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Compile Data Set for Download or QSAR

Found 164 hits with Last Name = 'baumann' and Initial = 'ca'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318372
PNG
((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-meth...)
Show SMILES CO\N=C1/CCCC(=C1)C#Cc1ccccn1 |c:7|
Show InChI InChI=1S/C14H14N2O/c1-17-16-14-7-4-5-12(11-14)8-9-13-6-2-3-10-15-13/h2-3,6,10-11H,4-5,7H2,1H3/b16-14+
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2.20n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11123
PNG
((2S)-1-[(2S)-2-amino-3-[4-(2,4-difluorophenyl)phen...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccc(F)cc1F)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C20H19F2N3O/c21-15-7-8-17(18(22)11-15)14-5-3-13(4-6-14)10-19(24)20(26)25-9-1-2-16(25)12-23/h3-8,11,16,19H,1-2,9-10,24H2/t16-,19-/m0/s1
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2.20 -49.4n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11121
PNG
((2S)-1-[(2S)-2-amino-3-[4-(4-fluorophenyl)phenyl]p...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C20H20FN3O/c21-17-9-7-16(8-10-17)15-5-3-14(4-6-15)12-19(23)20(25)24-11-1-2-18(24)13-22/h3-10,18-19H,1-2,11-12,23H2/t18-,19-/m0/s1
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3.10 -48.6n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318382
PNG
(3-[pyridine-2-yl)ethynyl]cyclohex-2-enone-O-fluoro...)
Show SMILES FCCOCCO\N=C1/CCCC(=C1)C#Cc1ccccn1 |c:12|
Show InChI InChI=1S/C17H19FN2O2/c18-9-11-21-12-13-22-20-17-6-3-4-15(14-17)7-8-16-5-1-2-10-19-16/h1-2,5,10,14H,3-4,6,9,11-13H2/b20-17+
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3.80n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318375
PNG
((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-3-fl...)
Show SMILES Fc1cccnc1O\N=C1/CCCC(=C1)C#Cc1ccccn1 |c:14|
Show InChI InChI=1S/C18H14FN3O/c19-17-8-4-12-21-18(17)23-22-16-7-3-5-14(13-16)9-10-15-6-1-2-11-20-15/h1-2,4,6,8,11-13H,3,5,7H2/b22-16+
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4.01n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50198702
PNG
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Show SMILES CO\N=C1/CCCC(=C1)C#Cc1cccc(C)n1 |c:7|
Show InChI InChI=1S/C15H16N2O/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-18-2/h3,5,7,11H,4,6,8H2,1-2H3/b17-15+
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4.40n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11122
PNG
((2S)-1-[(2S)-2-amino-3-[4-(2-fluorophenyl)phenyl]p...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1F)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C20H20FN3O/c21-18-6-2-1-5-17(18)15-9-7-14(8-10-15)12-19(23)20(25)24-11-3-4-16(24)13-22/h1-2,5-10,16,19H,3-4,11-12,23H2/t16-,19-/m0/s1
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5.30 -47.2n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318381
PNG
((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-f...)
Show SMILES FCCCOCO\N=C1/CCCC(=C1)C#Cc1ccccn1 |c:12|
Show InChI InChI=1S/C17H19FN2O2/c18-10-4-12-21-14-22-20-17-7-3-5-15(13-17)8-9-16-6-1-2-11-19-16/h1-2,6,11,13H,3-5,7,10,12,14H2/b20-17+
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5.42n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50323923
PNG
((E)-3-((2-(Fluoromethyl)thiazol-4-yl)ethynyl)cyclo...)
Show SMILES CO\N=C1/CCCC(=C1)C#Cc1csc(CF)n1 |c:7|
Show InChI InChI=1S/C13H13FN2OS/c1-17-16-11-4-2-3-10(7-11)5-6-12-9-18-13(8-14)15-12/h7,9H,2-4,8H2,1H3/b16-11+
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5.5n/an/an/an/an/an/an/an/a



