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Compile Data Set for Download or QSAR

Found 898 hits with Last Name = 'berdini' and Initial = 'v'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LDL-associated phospholipase A2


(Homo sapiens (Human))
BDBM50125265
PNG
(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1
Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3
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n/an/a 0.0350n/an/an/an/an/an/a



Astex Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate addition


J Med Chem 59: 10738-10749 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01427
BindingDB Entry DOI: 10.7270/Q27946ND
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
LDL-associated phospholipase A2


(Homo sapiens (Human))
BDBM50125265
PNG
(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1
Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3
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n/an/a 0.0490n/an/an/an/an/an/a



Astex Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrate


J Med Chem 59: 10738-10749 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01427
BindingDB Entry DOI: 10.7270/Q27946ND
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
LDL-associated phospholipase A2


(Homo sapiens (Human))
BDBM50125265
PNG
(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1
Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3
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n/an/a 0.0490n/an/an/an/an/an/a



Astex Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assay


J Med Chem 59: 5356-67 (2016)


BindingDB Entry DOI: 10.7270/Q2Z60R0G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128502
PNG
(US8796244, 81)
Show SMILES CC(C)(CO)Nc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N7O2/c1-23(2,14-35)31-20-7-6-18(32-33-20)15-8-9-34-19(12-28-21(34)11-15)16-4-3-5-17(10-16)30-22(36)29-13-24(25,26)27/h3-12,35H,13-14H2,1-2H3,(H,31,33)(H2,29,30,36)
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n/an/a 0.447n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128624
PNG
(US8796244, 213)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nccc(n1)-n1ccnc1
Show InChI InChI=1S/C23H17F3N8O/c24-23(25,26)13-30-22(35)31-17-3-1-2-15(10-17)18-12-29-20-11-16(5-8-34(18)20)21-28-6-4-19(32-21)33-9-7-27-14-33/h1-12,14H,13H2,(H2,30,31,35)
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n/an/a 0.460n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128551
PNG
(US8796244, 133)
Show SMILES OC1CCCN(C1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N7O2/c26-25(27,28)15-30-24(37)31-18-4-1-3-17(11-18)21-13-29-23-12-16(8-10-35(21)23)20-6-7-22(33-32-20)34-9-2-5-19(36)14-34/h1,3-4,6-8,10-13,19,36H,2,5,9,14-15H2,(H2,30,31,37)
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n/an/a 0.484n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139913
PNG
(US8895745, 375)
Show SMILES Cn1cnc(c1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N6O/c1-28-10-16(26-12-28)13-5-6-29-17(9-24-18(29)8-13)14-3-2-4-15(7-14)27-19(30)25-11-20(21,22)23/h2-10,12H,11H2,1H3,(H2,25,27,30)
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n/an/a 0.490n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128659
PNG
(US8796244, 250)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nnc(NC2CC2)s1
Show InChI InChI=1S/C21H18F3N7OS/c22-21(23,24)11-26-19(32)27-15-3-1-2-12(8-15)16-10-25-17-9-13(6-7-31(16)17)18-29-30-20(33-18)28-14-4-5-14/h1-3,6-10,14H,4-5,11H2,(H,28,30)(H2,26,27,32)
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n/an/a 0.5n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128516
PNG
(US8796244, 95)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCNC(=O)C1
Show InChI InChI=1S/C24H21F3N8O2/c25-24(26,27)14-30-23(37)31-17-3-1-2-16(10-17)19-12-29-21-11-15(6-8-35(19)21)18-4-5-20(33-32-18)34-9-7-28-22(36)13-34/h1-6,8,10-12H,7,9,13-14H2,(H,28,36)(H2,30,31,37)
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n/an/a 0.530n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128496
