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Compile Data Set for Download or QSAR

Found 1180 hits with Last Name = 'beer' and Initial = 'ms'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139355
PNG
(2-(6-Phenylpyridin-2-ylthio)-N,N-dimethylethan-ami...)
Show SMILES CN(C)CCSc1cccc(n1)-c1ccccc1
Show InChI InChI=1S/C15H18N2S/c1-17(2)11-12-18-15-10-6-9-14(16-15)13-7-4-3-5-8-13/h3-10H,11-12H2,1-2H3
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0.600n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139351
PNG
(2-(6-cyclohexylpyridin-2-ylthio)-N,N-dimethylethan...)
Show SMILES CN(C)CCSc1cccc(n1)C1CCCCC1
Show InChI InChI=1S/C15H24N2S/c1-17(2)11-12-18-15-10-6-9-14(16-15)13-7-4-3-5-8-13/h6,9-10,13H,3-5,7-8,11-12H2,1-2H3
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0.700n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082406
PNG
(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)
Show SMILES O[C@H](COc1ccccc1F)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C25H26FNO3/c26-23-7-3-4-8-24(23)29-16-19(28)15-27-13-11-25(12-14-27)22-10-9-18-5-1-2-6-20(18)21(22)17-30-25/h1-10,19,28H,11-17H2/t19-/m0/s1
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1n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082405
PNG
(1-phenoxy-3-spiro[1,3-dihydrobenzo[e]isobenzofuran...)
Show SMILES O[C@H](COc1ccccc1)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C25H27NO3/c27-20(17-28-21-7-2-1-3-8-21)16-26-14-12-25(13-15-26)24-11-10-19-6-4-5-9-22(19)23(24)18-29-25/h1-11,20,27H,12-18H2/t20-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL




Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106269
PNG
((2-{2-[3-(3-Methoxy-benzyl)-[1,2,4]oxadiazol-5-yl]...)
Show SMILES COc1cccc(Cc2noc(n2)-c2[nH]c3ccccc3c2CCN(C)C)c1
Show InChI InChI=1S/C22H24N4O2/c1-26(2)12-11-18-17-9-4-5-10-19(17)23-21(18)22-24-20(25-28-22)14-15-7-6-8-16(13-15)27-3/h4-10,13,23H,11-12,14H2,1-3H3
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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139353
PNG
((2-tert-Butylsulfanyl-ethyl)-dimethyl-amine | CHEM...)
Show SMILES CN(C)CCSC(C)(C)C
Show InChI InChI=1S/C8H19NS/c1-8(2,3)10-7-6-9(4)5/h6-7H2,1-5H3
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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106249
PNG
(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Show SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-11-15-7-6-10-18-17(15)12-14-20(18)23(21,22)16-8-4-3-5-9-16/h3-10,12,14H,11,13H2,1-2H3
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1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082413
PNG
(1-(3-ethylphenoxy)-3-spiro[1,3-dihydrobenzo[e]isob...)
Show SMILES CCc1cccc(OC[C@@H](O)CN2CCC3(CC2)OCc2c3ccc3ccccc23)c1
Show InChI InChI=1S/C27H31NO3/c1-2-20-6-5-8-23(16-20)30-18-22(29)17-28-14-12-27(13-15-28)26-11-10-21-7-3-4-9-24(21)25(26)19-31-27/h3-11,16,22,29H,2,12-15,17-19H2,1H3/t22-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082408
PNG
(1-benzyloxy-3-spiro[1,3-dihydrobenzo[e]isobenzofur...)
Show SMILES OC(COCc1ccccc1)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C26H29NO3/c28-22(18-29-17-20-6-2-1-3-7-20)16-27-14-12-26(13-15-27)25-11-10-21-8-4-5-9-23(21)24(25)19-30-26/h1-11,22,28H,12-19H2
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2.20n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL




Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM34141
PNG
(CHEMBL76237 | MS-245)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22N2O3S/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17/h4-10,13-14H,11-12H2,1-3H3
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2.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082410
PNG
(4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...)
Show SMILES OC(COc1ccc(F)c2CCC(=O)c12)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C28H28FNO4/c29-24-8-10-26(27-21(24)6-9-25(27)32)33-16-19(31)15-30-13-11-28(12-14-30)23-7-5-18-3-1-2-4-20(18)22(23)17-34-28/h1-5,7-8,10,19,31H,6,9,11-17H2
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2.30n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL




Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106251
PNG
(2-(1-Benzenesulfonyl-1H-indol-4-yl)-ethylamine | C...)
Show SMILES NCCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O2S/c17-11-9-13-5-4-8-16-15(13)10-12-18(16)21(19,20)14-6-2-1-3-7-14/h1-8,10,12H,9,11,17H2
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2.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082411
PNG
(1-(5-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)
Show SMILES OC(COc1ccc(F)c2CCCOc12)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C28H30FNO4/c29-25-9-10-26(27-22(25)6-3-15-32-27)33-17-20(31)16-30-13-11-28(12-14-30)24-8-7-19-4-1-2-5-21(19)23(24)18-34-28/h1-2,4-5,7-10,20,31H,3,6,11-18H2
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2.80n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL




Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106250
PNG
(CHEMBL93868 | N,N-dimethyl-2-(1-(phenylsulfonyl)-1...)
Show SMILES CN(C)CCc1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-12-15-14-20(18-11-7-6-10-17(15)18)23(21,22)16-8-4-3-5-9-16/h3-11,14H,12-13H2,1-2H3
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2.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106246
PNG
(CHEMBL126340 | [1-Benzenesulfonyl-4-(2-dimethylami...)
Show SMILES CN(C)CCc1cccc2n(c(cc12)C(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H24N2O3S/c1-26(2)17-16-19-12-9-15-23-22(19)18-24(25(28)20-10-5-3-6-11-20)27(23)31(29,30)21-13-7-4-8-14-21/h3-15,18H,16-17H2,1-2H3
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3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50106249
PNG
(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Show SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-11-15-7-6-10-18-17(15)12-14-20(18)23(21,22)16-8-4-3-5-9-16/h3-10,12,14H,11,13H2,1-2H3
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3.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]-5-HT radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139361
PNG
(2-(6-Bromopyridin-2-ylthio)-N,N-dimethylethanamine...)
Show SMILES CN(C)CCSc1cccc(Br)n1
Show InChI InChI=1S/C9H13BrN2S/c1-12(2)6-7-13-9-5-3-4-8(10)11-9/h3-5H,6-7H2,1-2H3
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4.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50106251
PNG
(2-(1-Benzenesulfonyl-1H-indol-4-yl)-ethylamine | C...)
Show SMILES NCCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O2S/c17-11-9-13-5-4-8-16-15(13)10-12-18(16)21(19,20)14-6-2-1-3-7-14/h1-8,10,12H,9,11,17H2
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4.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]-5-HT as radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50106251
PNG
(2-(1-Benzenesulfonyl-1H-indol-4-yl)-ethylamine | C...)
Show SMILES NCCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O2S/c17-11-9-13-5-4-8-16-15(13)10-12-18(16)21(19,20)14-6-2-1-3-7-14/h1-8,10,12H,9,11,17H2
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4.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 2 receptor of rat cortical membrane using [3H]-DOB radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082407
PNG
(1-(6-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)
Show SMILES OC(COc1cc(F)cc2CCCOc12)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C28H30FNO4/c29-21-14-20-5-3-13-32-27(20)26(15-21)33-17-22(31)16-30-11-9-28(10-12-30)25-8-7-19-4-1-2-6-23(19)24(25)18-34-28/h1-2,4,6-8,14-15,22,31H,3,5,9-13,16-18H2
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5.5n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082415
PNG
(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)
Show SMILES O[C@@H](COc1ccccc1F)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C25H26FNO3/c26-23-7-3-4-8-24(23)29-16-19(28)15-27-13-11-25(12-14-27)22-10-9-18-5-1-2-6-20(18)21(22)17-30-25/h1-10,19,28H,11-17H2/t19-/m1/s1
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6n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50106251
PNG
(2-(1-Benzenesulfonyl-1H-indol-4-yl)-ethylamine | C...)
Show SMILES NCCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O2S/c17-11-9-13-5-4-8-16-15(13)10-12-18(16)21(19,20)14-6-2-1-3-7-14/h1-8,10,12H,9,11,17H2
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6.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1B receptor in CHO cells using [3H]-5-HT as radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50106246
PNG
(CHEMBL126340 | [1-Benzenesulfonyl-4-(2-dimethylami...)
Show SMILES CN(C)CCc1cccc2n(c(cc12)C(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H24N2O3S/c1-26(2)17-16-19-12-9-15-23-22(19)18-24(25(28)20-10-5-3-6-11-20)27(23)31(29,30)21-13-7-4-8-14-21/h3-15,18H,16-17H2,1-2H3
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6.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 2 receptor of rat cortical membrane using [3H]-DOB radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139354
PNG
(1-[6-(2-Dimethylamino-ethylsulfanyl)-pyridin-2-yl]...)
Show SMILES CN(C)CCSc1cccc(n1)C1(O)CCCCC1
Show InChI InChI=1S/C15H24N2OS/c1-17(2)11-12-19-14-8-6-7-13(16-14)15(18)9-4-3-5-10-15/h6-8,18H,3-5,9-12H2,1-2H3
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7.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106248
PNG
((4S,5S)-4-Dimethylamino-1-(toluene-4-sulfonyl)-1,3...)
Show SMILES CN(C)[C@H]1Cc2cn(c3cccc([C@@H]1O)c23)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C20H22N2O3S/c1-13-7-9-15(10-8-13)26(24,25)22-12-14-11-18(21(2)3)20(23)16-5-4-6-17(22)19(14)16/h4-10,12,18,20,23H,11H2,1-3H3/t18-,20-/m0/s1
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7.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106258
PNG
(CHEMBL127636 | {2-[1-(3-Chloro-benzenesulfonyl)-5-...)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O3S/c1-21(2)10-9-14-13-22(19-8-7-16(25-3)12-18(14)19)26(23,24)17-6-4-5-15(20)11-17/h4-8,11-13H,9-10H2,1-3H3
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7.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106255
PNG
(CHEMBL98404 | [3-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Show SMILES CN(C)CCCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22N2O2S/c1-20(2)14-7-9-16-8-6-12-19-18(16)13-15-21(19)24(22,23)17-10-4-3-5-11-17/h3-6,8,10-13,15H,7,9,14H2,1-2H3
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7.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106270
PNG
(CHEMBL339741 | {2-[5-Methoxy-1-(thiophene-2-sulfon...)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C17H20N2O3S2/c1-18(2)9-8-13-12-19(24(20,21)17-5-4-10-23-17)16-7-6-14(22-3)11-15(13)16/h4-7,10-12H,8-9H2,1-3H3
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8.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50082412
PNG
(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)
Show SMILES OC(CCc1ccccc1)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C26H29NO2/c28-22(12-10-20-6-2-1-3-7-20)18-27-16-14-26(15-17-27)25-13-11-21-8-4-5-9-23(21)24(25)19-29-26/h1-9,11,13,22,28H,10,12,14-19H2
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8.30n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50139351
PNG
(2-(6-cyclohexylpyridin-2-ylthio)-N,N-dimethylethan...)
Show SMILES CN(C)CCSc1cccc(n1)C1CCCCC1
Show InChI InChI=1S/C15H24N2S/c1-17(2)11-12-18-15-10-6-9-14(16-15)13-7-4-3-5-8-13/h6,9-10,13H,3-5,7-8,11-12H2,1-2H3
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8.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 1A receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in HeL...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50106249
PNG
(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Show SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-11-15-7-6-10-18-17(15)12-14-20(18)23(21,22)16-8-4-3-5-9-16/h3-10,12,14H,11,13H2,1-2H3
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9.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]-5-HT as radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50093054
PNG
(CHEMBL75010 | {2-[5-Methoxy-1-(naphthalene-2-sulfo...)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O3S/c1-24(2)13-12-19-16-25(23-11-9-20(28-3)15-22(19)23)29(26,27)21-10-8-17-6-4-5-7-18(17)14-21/h4-11,14-16H,12-13H2,1-3H3
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9.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50082412
PNG
(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)
Show SMILES OC(CCc1ccccc1)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C26H29NO2/c28-22(12-10-20-6-2-1-3-7-20)18-27-16-14-26(15-17-27)25-13-11-21-8-4-5-9-23(21)24(25)19-29-26/h1-9,11,13,22,28H,10,12,14-19H2
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10n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortex


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106263
PNG
(CHEMBL129614 | {2-[1-(2-Chloro-benzenesulfonyl)-5-...)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C19H21ClN2O3S/c1-21(2)11-10-14-13-22(18-9-8-15(25-3)12-16(14)18)26(23,24)19-7-5-4-6-17(19)20/h4-9,12-13H,10-11H2,1-3H3
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11n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50106249
PNG
(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Show SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-11-15-7-6-10-18-17(15)12-14-20(18)23(21,22)16-8-4-3-5-9-16/h3-10,12,14H,11,13H2,1-2H3
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11n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1B receptor in CHO cells using [3H]-5-HT as radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106267
PNG
(CHEMBL126374 | [2-(1-Benzenesulfonyl-5-methoxy-2-m...)
Show SMILES COc1ccc2n(c(C)c(CCN(C)C)c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H24N2O3S/c1-15-18(12-13-21(2)3)19-14-16(25-4)10-11-20(19)22(15)26(23,24)17-8-6-5-7-9-17/h5-11,14H,12-13H2,1-4H3
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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139357
PNG
(CHEMBL345803 | Dimethyl-[2-(4-phenyl-thiazol-2-yls...)
Show SMILES CN(C)CCSc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C13H16N2S2/c1-15(2)8-9-16-13-14-12(10-17-13)11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3
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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50139355
PNG
(2-(6-Phenylpyridin-2-ylthio)-N,N-dimethylethan-ami...)
Show SMILES CN(C)CCSc1cccc(n1)-c1ccccc1
Show InChI InChI=1S/C15H18N2S/c1-17(2)11-12-18-15-10-6-9-14(16-15)13-7-4-3-5-8-13/h3-10H,11-12H2,1-2H3
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16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 1A receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in HeL...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50093053
PNG
(CHEMBL72574 | {2-[1-(4-Chloro-benzenesulfonyl)-5-m...)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O3S/c1-21(2)11-10-14-13-22(19-9-6-16(25-3)12-18(14)19)26(23,24)17-7-4-15(20)5-8-17/h4-9,12-13H,10-11H2,1-3H3
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17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50139353
PNG
((2-tert-Butylsulfanyl-ethyl)-dimethyl-amine | CHEM...)
Show SMILES CN(C)CCSC(C)(C)C
Show InChI InChI=1S/C8H19NS/c1-8(2,3)10-7-6-9(4)5/h6-7H2,1-5H3
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17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 1A receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in HeL...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50106249
PNG
(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Show SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-11-15-7-6-10-18-17(15)12-14-20(18)23(21,22)16-8-4-3-5-9-16/h3-10,12,14H,11,13H2,1-2H3
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18n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 2 receptor of rat cortical membrane using [3H]-DOB radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106254
PNG
(1-Benzenesulfonyl-3-(2-dimethylamino-ethyl)-1H-ind...)
Show SMILES CN(C)CCc1cn(c2ccc(O)cc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O3S/c1-19(2)11-10-14-13-20(18-9-8-15(21)12-17(14)18)24(22,23)16-6-4-3-5-7-16/h3-9,12-13,21H,10-11H2,1-2H3
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19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106247
PNG
(3-(2-Dimethylamino-ethyl)-1H-indole-2-carboxylic a...)
Show SMILES CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C
Show InChI InChI=1S/C15H20N2O2/c1-4-19-15(18)14-12(9-10-17(2)3)11-7-5-6-8-13(11)16-14/h5-8,16H,4,9-10H2,1-3H3
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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139352
PNG
(CHEMBL161203 | [2-(4-tert-Butyl-thiazol-2-ylsulfan...)
Show SMILES CN(C)CCSc1nc(cs1)C(C)(C)C
Show InChI InChI=1S/C11H20N2S2/c1-11(2,3)9-8-15-10(12-9)14-7-6-13(4)5/h8H,6-7H2,1-5H3
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22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50106250
PNG
(CHEMBL93868 | N,N-dimethyl-2-(1-(phenylsulfonyl)-1...)
Show SMILES CN(C)CCc1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-12-15-14-20(18-11-7-6-10-17(15)18)23(21,22)16-8-4-3-5-9-16/h3-11,14H,12-13H2,1-2H3
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23n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D3 in HEK 293 cells using [3H]-spiperone radioligand