ETH Zurich (Swiss Federal Institute of Technology)

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation counting


Bioorg Med Chem 18: 6044-54 (2010)


Article DOI: 10.1016/j.bmc.2010.06.070
BindingDB Entry DOI: 10.7270/Q2862GMS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318380
PNG
((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(2-f...)
Show SMILES FCCOCO\N=C1/CCCC(=C1)C#Cc1ccccn1 |c:11|
Show InChI InChI=1S/C16H17FN2O2/c17-9-11-20-13-21-19-16-6-3-4-14(12-16)7-8-15-5-1-2-10-18-15/h1-2,5,10,12H,3-4,6,9,11,13H2/b19-16+
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8.41n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318374
PNG
((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-6-fl...)
Show SMILES Fc1cccc(O\N=C2/CCCC(=C2)C#Cc2ccccn2)n1 |c:12|
Show InChI InChI=1S/C18H14FN3O/c19-17-8-4-9-18(21-17)23-22-16-7-3-5-14(13-16)10-11-15-6-1-2-12-20-15/h1-2,4,6,8-9,12-13H,3,5,7H2/b22-16+
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9.15n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11118
PNG
((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C20H21N3O/c21-14-18-7-4-12-23(18)20(24)19(22)13-15-8-10-17(11-9-15)16-5-2-1-3-6-16/h1-3,5-6,8-11,18-19H,4,7,12-13,22H2/t18-,19-/m0/s1
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13 -45.0n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11119
PNG
((2S)-1-[(2S)-2-amino-3-[4-(4-methylphenyl)phenyl]p...)
Show SMILES Cc1ccc(cc1)-c1ccc(C[C@H](N)C(=O)N2CCC[C@H]2C#N)cc1 |r|
Show InChI InChI=1S/C21H23N3O/c1-15-4-8-17(9-5-15)18-10-6-16(7-11-18)13-20(23)21(25)24-12-2-3-19(24)14-22/h4-11,19-20H,2-3,12-13,23H2,1H3/t19-,20-/m0/s1
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20 -43.9n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50323924
PNG
((E)-3-(Thiazol-2-ylethynyl)cyclohex-2-enone O-meth...)
Show SMILES CO\N=C1/CCCC(=C1)C#Cc1nccs1 |c:7|
Show InChI InChI=1S/C12H12N2OS/c1-15-14-11-4-2-3-10(9-11)5-6-12-13-7-8-16-12/h7-9H,2-4H2,1H3/b14-11+
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20.3n/an/an/an/an/an/an/an/a



ETH Zurich (Swiss Federal Institute of Technology)

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation counting


Bioorg Med Chem 18: 6044-54 (2010)


Article DOI: 10.1016/j.bmc.2010.06.070
BindingDB Entry DOI: 10.7270/Q2862GMS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50323926
PNG
((E)-3-((2-Methylthiazol-4-yl)ethynyl)cyclohex-2-en...)
Show SMILES Cc1nc(cs1)C#CC1=C\C(CCC1)=N\OCCOCCF |t:9|
Show InChI InChI=1S/C16H19FN2O2S/c1-13-18-16(12-22-13)6-5-14-3-2-4-15(11-14)19-21-10-9-20-8-7-17/h11-12H,2-4,7-10H2,1H3/b19-15+
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21.9n/an/an/an/an/an/an/an/a



ETH Zurich (Swiss Federal Institute of Technology)

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation counting


Bioorg Med Chem 18: 6044-54 (2010)