PNG
(US8796244, 75)
Show SMILES NC1CCN(CC1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H25F3N8O/c26-25(27,28)15-31-24(37)32-19-3-1-2-17(12-19)21-14-30-23-13-16(6-11-36(21)23)20-4-5-22(34-33-20)35-9-7-18(29)8-10-35/h1-6,11-14,18H,7-10,15,29H2,(H2,31,32,37)
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n/an/a 0.535n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128668
PNG
(US8796244, 261)
Show SMILES Nc1nnc(s1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C18H14F3N7OS/c19-18(20,21)9-24-17(29)25-12-3-1-2-10(6-12)13-8-23-14-7-11(4-5-28(13)14)15-26-27-16(22)30-15/h1-8H,9H2,(H2,22,27)(H2,24,25,29)
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n/an/a 0.540n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128468
PNG
(US8796244, 47)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCOC1
Show InChI InChI=1S/C23H21F3N6O2/c24-23(25,26)14-28-22(33)30-18-3-1-2-16(8-18)20-11-27-21-9-15(4-6-31(20)21)17-10-29-32(12-17)19-5-7-34-13-19/h1-4,6,8-12,19H,5,7,13-14H2,(H2,28,30,33)
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n/an/a 0.542n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128427
PNG
(US8796244, 6)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N7O/c1-33-8-6-21(7-9-33)35-15-19(13-31-35)17-5-10-34-22(14-29-23(34)12-17)18-3-2-4-20(11-18)32-24(36)30-16-25(26,27)28/h2-5,10-15,21H,6-9,16H2,1H3,(H2,30,32,36)
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n/an/a 0.545n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128428
PNG
(US8796244, 7)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCCCC1
Show InChI InChI=1S/C25H24F3N7O/c26-25(27,28)16-30-24(36)31-19-6-4-5-18(13-19)21-15-29-23-14-17(9-12-35(21)23)20-7-8-22(33-32-20)34-10-2-1-3-11-34/h4-9,12-15H,1-3,10-11,16H2,(H2,30,31,36)
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n/an/a 0.550n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128561
PNG
(US8796244, 145)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H26F3N7O2/c1-18(38)35-9-11-36(12-10-35)24-6-5-21(15-31-24)19-7-8-37-23(16-32-25(37)14-19)20-3-2-4-22(13-20)34-26(39)33-17-27(28,29)30/h2-8,13-16H,9-12,17H2,1H3,(H2,33,34,39)
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n/an/a 0.560n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128488
PNG
(US8796244, 67)
Show SMILES OCCNc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N7O2/c23-22(24,25)13-28-21(34)29-16-3-1-2-15(10-16)18-12-27-20-11-14(6-8-32(18)20)17-4-5-19(31-30-17)26-7-9-33/h1-6,8,10-12,33H,7,9,13H2,(H,26,31)(H2,28,29,34)
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n/an/a 0.569n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128425
PNG
(US8796244, 4)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H24F3N7O/c25-24(26,27)15-30-23(35)32-19-3-1-2-17(10-19)21-13-29-22-11-16(6-9-33(21)22)18-12-31-34(14-18)20-4-7-28-8-5-20/h1-3,6,9-14,20,28H,4-5,7-8,15H2,(H2,30,32,35)
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n/an/a 0.570n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128465
PNG
(US8796244, 44)
Show SMILES CCN1CCC(C1)N=CC(C=N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 |w:7.7|
Show InChI InChI=1S/C25H28F3N7O/c1-2-34-8-7-21(15-34)30-13-19(12-29)17-6-9-35-22(14-31-23(35)11-17)18-4-3-5-20(10-18)33-24(36)32-16-25(26,27)28/h3-6,9-14,19,21,29H,2,7-8,15-16H2,1H3,(H2,32,33,36)
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n/an/a 0.582n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128466
PNG
(US8796244, 45)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCNC1
Show InChI InChI=1S/C23H22F3N7O/c24-23(25,26)14-29-22(34)31-18-3-1-2-16(8-18)20-12-28-21-9-15(5-7-32(20)21)17-10-30-33(13-17)19-4-6-27-11-19/h1-3,5,7-10,12-13,19,27H,4,6,11,14H2,(H2,29,31,34)
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n/an/a 0.603n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128534
PNG
(US8796244, 113)
