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Compile Data Set for Download or QSAR

Found 505 hits with Last Name = 'bauman' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM209866
PNG
(PF-06651600 | US9617258, Example 5)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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0.0269n/an/an/an/an/an/a7.5n/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)


Article DOI: 10.1021/acschembio.6b00677
BindingDB Entry DOI: 10.7270/Q2PN94F8
More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK (TXK)


(Homo sapiens (Human))
BDBM209866
PNG
(PF-06651600 | US9617258, Example 5)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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0.131n/an/an/an/an/an/a7.5n/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)


Article DOI: 10.1021/acschembio.6b00677
BindingDB Entry DOI: 10.7270/Q2PN94F8
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BMX


(Homo sapiens (Human))
BDBM209866
PNG
(PF-06651600 | US9617258, Example 5)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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0.545n/an/an/an/an/an/a7.5n/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)


Article DOI: 10.1021/acschembio.6b00677
BindingDB Entry DOI: 10.7270/Q2PN94F8
More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Homo sapiens (Human))
BDBM209866
PNG
(PF-06651600 | US9617258, Example 5)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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0.679n/an/an/an/an/an/a7.5n/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)


Article DOI: 10.1021/acschembio.6b00677
BindingDB Entry DOI: 10.7270/Q2PN94F8
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082670
PNG
(4-(4-Chloro-phenyl)-1-(4,4-diphenyl-butyl)-4-hydro...)
Show SMILES C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(CC1)c1ccc(Cl)cc1 |(4.39,-16.36,;5.59,-14.67,;4.76,-13.8,;4.76,-12.26,;3.43,-11.48,;3.43,-9.94,;2.64,-8.61,;3.41,-7.25,;2.64,-5.9,;1.07,-5.91,;.3,-7.26,;1.09,-8.61,;2.1,-10.69,;2.06,-12.23,;.74,-12.97,;-.6,-12.19,;-.58,-10.65,;.77,-9.89,;6.81,-15.92,;8.35,-15.99,;9.17,-14.69,;10.24,-13.6,;8.45,-13.32,;6.91,-13.28,;10.24,-15.76,;9.85,-17.24,;10.92,-18.3,;12.38,-17.91,;13.45,-19,;12.78,-16.43,;11.71,-15.38,)|
Show InChI InChI=1S/C28H33ClNO/c1-30(21-18-28(31,19-22-30)25-14-16-26(29)17-15-25)20-8-13-27(23-9-4-2-5-10-23)24-11-6-3-7-12-24/h2-7,9-12,14-17,27,31H,8,13,18-22H2,1H3/q+1
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6n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM50398061
PNG
(CHEMBL2181928)
Show SMILES C[C@@H]1CN([C@@H](CO1)c1ccccc1)c1ccc2OCC(=O)Nc2n1 |r|
Show InChI InChI=1S/C18H19N3O3/c1-12-9-21(14(10-23-12)13-5-3-2-4-6-13)16-8-7-15-18(19-16)20-17(22)11-24-15/h2-8,12,14H,9-11H2,1H3,(H,19,20,22)/t12-,14+/m1/s1
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6.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL




J Med Chem 61: 1086-1097 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM209866
PNG
(PF-06651600 | US9617258, Example 5)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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6.31n/an/an/an/an/an/a7.5n/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)