Article DOI: 10.1016/j.bmc.2010.06.070
BindingDB Entry DOI: 10.7270/Q2862GMS
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11120
PNG
((2S)-1-[(2S)-2-amino-3-[4-(3,4-dimethoxyphenyl)phe...)
Show SMILES COc1ccc(cc1OC)-c1ccc(C[C@H](N)C(=O)N2CCC[C@H]2C#N)cc1 |r|
Show InChI InChI=1S/C22H25N3O3/c1-27-20-10-9-17(13-21(20)28-2)16-7-5-15(6-8-16)12-19(24)22(26)25-11-3-4-18(25)14-23/h5-10,13,18-19H,3-4,11-12,24H2,1-2H3/t18-,19-/m0/s1
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26 -43.3n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318383
PNG
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Show SMILES Cc1cccc(n1)C#CC1=C\C(CCC1)=N\OCCOCCF |t:10|
Show InChI InChI=1S/C18H21FN2O2/c1-15-4-2-6-17(20-15)9-8-16-5-3-7-18(14-16)21-23-13-12-22-11-10-19/h2,4,6,14H,3,5,7,10-13H2,1H3/b21-18+
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26.8n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11113
PNG
(6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Show SMILES O=C(CNCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C15H18N6O/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20)/t13-/m0/s1
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27 -43.2n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11116
PNG
((2S)-1-[(2S)-2-amino-3-(4-iodophenyl)propanoyl]pyr...)
Show SMILES N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C14H16IN3O/c15-11-5-3-10(4-6-11)8-13(17)14(19)18-7-1-2-12(18)9-16/h3-6,12-13H,1-2,7-8,17H2/t12-,13-/m0/s1
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34 -42.6n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50323925
PNG
((E)-3-(Thiazol-4-ylethynyl)cyclohex-2-enone O-2-(2...)
Show SMILES FCCOCCO\N=C1/CCCC(=C1)C#Cc1cscn1 |c:12|
Show InChI InChI=1S/C15H17FN2O2S/c16-6-7-19-8-9-20-18-14-3-1-2-13(10-14)4-5-15-11-21-12-17-15/h10-12H,1-3,6-9H2/b18-14+
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36n/an/an/an/an/an/an/an/a



ETH Zurich (Swiss Federal Institute of Technology)

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation counting


Bioorg Med Chem 18: 6044-54 (2010)