Show SMILES CN(C)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N7O/c1-31(2)19-7-6-17(29-30-19)14-8-9-32-18(12-26-20(32)11-14)15-4-3-5-16(10-15)28-21(33)27-13-22(23,24)25/h3-12H,13H2,1-2H3,(H2,27,28,33)
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n/an/a 0.610n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128459
PNG
(US8796244, 38)
Show SMILES CN1CCCC(C1)N=CC(C=N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 |w:7.7|
Show InChI InChI=1S/C25H28F3N7O/c1-34-8-3-6-21(15-34)30-13-19(12-29)17-7-9-35-22(14-31-23(35)11-17)18-4-2-5-20(10-18)33-24(36)32-16-25(26,27)28/h2,4-5,7,9-14,19,21,29H,3,6,8,15-16H2,1H3,(H2,32,33,36)
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n/an/a 0.610n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128461
PNG
(US8796244, 40)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCCNC1
Show InChI InChI=1S/C24H24F3N7O/c25-24(26,27)15-30-23(35)32-19-4-1-3-17(9-19)21-13-29-22-10-16(6-8-33(21)22)18-11-31-34(14-18)20-5-2-7-28-12-20/h1,3-4,6,8-11,13-14,20,28H,2,5,7,12,15H2,(H2,30,32,35)
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n/an/a 0.612n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128453
PNG
(US8796244, 32)
Show SMILES CC(C)N1CC(C1)N=CC(C=N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 |w:7.7|
Show InChI InChI=1S/C25H28F3N7O/c1-16(2)34-13-21(14-34)30-11-19(10-29)17-6-7-35-22(12-31-23(35)9-17)18-4-3-5-20(8-18)33-24(36)32-15-25(26,27)28/h3-12,16,19,21,29H,13-15H2,1-2H3,(H2,32,33,36)
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n/an/a 0.613n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128436
PNG
(US8796244, 15)
Show SMILES NC(=CCC(=N)N1CCOCC1)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 |w:2.2|
Show InChI InChI=1S/C24H26F3N7O2/c25-24(26,27)15-31-23(35)32-18-3-1-2-17(12-18)20-14-30-22-13-16(6-7-34(20)22)19(28)4-5-21(29)33-8-10-36-11-9-33/h1-4,6-7,12-14,29H,5,8-11,15,28H2,(H2,31,32,35)
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n/an/a 0.640n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128725
PNG
(US8796244, 319)
Show SMILES COCCc1nnc(s1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N6O2S/c1-32-8-6-18-28-29-19(33-18)14-5-7-30-16(11-25-17(30)10-14)13-3-2-4-15(9-13)27-20(31)26-12-21(22,23)24/h2-5,7,9-11H,6,8,12H2,1H3,(H2,26,27,31)
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n/an/a 0.643n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128474
PNG
(US8796244, 53)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nc2CCNCc2s1
Show InChI InChI=1S/C22H19F3N6OS/c23-22(24,25)12-28-21(32)29-15-3-1-2-13(8-15)17-10-27-19-9-14(5-7-31(17)19)20-30-16-4-6-26-11-18(16)33-20/h1-3,5,7-10,26H,4,6,11-12H2,(H2,28,29,32)
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n/an/a 0.675n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128443
PNG
(US8796244, 22)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nnc(CCN2CCCCC2)s1
Show InChI InChI=1S/C25H26F3N7OS/c26-25(27,28)16-30-24(36)31-19-6-4-5-17(13-19)20-15-29-21-14-18(7-12-35(20)21)23-33-32-22(37-23)8-11-34-9-2-1-3-10-34/h4-7,12-15H,1-3,8-11,16H2,(H2,30,31,36)
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n/an/a 0.704n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128543
PNG
(US8796244, 122)
Show SMILES OCCc1ccc(nc1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N5O2/c24-23(25,26)14-29-22(33)30-18-3-1-2-17(10-18)20-13-28-21-11-16(6-8-31(20)21)19-5-4-15(7-9-32)12-27-19/h1-6,8,10-13,32H,7,9,14H2,(H2,29,30,33)
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n/an/a 0.704n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139918
PNG
(US8895745, 401)
Show SMILES OCCn1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N6O2/c22-21(23,24)13-26-20(32)28-17-3-1-2-15(8-17)18-11-25-19-9-14(4-5-30(18)19)16-10-27-29(12-16)6-7-31/h1-5,8-12,31H,6-7,13H2,(H2,26,28,32)
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n/an/a 0.704n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128550
PNG
(US8796244, 132)
Show SMILES CNc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C21H18F3N7O/c1-25-18-6-5-16(29-30-18)13-7-8-31-17(11-26-19(31)10-13)14-3-2-4-15(9-14)28-20(32)27-12-21(22,23)24/h2-11H,12H2,1H3,(H,25,30)(H2,27,28,32)
