3N2O3/c24-23(25,26)17-5-3-6-20(12-17)31-15-19(29)14-27-10-8-18(9-11-27)28-13-16-4-1-2-7-21(16)22(28)30/h1-7,12,18-19,29H,8-11,13-15H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50130525
PNG
(CHEMBL3632641)
Show SMILES OC(COc1ccc(cc1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-25(20-35-26-12-10-22(11-13-26)28(33)21-6-2-1-3-7-21)19-30-16-14-24(15-17-30)31-18-23-8-4-5-9-27(23)29(31)34/h1-13,24-25,32H,14-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.5 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130529
PNG
(CHEMBL3634336)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N2Cc3ccccc3C2=O)cc1
Show InChI InChI=1/C23H28N2O4/c1-28-20-6-8-21(9-7-20)29-16-19(26)15-24-12-10-18(11-13-24)25-14-17-4-2-3-5-22(17)23(25)27/h2-9,18-19,26H,10-16H2,1H3
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130514
PNG
(CHEMBL3634324)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)c1cccc2NC(=O)CCc12
Show InChI InChI=1/C30H32N2O4/c33-23(20-36-28-12-5-4-9-26(28)30(35)22-7-2-1-3-8-22)19-32-17-15-21(16-18-32)24-10-6-11-27-25(24)13-14-29(34)31-27/h1-12,21,23,33H,13-20H2,(H,31,34)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130510
PNG
(CHEMBL3632698)
Show SMILES COc1cc(ccc1COCC(O)CN1CCC(CC1)C(=O)Nc1ccccc1)C(F)(F)F
Show InChI InChI=1/C24H29F3N2O4/c1-32-22-13-19(24(25,26)27)8-7-18(22)15-33-16-21(30)14-29-11-9-17(10-12-29)23(31)28-20-5-3-2-4-6-20/h2-8,13,17,21,30H,9-12,14-16H2,1H3,(H,28,31)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130518
PNG
(CHEMBL3634326)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)N1C(=O)COc2ccccc12
Show InChI InChI=1/C29H30N2O5/c32-23(19-35-26-12-6-4-10-24(26)29(34)21-8-2-1-3-9-21)18-30-16-14-22(15-17-30)31-25-11-5-7-13-27(25)36-20-28(31)33/h1-13,22-23,32H,14-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130528
PNG
(CHEMBL3634335)
Show SMILES COc1cccc(OCC(O)CN2CCC(CC2)N2Cc3ccccc3C2=O)c1
Show InChI InChI=1/C23H28N2O4/c1-28-20-6-4-7-21(13-20)29-16-19(26)15-24-11-9-18(10-12-24)25-14-17-5-2-3-8-22(17)23(25)27/h2-8,13,18-19,26H,9-12,14-16H2,1H3
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130534
PNG
(CHEMBL3632694)
Show SMILES OC(COCc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C24H27F3N2O3/c25-24(26,27)19-7-5-17(6-8-19)15-32-16-21(30)14-28-11-9-20(10-12-28)29-13-18-3-1-2-4-22(18)23(29)31/h1-8,20-21,30H,9-16H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130521
PNG
(CHEMBL3634329)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C29H30N2O4/c32-24(20-35-27-13-7-6-12-26(27)28(33)21-8-2-1-3-9-21)19-30-16-14-23(15-17-30)31-18-22-10-4-5-11-25(22)29(31)34/h1-13,23-24,32H,14-20H2
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130535
PNG
(CHEMBL3632695)
Show SMILES OC(=O)\C=C\C(O)=O.COc1cc(ccc1COCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1/C25H29F3N2O4.C4H4O4/c1-33-23-12-19(25(26,27)28)7-6-18(23)15-34-16-21(31)14-29-10-8-20(9-11-29)30-13-17-4-2-3-5-22(17)24(30)32;5-3(6)1-2-4(7)8/h2-7,12,20-21,31H,8-11,13-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130510
PNG
(CHEMBL3632698)
Show SMILES COc1cc(ccc1COCC(O)CN1CCC(CC1)C(=O)Nc1ccccc1)C(F)(F)F
Show InChI InChI=1/C24H29F3N2O4/c1-32-22-13-19(24(25,26)27)8-7-18(22)15-33-16-21(30)14-29-11-9-17(10-12-29)23(31)28-20-5-3-2-4-6-20/h2-8,13,17,21,30H,9-12,14-16H2,1H3,(H,28,31)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130519
PNG
(CHEMBL3634327)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)n1c2ccccc2oc1=O
Show InChI InChI=1/C28H28N2O5/c31-22(19-34-25-12-6-4-10-23(25)27(32)20-8-2-1-3-9-20)18-29-16-14-21(15-17-29)30-24-11-5-7-13-26(24)35-28(30)33/h1-13,21-22,31H,14-19H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130532
PNG
(CHEMBL3632692)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)N1Cc2ccccc2C1=O
Show InChI InChI=1/C23H25F3N2O3/c24-23(25,26)17-5-7-20(8-6-17)31-15-19(29)14-27-11-9-18(10-12-27)28-13-16-3-1-2-4-21(16)22(28)30/h1-8,18-19,29H,9-15H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50130529
PNG
(CHEMBL3634336)
Show SMILES COc1ccc(OCC(O)CN2CCC(CC2)N2Cc3ccccc3C2=O)cc1
Show InChI InChI=1/C23H28N2O4/c1-28-20-6-8-21(9-7-20)29-16-19(26)15-24-12-10-18(11-13-24)25-14-17-4-2-3-5-22(17)23(25)27/h2-9,18-19,26H,10-16H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50130523
PNG
(CHEMBL3634331)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1/C28H30N2O4/c31-24(19-30-17-15-22(16-18-30)28(33)29-23-11-5-2-6-12-23)20-34-26-14-8-7-13-25(26)27(32)21-9-3-1-4-10-21/h1-14,22,24,31H,15-20H2,(H,29,33)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.5 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130512
PNG
(CHEMBL3634322)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCC(CC1)c1cccc2NC(=O)COc12
Show InChI InChI=1/C29H30N2O5/c32-22(18-35-26-12-5-4-9-24(26)28(34)21-7-2-1-3-8-21)17-31-15-13-20(14-16-31)23-10-6-11-25-29(23)36-19-27(33)30-25/h1-12,20,22,32H,13-19H2,(H,30,33)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel alpha subunit Nav1.1


(Mus musculus)
BDBM50130510
PNG
(CHEMBL3632698)
Show SMILES COc1cc(ccc1COCC(O)CN1CCC(CC1)C(=O)Nc1ccccc1)C(F)(F)F
Show InChI InChI=1/C24H29F3N2O4/c1-32-22-13-19(24(25,26)27)8-7-18(22)15-33-16-21(30)14-29-11-9-17(10-12-29)23(31)28-20-5-3-2-4-6-20/h2-8,13,17,21,30H,9-12,14-16H2,1H3,(H,28,31)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Mus musculus)
BDBM50130513
PNG
(CHEMBL3634323)
Show SMILES OC(COc1ccccc1C(=O)c1ccccc1)CN1CCN(CC1)c1cccc2NC(=O)CCc12
Show InChI InChI=1/C29H31N3O4/c33-22(20-36-27-12-5-4-9-24(27)29(35)21-7-2-1-3-8-21)19-31-15-17-32(18-16-31)26-11-6-10-25-23(26)13-14-28(34)30-25/h1-12,22,33H,13-20H2,(H,30,34)
PDB

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n/an/a 2.40E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
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