Article DOI: 10.1016/j.bmc.2010.06.070
BindingDB Entry DOI: 10.7270/Q2862GMS
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11124
PNG
((2S)-1-[(2S)-2-amino-3-[4-(furan-2-yl)phenyl]propa...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccco1)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C18H19N3O2/c19-12-15-3-1-9-21(15)18(22)16(20)11-13-5-7-14(8-6-13)17-4-2-10-23-17/h2,4-8,10,15-16H,1,3,9,11,20H2/t15-,16-/m0/s1
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36 -42.5n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318376
PNG
((Z)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-6-fl...)
Show SMILES Fc1cccc(O\N=C2\CCCC(=C2)C#Cc2ccccn2)n1 |c:12|
Show InChI InChI=1S/C18H14FN3O/c19-17-8-4-9-18(21-17)23-22-16-7-3-5-14(13-16)10-11-15-6-1-2-12-20-15/h1-2,4,6,8-9,12-13H,3,5,7H2/b22-16-
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44.0n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318373
PNG
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Show SMILES Cc1cccc(n1)C#CC1=C\C(CCC1)=N\Oc1cccc(F)n1 |t:10|
Show InChI InChI=1S/C19H16FN3O/c1-14-5-2-7-16(21-14)12-11-15-6-3-8-17(13-15)23-24-19-10-4-9-18(20)22-19/h2,4-5,7,9-10,13H,3,6,8H2,1H3/b23-17+
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46.8n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318377
PNG
((Z)-4-fluoro-2-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Show SMILES Fc1cc(O\N=C2\CCCC(=C2)C#Cc2ccccn2)ccc1C#N |c:10|
Show InChI InChI=1S/C20H14FN3O/c21-20-13-19(10-8-16(20)14-22)25-24-18-6-3-4-15(12-18)7-9-17-5-1-2-11-23-17/h1-2,5,8,10-13H,3-4,6H2/b24-18-
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49.8n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318371
PNG
((E)-3-(pyridin-4-ylethynyl)cyclohex-2-enone O-meth...)
Show SMILES CO\N=C1/CCCC(=C1)C#Cc1ccncc1 |c:7|
Show InChI InChI=1S/C14H14N2O/c1-17-16-14-4-2-3-13(11-14)6-5-12-7-9-15-10-8-12/h7-11H,2-4H2,1H3/b16-14+
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54.8n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318379
PNG
((E)-4-fluoro-2-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Show SMILES Fc1cc(O\N=C2/CCCC(=C2)C#Cc2ccccn2)ccc1C#N |c:10|
Show InChI InChI=1S/C20H14FN3O/c21-20-13-19(10-8-16(20)14-22)25-24-18-6-3-4-15(12-18)7-9-17-5-1-2-11-23-17/h1-2,5,8,10-13H,3-4,6H2/b24-18+
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56.1n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11115
PNG
((2S)-1-[(2S)-2-amino-3-phenylpropanoyl]pyrrolidine...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C14H17N3O/c15-10-12-7-4-8-17(12)14(18)13(16)9-11-5-2-1-3-6-11/h1-3,5-6,12-13H,4,7-9,16H2/t12-,13-/m0/s1
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63 -41.1n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318378
PNG
((E)-2-fluoro-4-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Show SMILES Fc1ccc(C#N)c(O\N=C2/CCCC(=C2)C#Cc2ccccn2)c1 |c:14|
Show InChI InChI=1S/C20H14FN3O/c21-17-9-8-16(14-22)20(13-17)25-24-19-6-3-4-15(12-19)7-10-18-5-1-2-11-23-18/h1-2,5,8-9,11-13H,3-4,6H2/b24-19+
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73.4n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11136
PNG
((2S)-2-amino-3-[4-(2,4-difluorophenyl)phenyl]-1-(1...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccc(F)cc1F)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C18H18F2N2OS/c19-14-5-6-15(16(20)10-14)13-3-1-12(2-4-13)9-17(21)18(23)22-7-8-24-11-22/h1-6,10,17H,7-9,11,21H2/t17-/m0/s1
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96 -40.1n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11134
PNG
(4-{4-[(2S)-2-amino-3-oxo-3-(1,3-thiazolidin-3-yl)p...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C19H19N3OS/c20-12-15-3-7-17(8-4-15)16-5-1-14(2-6-16)11-18(21)19(23)22-9-10-24-13-22/h1-8,18H,9-11,13,21H2/t18-/m0/s1
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160 -38.8n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11133
PNG
(3-{4-[(2S)-2-amino-3-oxo-3-(1,3-thiazolidin-3-yl)p...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cccc(c1)C(O)=O)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C19H20N2O3S/c20-17(18(22)21-8-9-25-12-21)10-13-4-6-14(7-5-13)15-2-1-3-16(11-15)19(23)24/h1-7,11,17H,8-10,12,20H2,(H,23,24)/t17-/m0/s1
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166 -38.7n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11135
PNG
((2S)-2-amino-3-[4-(4-fluorophenyl)phenyl]-1-(1,3-t...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C18H19FN2OS/c19-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(20)18(22)21-9-10-23-12-21/h1-8,17H,9-12,20H2/t17-/m0/s1
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170 -38.6n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50318370
PNG
((E)-3-(pyridin-3-ylethynyl)cyclohex-2-enone O-meth...)
Show SMILES CO\N=C1/CCCC(=C1)C#Cc1cccnc1 |c:7|