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n/an/a 0.710n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128503
PNG
(US8796244, 82)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCC1
Show InChI InChI=1S/C23H20F3N7O/c24-23(25,26)14-28-22(34)29-17-4-1-3-16(11-17)19-13-27-21-12-15(7-10-33(19)21)18-5-6-20(31-30-18)32-8-2-9-32/h1,3-7,10-13H,2,8-9,14H2,(H2,28,29,34)
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n/an/a 0.715n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128497
PNG
(US8796244, 76)
Show SMILES CN1CCC(CC1)Nc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H27F3N8O/c1-36-10-8-19(9-11-36)32-23-6-5-21(34-35-23)17-7-12-37-22(15-30-24(37)14-17)18-3-2-4-20(13-18)33-25(38)31-16-26(27,28)29/h2-7,12-15,19H,8-11,16H2,1H3,(H,32,35)(H2,31,33,38)
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n/an/a 0.730n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128491
PNG
(US8796244, 70)
Show SMILES CN(C)C(=O)C(C)(C)N=CC(C=N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 |w:8.7|
Show InChI InChI=1S/C25H28F3N7O2/c1-24(2,22(36)34(3)4)32-13-18(12-29)16-8-9-35-20(14-30-21(35)11-16)17-6-5-7-19(10-17)33-23(37)31-15-25(26,27)28/h5-14,18,29H,15H2,1-4H3,(H2,31,33,37)
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n/an/a 0.740n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139909
PNG
(US8895745, 310)
Show SMILES Cc1nnc(s1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C19H15F3N6OS/c1-11-26-27-17(30-11)13-5-6-28-15(9-23-16(28)8-13)12-3-2-4-14(7-12)25-18(29)24-10-19(20,21)22/h2-9H,10H2,1H3,(H2,24,25,29)
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n/an/a 0.780n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128545
PNG
(US8796244, 124)
Show SMILES Nc1ccc(nc1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C21H17F3N6O/c22-21(23,24)12-28-20(31)29-16-3-1-2-14(8-16)18-11-27-19-9-13(6-7-30(18)19)17-5-4-15(25)10-26-17/h1-11H,12,25H2,(H2,28,29,31)
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n/an/a 0.789n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139914
PNG
(US8895745, 378)
Show SMILES Cc1c(nnn1C)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C20H18F3N7O/c1-12-18(27-28-29(12)2)14-6-7-30-16(10-24-17(30)9-14)13-4-3-5-15(8-13)26-19(31)25-11-20(21,22)23/h3-10H,11H2,1-2H3,(H2,25,26,31)
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n/an/a 0.790n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128458
PNG
(US8796244, 37)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CNC1
Show InChI InChI=1S/C22H20F3N7O/c23-22(24,25)13-28-21(33)30-17-3-1-2-15(6-17)19-11-27-20-7-14(4-5-31(19)20)16-8-29-32(12-16)18-9-26-10-18/h1-8,11-12,18,26H,9-10,13H2,(H2,28,30,33)
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n/an/a 0.807n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128457
PNG
(US8796244, 36)
Show SMILES CN(C)C1CCN(CC1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H29F3N8O/c1-36(2)21-9-11-37(12-10-21)24-7-6-22(34-35-24)18-8-13-38-23(16-31-25(38)15-18)19-4-3-5-20(14-19)33-26(39)32-17-27(28,29)30/h3-8,13-16,21H,9-12,17H2,1-2H3,(H2,32,33,39)
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n/an/a 0.820n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128422
PNG
(US8796244, 1)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nnc(s1)C1CCCO1
Show InChI InChI=1S/C22H19F3N6O2S/c23-22(24,25)12-27-21(32)28-15-4-1-3-13(9-15)16-11-26-18-10-14(6-7-31(16)18)19-29-30-20(34-19)17-5-2-8-33-17/h1,3-4,6-7,9-11,17H,2,5,8,12H2,(H2,27,28,32)
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n/an/a 0.830n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128653
PNG
(US8796244, 242)
Show SMILES CC(C)c1cnc(N)nc1-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N7O/c1-13(2)17-10-29-21(27)32-20(17)15-6-7-33-18(11-28-19(33)9-15)14-4-3-5-16(8-14)31-22(34)30-12-23(24,25)26/h3-11,13H,12H2,1-2H3,(H2,27,29,32)(H2,30,31,34)