Article DOI: 10.1021/acschembio.6b00677
BindingDB Entry DOI: 10.7270/Q2PN94F8
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082715
PNG
(4-(4-Chloro-phenyl)-1-(4-cyano-4,4-diphenyl-butyl)...)
Show SMILES C[N+]1(CCCC(C#N)(c2ccccc2)c2ccccc2)CCC(O)(CC1)c1ccc(Cl)cc1 |(5.21,-30.15,;6.41,-28.45,;5.58,-27.59,;5.59,-26.05,;4.24,-25.28,;4.24,-23.74,;5.74,-23.32,;7.21,-22.9,;2.92,-24.5,;2.9,-26.01,;1.55,-26.77,;.22,-25.98,;.24,-24.44,;1.58,-23.7,;3.46,-22.39,;1.9,-22.41,;1.13,-21.07,;1.9,-19.7,;3.46,-19.7,;4.24,-21.04,;7.74,-27.07,;9.28,-27.13,;9.98,-28.48,;11.06,-27.39,;9.18,-29.79,;7.64,-29.72,;11.06,-29.56,;10.66,-31.02,;11.74,-32.1,;13.19,-31.71,;14.27,-32.78,;13.6,-30.24,;12.52,-29.16,)|
Show InChI InChI=1S/C29H32ClN2O/c1-32(21-18-29(33,19-22-32)26-13-15-27(30)16-14-26)20-8-17-28(23-31,24-9-4-2-5-10-24)25-11-6-3-7-12-25/h2-7,9-16,33H,8,17-22H2,1H3/q+1
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8n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082729
PNG
(1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC(CNC(=O)NC2CCNCC2)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H43ClN4O2/c35-30-14-12-29(13-15-30)34(41)19-24-39(25-20-34)23-7-18-33(27-8-3-1-4-9-27,28-10-5-2-6-11-28)26-37-32(40)38-31-16-21-36-22-17-31/h1-6,8-15,31,36,41H,7,16-26H2,(H2,37,38,40)
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9n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082682
PNG
(5-{3-[4-(4-Bromo-phenyl)-4-hydroxy-piperidin-1-yl]...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CSc3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C29H29BrN2OS/c30-24-12-10-23(11-13-24)29(33)15-18-32(19-16-29)17-5-14-28(21-31)25-7-2-1-6-22(25)20-34-27-9-4-3-8-26(27)28/h1-4,6-13,33H,5,14-20H2
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22n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082694
PNG
(4-(4-Chloro-phenyl)-1-(4-cyano-4-naphthalen-2-yl-b...)
Show SMILES C[N+]1(CCCC(C#N)c2ccc3ccccc3c2)CCC(O)(CC1)c1ccc(Cl)cc1 |(5.16,-16.1,;5.58,-14.63,;4.75,-13.77,;4.75,-12.23,;3.42,-11.45,;3.42,-9.92,;4.75,-9.13,;6.06,-8.35,;2.63,-8.58,;1.09,-8.58,;.3,-7.24,;1.07,-5.9,;.29,-4.55,;1.06,-3.2,;2.6,-3.18,;3.39,-4.52,;2.62,-5.89,;3.4,-7.23,;6.79,-15.88,;8.33,-15.94,;9.15,-14.65,;10.22,-13.57,;8.43,-13.29,;6.89,-13.25,;10.22,-15.72,;9.82,-17.19,;10.89,-18.25,;12.35,-17.86,;13.42,-18.95,;12.74,-16.39,;11.68,-15.34,)|
Show InChI InChI=1S/C27H30ClN2O/c1-30(17-14-27(31,15-18-30)25-10-12-26(28)13-11-25)16-4-7-24(20-29)23-9-8-21-5-2-3-6-22(21)19-23/h2-3,5-6,8-13,19,24,31H,4,7,14-18H2,1H3/q+1
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22n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082671
PNG
(5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CSc3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H29ClN2OS/c30-24-12-10-23(11-13-24)29(33)15-18-32(19-16-29)17-5-14-28(21-31)25-7-2-1-6-22(25)20-34-27-9-4-3-8-26(27)28/h1-4,6-13,33H,5,14-20H2
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24n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082737
PNG
(9-{3-[4-(4-Bromo-phenyl)-4-hydroxy-piperidin-1-yl]...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3Cc3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C29H29BrN2O/c30-25-12-10-24(11-13-25)29(33)15-18-32(19-16-29)17-5-14-28(21-31)26-8-3-1-6-22(26)20-23-7-2-4-9-27(23)28/h1-4,6-13,33H,5,14-20H2
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29n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082690
PNG
(11-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-y...)
Show SMILES CN1c2ccccc2C(CCCN2CCC(O)(CC2)c2ccc(Cl)cc2)(C#N)c2ccccc2C1=O
Show InChI InChI=1S/C30H30ClN3O2/c1-33-27-10-5-4-9-26(27)29(21-32,25-8-3-2-7-24(25)28(33)35)15-6-18-34-19-16-30(36,17-20-34)22-11-13-23(31)14-12-22/h2-5,7-14,36H,6,15-20H2,1H3
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32n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM209866
PNG
(PF-06651600 | US9617258, Example 5)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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32.4n/an/an/an/an/an/a7.5n/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)