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50019443
PNG
(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)
Show SMILES CC(C)NCC(O)COc1cccc2[nH]ccc12
Show InChI InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
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24n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50106261
PNG
(CHEMBL316881 | [3-(2-Dimethylamino-ethyl)-5-methox...)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)C(=O)c1ccccc1
Show InChI InChI=1S/C20H22N2O2/c1-21(2)12-11-16-14-22(20(23)15-7-5-4-6-8-15)19-10-9-17(24-3)13-18(16)19/h4-10,13-14H,11-12H2,1-3H3
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25n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50093045
PNG
(CHEMBL76466 | {2-[5-Methoxy-1-(4-methoxy-benzenesu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)n1cc(CCN(C)C)c2cc(OC)ccc12
Show InChI InChI=1S/C20H24N2O4S/c1-21(2)12-11-15-14-22(20-10-7-17(26-4)13-19(15)20)27(23,24)18-8-5-16(25-3)6-9-18/h5-10,13-14H,11-12H2,1-4H3
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26n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.


J Med Chem 44: 3881-95 (2001)


BindingDB Entry DOI: 10.7270/Q2T72GRW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50139356
PNG
(CHEMBL350166 | Dimethyl-[2-(4-pyridin-4-yl-thiazol...)
Show SMILES CN(C)CCSc1nc(cs1)-c1ccncc1
Show InChI InChI=1S/C12H15N3S2/c1-15(2)7-8-16-12-14-11(9-17-12)10-3-5-13-6-4-10/h3-6,9H,7-8H2,1-2H3
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27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...


Bioorg Med Chem Lett 14: 677-80 (2004)


BindingDB Entry DOI: 10.7270/Q2CJ8CWS
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50082414
PNG
(1'-(4-phenylbutyl)spiro[1,3-dihydrobenzo[e]isobenz...)
Show SMILES C(CCc1ccccc1)CN1CCC2(CC1)OCc1c2ccc2ccccc12
Show InChI InChI=1S/C26H29NO/c1-2-8-21(9-3-1)10-6-7-17-27-18-15-26(16-19-27)25-14-13-22-11-4-5-12-23(22)24(25)20-28-26/h1-5,8-9,11-14H,6-7,10,15-20H2
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28n/an/an/an/an/an/an/an/a



Merck

Curated by ChEMBL


Assay Description
Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortex


Bioorg Med Chem Lett 9: 3243-8 (1999)


BindingDB Entry DOI: 10.7270/Q2W37WVB
More data for this
Ligand-Target Pair
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