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n/an/a 0.830n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128512
PNG
(US8796244, 91)
Show SMILES Cc1ccc(nc1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H18F3N5O/c1-14-5-6-18(26-11-14)15-7-8-30-19(12-27-20(30)10-15)16-3-2-4-17(9-16)29-21(31)28-13-22(23,24)25/h2-12H,13H2,1H3,(H2,28,29,31)
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n/an/a 0.840n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128423
PNG
(US8796244, 2)
Show SMILES CCOC(=O)C(C)(C)n1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H25F3N6O3/c1-4-37-22(35)24(2,3)34-14-18(12-31-34)16-8-9-33-20(13-29-21(33)11-16)17-6-5-7-19(10-17)32-23(36)30-15-25(26,27)28/h5-14H,4,15H2,1-3H3,(H2,30,32,36)
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n/an/a 0.850n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128646
PNG
(US8796244, 235)
Show SMILES CCNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ncc(c(N)n1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N7O/c1-2-26-20(32)29-14-5-3-4-12(8-14)16-11-27-17-9-13(6-7-31(16)17)19-28-10-15(18(25)30-19)21(22,23)24/h3-11H,2H2,1H3,(H2,25,28,30)(H2,26,29,32)
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n/an/a 0.880n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128501
PNG
(US8796244, 80)
Show SMILES COCCNc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N7O2/c1-35-10-8-27-20-6-5-18(31-32-20)15-7-9-33-19(13-28-21(33)12-15)16-3-2-4-17(11-16)30-22(34)29-14-23(24,25)26/h2-7,9,11-13H,8,10,14H2,1H3,(H,27,32)(H2,29,30,34)
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n/an/a 0.890n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128532
PNG
(US8796244, 111)
Show SMILES OCCc1ccc(cc1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N4O2/c25-24(26,27)15-29-23(33)30-20-3-1-2-19(12-20)21-14-28-22-13-18(8-10-31(21)22)17-6-4-16(5-7-17)9-11-32/h1-8,10,12-14,32H,9,11,15H2,(H2,29,30,33)
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n/an/a 0.890n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128566
PNG
(US8796244, 152)
Show SMILES FC(F)(F)CNC(=O)Nc1cncc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C23H23F3N8O/c24-23(25,26)14-30-22(35)32-18-7-16(9-28-11-18)20-12-29-21-8-15(3-6-33(20)21)17-10-31-34(13-17)19-1-4-27-5-2-19/h3,6-13,19,27H,1-2,4-5,14H2,(H2,30,32,35)
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n/an/a 0.930n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128513
PNG
(US8796244, 92)
Show SMILES OCc1ccc(nc1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H18F3N5O2/c23-22(24,25)13-28-21(32)29-17-3-1-2-16(8-17)19-11-27-20-9-15(6-7-30(19)20)18-5-4-14(12-31)10-26-18/h1-11,31H,12-13H2,(H2,28,29,32)
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n/an/a 0.940n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128658
PNG
(US8796244, 247)
Show SMILES CC(C)Oc1cc(NC(=O)NCC(F)(F)F)cc(c1)-c1cnc2cc(ccn12)-c1nn2cc(C)nc2s1
Show InChI InChI=1S/C24H22F3N7O2S/c1-13(2)36-18-7-16(6-17(9-18)31-22(35)29-12-24(25,26)27)19-10-28-20-8-15(4-5-33(19)20)21-32-34-11-14(3)30-23(34)37-21/h4-11,13H,12H2,1-3H3,(H2,29,31,35)
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n/an/a 0.960n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128695
PNG
(US8796244, 289)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nnc(Nc2cccnc2)s1
Show InChI InChI=1S/C23H17F3N8OS/c24-23(25,26)13-29-21(35)30-16-4-1-3-14(9-16)18-12-28-19-10-15(6-8-34(18)19)20-32-33-22(36-20)31-17-5-2-7-27-11-17/h1-12H,13H2,(H,31,33)(H2,29,30,35)
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n/an/a 0.990n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128616
PNG
(US8796244, 204)
Show SMILES COc1ccc(nc1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H18F3N5O2/c1-32-17-5-6-18(26-11-17)14-7-8-30-19(12-27-20(30)10-14)15-3-2-4-16(9-15)29-21(31)28-13-22(23,24)25/h2-12H,13H2,1H3,(H2,28,29,31)
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n/an/a 0.990n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
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