Article DOI: 10.1021/acschembio.6b00677
BindingDB Entry DOI: 10.7270/Q2PN94F8
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082720
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES CCOC(=O)C(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)(C#N)c1ccccc1
Show InChI InChI=1S/C25H29ClN2O3/c1-2-31-23(29)24(19-27,20-7-4-3-5-8-20)13-6-16-28-17-14-25(30,15-18-28)21-9-11-22(26)12-10-21/h3-5,7-12,30H,2,6,13-18H2,1H3
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33n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082706
PNG
(11-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-y...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3COc3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H29ClN2O2/c30-24-12-10-23(11-13-24)29(33)15-18-32(19-16-29)17-5-14-28(21-31)25-7-2-1-6-22(25)20-34-27-9-4-3-8-26(27)28/h1-4,6-13,33H,5,14-20H2
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34n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082705
PNG
(5-{3-[4-(4-Fluoro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CSc3ccccc23)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C29H29FN2OS/c30-24-12-10-23(11-13-24)29(33)15-18-32(19-16-29)17-5-14-28(21-31)25-7-2-1-6-22(25)20-34-27-9-4-3-8-26(27)28/h1-4,6-13,33H,5,14-20H2
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44n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082688
PNG
(5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CCc3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H31ClN2O/c31-26-14-12-25(13-15-26)30(34)17-20-33(21-18-30)19-5-16-29(22-32)27-8-3-1-6-23(27)10-11-24-7-2-4-9-28(24)29/h1-4,6-9,12-15,34H,5,10-11,16-21H2
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45n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082668
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES OC1(CCN(CCCC(CCCCl)(C#N)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H30Cl2N2O/c26-16-4-12-24(20-28,21-6-2-1-3-7-21)13-5-17-29-18-14-25(30,15-19-29)22-8-10-23(27)11-9-22/h1-3,6-11,30H,4-5,12-19H2
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51n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50027216
PNG
(5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...)
Show SMILES OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H29ClN2O/c29-26-14-12-25(13-15-26)28(32)17-20-31(21-18-28)19-7-16-27(22-30,23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15,32H,7,16-21H2
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52n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082716
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES COC(=O)C(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)(C#N)c1ccccc1
Show InChI InChI=1S/C24H27ClN2O3/c1-30-22(28)23(18-26,19-6-3-2-4-7-19)12-5-15-27-16-13-24(29,14-17-27)20-8-10-21(25)11-9-20/h2-4,6-11,29H,5,12-17H2,1H3
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53n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082692
PNG
(5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CS(=O)c3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H29ClN2O2S/c30-24-12-10-23(11-13-24)29(33)15-18-32(19-16-29)17-5-14-28(21-31)25-7-2-1-6-22(25)20-35(34)27-9-4-3-8-26(27)28/h1-4,6-13,33H,5,14-20H2
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54n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082733
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES OC1(CCN(CCCC(C#N)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClN2O/c23-21-10-8-20(9-11-21)22(26)12-15-25(16-13-22)14-4-7-19(17-24)18-5-2-1-3-6-18/h1-3,5-6,8-11,19,26H,4,7,12-16H2
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54n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082674
PNG
(5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3C=Cc3ccccc23)CC1)c1ccc(Cl)cc1 |c:18|
Show InChI InChI=1S/C30H29ClN2O/c31-26-14-12-25(13-15-26)30(34)17-20-33(21-18-30)19-5-16-29(22-32)27-8-3-1-6-23(27)10-11-24-7-2-4-9-28(24)29/h1-4,6-15,34H,5,16-21H2
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56n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM209866
PNG
(PF-06651600 | US9617258, Example 5)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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62.3n/an/an/an/an/an/a7.5n/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)