Show InChI InChI=1S/C14H14N2O/c1-17-16-14-6-2-4-12(10-14)7-8-13-5-3-9-15-11-13/h3,5,9-11H,2,4,6H2,1H3/b16-14+
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252n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11132
PNG
(4-{4-[(2S)-2-amino-3-oxo-3-(1,3-thiazolidin-3-yl)p...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C(O)=O)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C19H20N2O3S/c20-17(18(22)21-9-10-25-12-21)11-13-1-3-14(4-2-13)15-5-7-16(8-6-15)19(23)24/h1-8,17H,9-12,20H2,(H,23,24)/t17-/m0/s1
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310 -37.1n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11131
PNG
((2S)-2-amino-3-[4-(pyridin-2-yl)phenyl]-1-(1,3-thi...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccn1)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C17H19N3OS/c18-15(17(21)20-9-10-22-12-20)11-13-4-6-14(7-5-13)16-3-1-2-8-19-16/h1-8,15H,9-12,18H2/t15-/m0/s1
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355 -36.8n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11125
PNG
((2S)-2-amino-3-(4-phenylphenyl)-1-(1,3-thiazolidin...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C18H20N2OS/c19-17(18(21)20-10-11-22-13-20)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-13,19H2/t17-/m0/s1
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360 -36.8n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11117
PNG
(4-[(2S)-2-amino-3-[(2S)-2-cyanopyrrolidin-1-yl]-3-...)
Show SMILES N[C@@H](Cc1ccc(cc1)C(O)=O)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C15H17N3O3/c16-9-12-2-1-7-18(12)14(19)13(17)8-10-3-5-11(6-4-10)15(20)21/h3-6,12-13H,1-2,7-8,17H2,(H,20,21)/t12-,13-/m0/s1
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470 -36.1n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11130
PNG
((2S)-2-amino-3-(4-iodophenyl)-1-(1,3-thiazolidin-3...)
Show SMILES N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C12H15IN2OS/c13-10-3-1-9(2-4-10)7-11(14)12(16)15-5-6-17-8-15/h1-4,11H,5-8,14H2/t11-/m0/s1
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980 -34.3n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11126
PNG
((2S)-2-amino-3-(4-phenylphenyl)-1-(pyrrolidin-1-yl...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCCC1 |r|
Show InChI InChI=1S/C19H22N2O/c20-18(19(22)21-12-4-5-13-21)14-15-8-10-17(11-9-15)16-6-2-1-3-7-16/h1-3,6-11,18H,4-5,12-14,20H2/t18-/m0/s1
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1.16E+3 -33.9n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11137
PNG
((2S)-2-amino-3-(naphthalen-2-yl)-1-(1,3-thiazolidi...)
Show SMILES N[C@@H](Cc1ccc2ccccc2c1)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C16H18N2OS/c17-15(16(19)18-7-8-20-11-18)10-12-5-6-13-3-1-2-4-14(13)9-12/h1-6,9,15H,7-8,10-11,17H2/t15-/m0/s1
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8.90E+3 -28.8n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11127
PNG
((2S)-2-amino-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1CO |r|
Show InChI InChI=1S/C20H24N2O2/c21-19(20(24)22-12-4-7-18(22)14-23)13-15-8-10-17(11-9-15)16-5-2-1-3-6-16/h1-3,5-6,8-11,18-19,23H,4,7,12-14,21H2/t18-,19-/m0/s1
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>1.28E+4>-27.9n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11129
PNG
((2S)-2-amino-1-(2,2-dimethyl-1,3-oxazolidin-3-yl)-...)
Show SMILES CC1(C)OCCN1C(=O)[C@@H](N)Cc1ccc(cc1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H24N2O2/c1-20(2)22(12-13-24-20)19(23)18(21)14-15-8-10-17(11-9-15)16-6-4-3-5-7-16/h3-11,18H,12-14,21H2,1-2H3/t18-/m0/s1
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>1.28E+4>-27.9n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11139
PNG
((2S)-2-amino-3-(1H-indol-3-yl)-1-(1,3-thiazolidin-...)
Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C14H17N3OS/c15-12(14(18)17-5-6-19-9-17)7-10-8-16-13-4-2-1-3-11(10)13/h1-4,8,12,16H,5-7,9,15H2/t12-/m0/s1
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>1.28E+4>-27.9n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11138
PNG
((2S)-2-amino-3-(naphthalen-1-yl)-1-(1,3-thiazolidi...)
Show SMILES N[C@@H](Cc1cccc2ccccc12)C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C16H18N2OS/c17-15(16(19)18-8-9-20-11-18)10-13-6-3-5-12-4-1-2-7-14(12)13/h1-7,15H,8-11,17H2/t15-/m0/s1
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>1.28E+4>-27.9n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11128
PNG
((2S)-2-amino-1-[(2S)-2-[(benzyloxy)methyl]pyrrolid...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1COCc1ccccc1 |r|
Show InChI InChI=1S/C27H30N2O2/c28-26(18-21-13-15-24(16-14-21)23-10-5-2-6-11-23)27(30)29-17-7-12-25(29)20-31-19-22-8-3-1-4-9-22/h1-6,8-11,13-16,25-26H,7,12,17-20,28H2/t25-,26-/m0/s1
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>1.28E+4>-27.9n/an/an/an/an/a7.425



