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Compile Data Set for Download or QSAR

Found 470 hits with Last Name = 'blanco aparicio' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161942
PNG
(US9682991, 5)
Show SMILES CN(C)C1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O2/c1-29(2)15-7-9-31(10-8-15)20-17-18(33-12-11-30(17)3)21-27-26-19(32(21)28-20)14-5-4-6-16(13-14)34-22(23,24)25/h4-6,13,15H,7-12H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161946
PNG
(US9682991, 7)
Show SMILES CN1CCOc2c1c(NCC1CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H19F3N6O2/c1-27-7-8-29-15-14(27)16(23-10-11-5-6-11)26-28-17(24-25-18(15)28)12-3-2-4-13(9-12)30-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,23,26)
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n/an/a 25n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251623
PNG
(US9453031, 46)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C(C)(C)O)c2cc[nH]c2c1 |r|
Show InChI InChI=1/C21H24N4O4/c1-21(2,26)18-17-20(25-6-7-28-10-12(25)11-29-17)24-19(23-18)15-8-13(27-3)9-16-14(15)4-5-22-16/h4-5,8-9,12,22,26H,6-7,10-11H2,1-3H3/t12-/s2
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n/an/a 38n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251621
PNG
(US9453031, 44)
Show SMILES CC(C)(O)c1nc(nc2N3CCOC[C@H]3COc12)-c1cccc2[nH]ccc12 |r|
Show InChI InChI=1/C20H22N4O3/c1-20(2,25)17-16-19(24-8-9-26-10-12(24)11-27-16)23-18(22-17)14-4-3-5-15-13(14)6-7-21-15/h3-7,12,21,25H,8-11H2,1-2H3/t12-/s2
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n/an/a 44n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251635
PNG
(US9453031, 72)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C(C)(C)S(C)(=O)=O)c2cc[nH]c2c1 |r|
Show InChI InChI=1/C22H26N4O5S/c1-22(2,32(4,27)28)19-18-21(26-7-8-30-11-13(26)12-31-18)25-20(24-19)16-9-14(29-3)10-17-15(16)5-6-23-17/h5-6,9-10,13,23H,7-8,11-12H2,1-4H3/t13-/s2
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n/an/a 45.3n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251641
PNG
(US9453031, 78)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C2(CCC2)S(C)(=O)=O)c2cc[nH]c2c1 |r|
Show InChI InChI=1/C23H26N4O5S/c1-30-15-10-17(16-4-7-24-18(16)11-15)21-25-20(23(5-3-6-23)33(2,28)29)19-22(26-21)27-8-9-31-12-14(27)13-32-19/h4,7,10-11,14,24H,3,5-6,8-9,12-13H2,1-2H3/t14-/s2
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n/an/a 47n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161950
PNG
(US9682991, 9)
Show SMILES CN1CCOc2c1c(NCc1ccc(F)cc1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H18F4N6O2/c1-31-9-10-33-18-17(31)19(27-12-13-5-7-15(23)8-6-13)30-32-20(28-29-21(18)32)14-3-2-4-16(11-14)34-22(24,25)26/h2-8,11H,9-10,12H2,1H3,(H,27,30)
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n/an/a 52n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251622
PNG
(US9453031, 45)
Show SMILES CC(C)(O)c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(F)cc2[nH]ccc12 |r|
Show InChI InChI=1/C20H21FN4O3/c1-20(2,26)17-16-19(25-5-6-27-9-12(25)10-28-16)24-18(23-17)14-7-11(21)8-15-13(14)3-4-22-15/h3-4,7-8,12,22,26H,5-6,9-10H2,1-2H3/t12-/s2
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n/an/a 53n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251652
PNG
(US9453031, 103)
Show SMILES Cc1cc2c(cccc2[nH]1)-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O |r|