Article DOI: 10.1021/acschembio.6b00677
BindingDB Entry DOI: 10.7270/Q2PN94F8
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082692
PNG
(5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CS(=O)c3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H29ClN2O2S/c30-24-12-10-23(11-13-24)29(33)15-18-32(19-16-29)17-5-14-28(21-31)25-7-2-1-6-22(25)20-35(34)27-9-4-3-8-26(27)28/h1-4,6-13,33H,5,14-20H2
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71n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082701
PNG
(2-(3-Bromo-4-methoxy-phenyl)-5-[4-(4-chloro-phenyl...)
Show SMILES COc1ccc(cc1Br)C(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)C#N
Show InChI InChI=1S/C23H26BrClN2O2/c1-29-22-9-4-17(15-21(22)24)18(16-26)3-2-12-27-13-10-23(28,11-14-27)19-5-7-20(25)8-6-19/h4-9,15,18,28H,2-3,10-14H2,1H3
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74n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082691
PNG
(6-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES OC1(CCN(CCCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN2O/c30-27-15-13-26(14-16-27)29(33)18-21-32(22-19-29)20-8-7-17-28(23-31,24-9-3-1-4-10-24)25-11-5-2-6-12-25/h1-6,9-16,33H,7-8,17-22H2
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78n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082676
PNG
(4-[1-(4-Cyano-4,4-diphenyl-butyl)-4-hydroxy-piperi...)
Show SMILES OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H29N3O/c30-22-24-12-14-27(15-13-24)29(33)17-20-32(21-18-29)19-7-16-28(23-31,25-8-3-1-4-9-25)26-10-5-2-6-11-26/h1-6,8-15,33H,7,16-21H2
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92n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082723
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES CCC(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)(C#N)c1ccccc1
Show InChI InChI=1S/C24H29ClN2O/c1-2-23(19-26,20-7-4-3-5-8-20)13-6-16-27-17-14-24(28,15-18-27)21-9-11-22(25)12-10-21/h3-5,7-12,28H,2,6,13-18H2,1H3
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93n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082717
PNG
(2-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC(C#N)c2ccccc2C#N)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H24ClN3O/c24-21-9-7-20(8-10-21)23(28)11-14-27(15-12-23)13-3-5-19(17-26)22-6-2-1-4-18(22)16-25/h1-2,4,6-10,19,28H,3,5,11-15H2
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98n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082703
PNG
(7-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES OC1(CCN(CCCCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H33ClN2O/c31-28-16-14-27(15-17-28)30(34)19-22-33(23-20-30)21-9-3-8-18-29(24-32,25-10-4-1-5-11-25)26-12-6-2-7-13-26/h1-2,4-7,10-17,34H,3,8-9,18-23H2
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99n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082730
PNG
(4-(4-Chloro-phenyl)-1-(4,4-diphenyl-butyl)-4-hydro...)
Show SMILES OC1(CC[NH+](CCCC(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1 |(10.24,-13.6,;9.18,-14.69,;8.45,-13.32,;6.91,-13.28,;5.59,-14.67,;4.76,-13.81,;4.76,-12.27,;3.43,-11.48,;3.43,-9.94,;2.64,-8.61,;3.41,-7.25,;2.64,-5.9,;1.07,-5.91,;.3,-7.26,;1.09,-8.61,;2.1,-10.69,;2.06,-12.23,;.74,-12.97,;-.6,-12.19,;-.58,-10.65,;.77,-9.89,;6.81,-15.92,;8.35,-15.99,;10.24,-15.76,;9.85,-17.24,;10.92,-18.3,;12.38,-17.91,;13.45,-19,;12.78,-16.44,;11.71,-15.38,)|
Show InChI InChI=1S/C27H30ClNO/c28-25-15-13-24(14-16-25)27(30)17-20-29(21-18-27)19-7-12-26(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-11,13-16,26,30H,7,12,17-21H2/p+1