Johnson & Johnson Pharmaceutical



Assay Description
The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...


Bioorg Med Chem Lett 16: 123-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q2S180QJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50217358
PNG
(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)...)
Show SMILES CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H25N7O3/c1-32-27-15-20-21(24)25-16-26-22(20)29-11-13-30(14-12-29)23(31)28-17-7-9-19(10-8-17)33-18-5-3-2-4-6-18/h2-10,15-16H,11-14H2,1H3,(H,28,31)(H2,24,25,26)/b27-15+
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n/an/a 1n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


Bioorg Med Chem Lett 17: 4861-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.046
BindingDB Entry DOI: 10.7270/Q2T72H47
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50217367
PNG
(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)...)
Show SMILES CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C21H28N8O2/c1-31-25-14-18-19(22)23-15-24-20(18)28-10-12-29(13-11-28)21(30)26-16-4-6-17(7-5-16)27-8-2-3-9-27/h4-7,14-15H,2-3,8-13H2,1H3,(H,26,30)(H2,22,23,24)/b25-14+
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n/an/a 3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


Bioorg Med Chem Lett 17: 4861-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.046
BindingDB Entry DOI: 10.7270/Q2T72H47
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50217357
PNG
(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)...)
Show SMILES CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)N(C)C
Show InChI InChI=1S/C19H26N8O2/c1-25(2)15-6-4-14(5-7-15)24-19(28)27-10-8-26(9-11-27)18-16(12-23-29-3)17(20)21-13-22-18/h4-7,12-13H,8-11H2,1-3H3,(H,24,28)(H2,20,21,22)/b23-12+
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n/an/a 14n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


Bioorg Med Chem Lett 17: 4861-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.046
BindingDB Entry DOI: 10.7270/Q2T72H47
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50217366
PNG
(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)...)
Show SMILES CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)C(C)C
Show InChI InChI=1S/C20H27N7O2/c1-14(2)15-4-6-16(7-5-15)25-20(28)27-10-8-26(9-11-27)19-17(12-24-29-3)18(21)22-13-23-19/h4-7,12-14H,8-11H2,1-3H3,(H,25,28)(H2,21,22,23)/b24-12+
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n/an/a 15n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


Bioorg Med Chem Lett 17: 4861-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.046
BindingDB Entry DOI: 10.7270/Q2T72H47
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50217362
PNG
(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)...)
Show SMILES CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(OC2CCCC2)nc1
Show InChI InChI=1S/C21H28N8O3/c1-31-26-13-17-19(22)24-14-25-20(17)28-8-10-29(11-9-28)21(30)27-15-6-7-18(23-12-15)32-16-4-2-3-5-16/h6-7,12-14,16H,2-5,8-11H2,1H3,(H,27,30)(H2,22,24,25)/b26-13+
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n/an/a 18n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human FLT3


Bioorg Med Chem Lett 17: 4861-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.046
BindingDB Entry DOI: 10.7270/Q2T72H47
More data for this
Ligand-Target Pair
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