Show InChI InChI=1/C22H26N4O4S/c1-13-10-16-15(6-5-7-17(16)23-13)20-24-19(22(2,3)31(4,27)28)18-21(25-20)26-8-9-29-11-14(26)12-30-18/h5-7,10,14,23H,8-9,11-12H2,1-4H3/t14-/s2
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n/an/a 58n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251638
PNG
(US9453031, 75)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C2(CC2)S(C)(=O)=O)c2cc[nH]c2c1 |r|
Show InChI InChI=1/C22H24N4O5S/c1-29-14-9-16(15-3-6-23-17(15)10-14)20-24-19(22(4-5-22)32(2,27)28)18-21(25-20)26-7-8-30-11-13(26)12-31-18/h3,6,9-10,13,23H,4-5,7-8,11-12H2,1-2H3/t13-/s2
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n/an/a 93n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251634
PNG
(US9453031, 71)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(F)cc2[nH]ccc12)S(C)(=O)=O |r|
Show InChI InChI=1/C21H23FN4O4S/c1-21(2,31(3,27)28)18-17-20(26-6-7-29-10-13(26)11-30-17)25-19(24-18)15-8-12(22)9-16-14(15)4-5-23-16/h4-5,8-9,13,23H,6-7,10-11H2,1-3H3/t13-/s2
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n/an/a 99.3n/an/an/an/a7.525



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161985
PNG
(US9682991, 34)
Show SMILES CN(C)c1cccc(c1)-c1nnc2c3OCCN(C)c3c(NCC3CCN(C)CC3)nn12
Show InChI InChI=1S/C23H32N8O/c1-28(2)18-7-5-6-17(14-18)22-25-26-23-20-19(30(4)12-13-32-20)21(27-31(22)23)24-15-16-8-10-29(3)11-9-16/h5-7,14,16H,8-13,15H2,1-4H3,(H,24,27)
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
DNA-dependent protein kinase


(Homo sapiens (Human))
BDBM251651
PNG
(US9453031, 102)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)-c1ccc(F)c2[nH]ccc12)S(C)(=O)=O |r|
Show InChI InChI=1/C21H23FN4O4S/c1-21(2,31(3,27)28)18-17-20(26-8-9-29-10-12(26)11-30-17)25-19(24-18)14-4-5-15(22)16-13(14)6-7-23-16/h4-7,12,23H,8-11H2,1-3H3/t12-/s2
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n/an/a 100n/an/an/an/a7.537



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...


US Patent US9453031 (2016)


BindingDB Entry DOI: 10.7270/Q27H1HH8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161938
PNG
(US9682991, 2)
Show SMILES CN1CCC(CC1)Nc1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-8-6-14(7-9-29)25-18-16-17(32-11-10-30(16)2)20-27-26-19(31(20)28-18)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162014
PNG
(US9682991, 70)
Show SMILES CN1CCOc2c1c(N[C@@H]1CC[C@H](N)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wU:9.9,12.13,(-6.57,2.69,;-5.24,3.47,;-5.24,5,;-3.91,5.78,;-2.57,5,;-2.57,3.47,;-3.91,2.69,;-3.91,1.15,;-5.24,.38,;-5.24,-1.15,;-6.57,-1.93,;-6.57,-3.47,;-5.24,-4.23,;-5.24,-5.78,;-3.91,-3.47,;-3.91,-1.93,;-2.57,.38,;-1.24,1.15,;.23,.68,;1.13,1.93,;.23,3.17,;-1.24,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.86,-3.34,;2.11,-1.21,)|
Show InChI InChI=1/C21H24F3N7O2/c1-30-9-10-32-17-16(30)18(26-14-7-5-13(25)6-8-14)29-31-19(27-28-20(17)31)12-3-2-4-15(11-12)33-21(22,23)24/h2-4,11,13-14H,5-10,25H2,1H3,(H,26,29)/t13-,14+
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162015
PNG
(US9682991, 71)
Show SMILES CN1CCOc2c1c(N[C@H]1CC[C@H](N)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wU:9.9,wD:12.13,(-6.57,2.69,;-5.24,3.47,;-5.24,5,;-3.91,5.78,;-2.57,5,;-2.57,3.47,;-3.91,2.69,;-3.91,1.15,;-5.24,.38,;-5.24,-1.15,;-3.91,-1.93,;-3.91,-3.47,;-5.24,-4.23,;-5.24,-5.78,;-6.57,-3.47,;-6.57,-1.93,;-2.57,.38,;-1.24,1.15,;.23,.68,;1.13,1.93,;.23,3.17,;-1.24,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.86,-3.34,;2.11,-1.21,)|