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116n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082675
PNG
(2-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC(CC#N)(C#N)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H26ClN3O/c25-22-9-7-21(8-10-22)24(29)13-17-28(18-14-24)16-4-11-23(19-27,12-15-26)20-5-2-1-3-6-20/h1-3,5-10,29H,4,11-14,16-18H2
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125n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082713
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES OC1(CCN(CCCC(C#N)c2cccs2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClN2OS/c21-18-7-5-17(6-8-18)20(24)9-12-23(13-10-20)11-1-3-16(15-22)19-4-2-14-25-19/h2,4-8,14,16,24H,1,3,9-13H2
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128n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082673
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES OC1(CCN(CCCC(C#N)(N2CCCCC2)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H34ClN3O/c28-25-12-10-24(11-13-25)27(32)15-20-30(21-16-27)17-7-14-26(22-29,23-8-3-1-4-9-23)31-18-5-2-6-19-31/h1,3-4,8-13,32H,2,5-7,14-21H2
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130n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50408773
PNG
(CHEMBL2112832)
Show SMILES OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H29FN2O/c29-26-14-12-25(13-15-26)28(32)17-20-31(21-18-28)19-7-16-27(22-30,23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15,32H,7,16-21H2
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136n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082709
PNG
(5-[4-Hydroxy-4-(4-trifluoromethyl-phenyl)-piperidi...)
Show SMILES OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H29F3N2O/c30-29(31,32)26-14-12-25(13-15-26)28(35)17-20-34(21-18-28)19-7-16-27(22-33,23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15,35H,7,16-21H2
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153n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082678
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES Oc1cccc(c1)C(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)C#N
Show InChI InChI=1S/C22H25ClN2O2/c23-20-8-6-19(7-9-20)22(27)10-13-25(14-11-22)12-2-4-18(16-24)17-3-1-5-21(26)15-17/h1,3,5-9,15,18,26-27H,2,4,10-14H2
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156n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082687
PNG
(5-[3-(4-Hydroxy-4-o-tolyl-piperidin-1-yl)-propyl]-...)
Show SMILES Cc1ccccc1C1(O)CCN(CCCC2(C#N)c3ccccc3CSc3ccccc23)CC1
Show InChI InChI=1S/C30H32N2OS/c1-23-9-2-4-11-25(23)30(33)16-19-32(20-17-30)18-8-15-29(22-31)26-12-5-3-10-24(26)21-34-28-14-7-6-13-27(28)29/h2-7,9-14,33H,8,15-21H2,1H3
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164n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082698
PNG
(5-[3-(4-Hydroxy-4-phenyl-piperidin-1-yl)-propyl]-5...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CSc3ccccc23)CC1)c1ccccc1
Show InChI InChI=1S/C29H30N2OS/c30-22-28(25-12-5-4-9-23(25)21-33-27-14-7-6-13-26(27)28)15-8-18-31-19-16-29(32,17-20-31)24-10-2-1-3-11-24/h1-7,9-14,32H,8,15-21H2
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203n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082680
PNG
(4-(4-Chloro-phenyl)-1-(4-cyano-4-naphthalen-2-yl-b...)
Show SMILES OC1(CC[NH+](CCCC(C#N)c2ccc3ccccc3c2)CC1)c1ccc(Cl)cc1 |(10.22,-13.57,;9.15,-14.65,;8.43,-13.29,;6.89,-13.25,;5.58,-14.63,;4.75,-13.77,;4.75,-12.23,;3.42,-11.45,;3.42,-9.92,;4.75,-9.13,;6.06,-8.35,;2.63,-8.58,;1.09,-8.58,;.3,-7.24,;1.07,-5.9,;.29,-4.55,;1.06,-3.2,;2.6,-3.18,;3.39,-4.52,;2.62,-5.89,;3.4,-7.23,;6.79,-15.88,;8.33,-15.94,;10.22,-15.72,;9.82,-17.19,;10.89,-18.25,;12.35,-17.86,;13.42,-18.95,;12.74,-16.39,;11.68,-15.34,)|
Show InChI InChI=1S/C26H27ClN2O/c27-25-11-9-24(10-12-25)26(30)13-16-29(17-14-26)15-3-6-23(19-28)22-8-7-20-4-1-2-5-21(20)18-22/h1-2,4-5,7-12,18,23,30H,3,6,13-17H2/p+1
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206n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082725
PNG
(5-(4'-Hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bip...)
Show SMILES OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1cccnc1
Show InChI InChI=1S/C27H29N3O/c28-22-26(23-9-3-1-4-10-23,24-11-5-2-6-12-24)14-8-18-30-19-15-27(31,16-20-30)25-13-7-17-29-21-25/h1-7,9-13,17,21,31H,8,14-16,18-20H2
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206n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082677
PNG
(5-{3-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydr...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3CSc3ccccc23)CC1)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C30H28ClF3N2OS/c31-26-11-10-22(18-25(26)30(32,33)34)29(37)13-16-36(17-14-29)15-5-12-28(20-35)23-7-2-1-6-21(23)19-38-27-9-4-3-8-24(27)28/h1-4,6-11,18,37H,5,12-17,19H2
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224n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082689
PNG
(5-[4-Hydroxy-4-(4-iodo-phenyl)-piperidin-1-yl]-2,2...)
Show SMILES OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(I)cc1
Show InChI InChI=1S/C28H29IN2O/c29-26-14-12-25(13-15-26)28(32)17-20-31(21-18-28)19-7-16-27(22-30,23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15,32H,7,16-21H2
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233n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082728
PNG
(9-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCC2(C#N)c3ccccc3Oc3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H27ClN2O2/c29-22-12-10-21(11-13-22)28(32)15-18-31(19-16-28)17-5-14-27(20-30)23-6-1-3-8-25(23)33-26-9-4-2-7-24(26)27/h1-4,6-13,32H,5,14-19H2
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234n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082700
PNG
(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Show SMILES OC1(CCN(CCCC(C#N)c2ccsc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClN2OS/c21-19-5-3-18(4-6-19)20(24)8-11-23(12-9-20)10-1-2-16(14-22)17-7-13-25-15-17/h3-7,13,15-16,24H,1-2,8-12H2
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236n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082711
PNG
(1-(5-Amino-4,4-diphenyl-pentyl)-4-(4-chloro-phenyl...)
Show SMILES NCC(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H33ClN2O/c29-26-14-12-25(13-15-26)28(32)17-20-31(21-18-28)19-7-16-27(22-30,23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15,32H,7,16-22,30H2
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244n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))
BDBM50082707
PNG
(2-(2-Chloro-phenyl)-5-[4-(4-chloro-phenyl)-4-hydro...)
Show SMILES OC1(CCN(CCCC(C#N)c2ccccc2Cl)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N2O/c23-19-9-7-18(8-10-19)22(27)11-14-26(15-12-22)13-3-4-17(16-25)20-5-1-2-6-21(20)24/h1-2,5-10,17,27H,3-4,11-15H2
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306n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells


J Med Chem 42: 4680-94 (1999)


BindingDB Entry DOI: 10.7270/Q2125TCC
More data for this
Ligand-Target Pair
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