Show InChI InChI=1/C21H24F3N7O2/c1-30-9-10-32-17-16(30)18(26-14-7-5-13(25)6-8-14)29-31-19(27-28-20(17)31)12-3-2-4-15(11-12)33-21(22,23)24/h2-4,11,13-14H,5-10,25H2,1H3,(H,26,29)/t13-,14-
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162017
PNG
(US9682991, 73)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCC(C)(C)N(C)c23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C24H30F3N7O2/c1-23(2)14-35-19-18(33(23)4)20(28-13-15-8-10-32(3)11-9-15)31-34-21(29-30-22(19)34)16-6-5-7-17(12-16)36-24(25,26)27/h5-7,12,15H,8-11,13-14H2,1-4H3,(H,28,31)
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162025
PNG
(US9682991, 81)
Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12
Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-29-21(25-26-22(19)29)15-5-9-17(30-2)10-6-15/h3-10H,11-13H2,1-2H3,(H,24,27)
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162029
PNG
(US9682991, 85)
Show SMILES CC(C)NCC1CCN(CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H30F3N7O2/c1-15(2)28-14-16-7-9-33(10-8-16)22-19-20(35-12-11-32(19)3)23-30-29-21(34(23)31-22)17-5-4-6-18(13-17)36-24(25,26)27/h4-6,13,15-16,28H,7-12,14H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162031
PNG
(US9682991, 87)
Show SMILES CC(C)NC1CC2(C1)CCN(CC2)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H32F3N7O2/c1-16(2)30-18-14-25(15-18)7-9-35(10-8-25)23-20-21(37-12-11-34(20)3)24-32-31-22(36(24)33-23)17-5-4-6-19(13-17)38-26(27,28)29/h4-6,13,16,18,30H,7-12,14-15H2,1-3H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162032
PNG
(US9682991, 88)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC3CC3)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H30F3N7O2/c1-33-11-12-36-21-20(33)22(29-14-16-7-9-34(10-8-16)15-17-5-6-17)32-35-23(30-31-24(21)35)18-3-2-4-19(13-18)37-25(26,27)28/h2-4,13,16-17H,5-12,14-15H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162037
PNG
(US9682991, 93)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC1)C(C)=O)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O3/c1-14(34)32-8-6-15(7-9-32)13-27-20-18-19(35-11-10-31(18)2)22-29-28-21(33(22)30-20)16-4-3-5-17(12-16)36-23(24,25)26/h3-5,12,15H,6-11,13H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM162037
PNG
(US9682991, 93)
Show SMILES CN1CCOc2c1c(NCC1CCN(CC1)C(C)=O)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O3/c1-14(34)32-8-6-15(7-9-32)13-27-20-18-19(35-11-10-31(18)2)22-29-28-21(33(22)30-20)16-4-3-5-17(12-16)36-23(24,25)26/h3-5,12,15H,6-11,13H2,1-2H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162038
PNG
(US9682991, 94)
Show SMILES CN1CCN(C)c2c1c(NCc1ccc(F)cc1)nn1c(nnc21)-c1ccc(O)cc1
Show InChI InChI=1S/C22H22FN7O/c1-28-11-12-29(2)19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-30-21(25-26-22(19)30)15-5-9-17(31)10-6-15/h3-10,31H,11-13H2,1-2H3,(H,24,27)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162043
PNG
(US9682991, 97)
Show SMILES CN(C1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-28-8-11-32-17-16(28)19(29(2)14-6-9-31-10-7-14)27-30-18(25-26-20(17)30)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM162043
PNG
(US9682991, 97)
Show SMILES CN(C1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-28-8-11-32-17-16(28)19(29(2)14-6-9-31-10-7-14)27-30-18(25-26-20(17)30)13-4-3-5-15(12-13)33-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162044
PNG
(US9682991, 98)
Show SMILES CN(CCN1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N7O3/c1-29-8-13-34-18-17(29)20(30(2)6-7-31-9-11-33-12-10-31)28-32-19(26-27-21(18)32)15-4-3-5-16(14-15)35-22(23,24)25/h3-5,14H,6-13H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162047
PNG
(US9682991, 101)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(nn12)N1CCCCC1
Show InChI InChI=1S/C19H18F3N5O3/c20-19(21,22)30-13-6-4-5-12(11-13)16-23-24-17-14-15(29-10-9-28-14)18(25-27(16)17)26-7-2-1-3-8-26/h4-6,11H,1-3,7-10H2
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162048
PNG
(US9682991, 102)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(NCC3CC3)nn12
Show InChI InChI=1S/C18H16F3N5O3/c19-18(20,21)29-12-3-1-2-11(8-12)16-23-24-17-14-13(27-6-7-28-14)15(25-26(16)17)22-9-10-4-5-10/h1-3,8,10H,4-7,9H2,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM162048
PNG
(US9682991, 102)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2c3OCCOc3c(NCC3CC3)nn12
Show InChI InChI=1S/C18H16F3N5O3/c19-18(20,21)29-12-3-1-2-11(8-12)16-23-24-17-14-13(27-6-7-28-14)15(25-26(16)17)22-9-10-4-5-10/h1-3,8,10H,4-7,9H2,(H,22,25)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162049
PNG
(US9682991, 103)
Show InChI InChI=1S/C21H24F3N7O3/c1-29-8-11-33-17-16(29)18(25-14-6-9-31(2,32)10-7-14)28-30-19(26-27-20(17)30)13-4-3-5-15(12-13)34-21(22,23)24/h3-5,12,14H,6-11H2,1-2H3,(H,25,28)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161986
PNG
(US9682991, 35)
Show SMILES CN([C@H]1CC[C@H](O)CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1 |r,wU:2.1,wD:5.5,(-6.57,1.15,;-5.24,.38,;-5.24,-1.16,;-3.91,-1.93,;-3.91,-3.47,;-5.24,-4.23,;-5.24,-5.77,;-6.57,-3.47,;-6.57,-1.93,;-3.91,1.15,;-2.57,.39,;-1.24,1.15,;.23,.68,;1.13,1.92,;.23,3.17,;-1.24,2.69,;-2.57,3.46,;-2.57,5,;-3.91,5.77,;-5.24,5,;-5.24,3.46,;-6.57,2.69,;-3.91,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.49,-3.49,;2.11,-1.21,)|
Show InChI InChI=1/C22H25F3N6O3/c1-29-10-11-33-18-17(29)20(30(2)14-6-8-15(32)9-7-14)28-31-19(26-27-21(18)31)13-4-3-5-16(12-13)34-22(23,24)25/h3-5,12,14-15,32H,6-11H2,1-2H3/t14-,15-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM161986
PNG
(US9682991, 35)
Show SMILES CN([C@H]1CC[C@H](O)CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1 |r,wU:2.1,wD:5.5,(-6.57,1.15,;-5.24,.38,;-5.24,-1.16,;-3.91,-1.93,;-3.91,-3.47,;-5.24,-4.23,;-5.24,-5.77,;-6.57,-3.47,;-6.57,-1.93,;-3.91,1.15,;-2.57,.39,;-1.24,1.15,;.23,.68,;1.13,1.92,;.23,3.17,;-1.24,2.69,;-2.57,3.46,;-2.57,5,;-3.91,5.77,;-5.24,5,;-5.24,3.46,;-6.57,2.69,;-3.91,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.49,-3.49,;2.11,-1.21,)|
Show InChI InChI=1/C22H25F3N6O3/c1-29-10-11-33-18-17(29)20(30(2)14-6-8-15(32)9-7-14)28-31-19(26-27-21(18)31)13-4-3-5-16(12-13)34-22(23,24)25/h3-5,12,14-15,32H,6-11H2,1-2H3/t14-,15-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161990
PNG
(US9682991, 39)
Show SMILES CC1COc2c(N1C)c(NCC1CCN(C)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C23H28F3N7O2/c1-14-13-34-19-18(32(14)3)20(27-12-15-7-9-31(2)10-8-15)30-33-21(28-29-22(19)33)16-5-4-6-17(11-16)35-23(24,25)26/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161991
PNG
(US9682991, 40)
Show SMILES CC1CN(C)c2c(NCC3CCN(C)CC3)nn3c(nnc3c2O1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C23H28F3N7O2/c1-14-13-32(3)18-19(34-14)22-29-28-21(16-5-4-6-17(11-16)35-23(24,25)26)33(22)30-20(18)27-12-15-7-9-31(2)10-8-15/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM161991
PNG
(US9682991, 40)
Show SMILES CC1CN(C)c2c(NCC3CCN(C)CC3)nn3c(nnc3c2O1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C23H28F3N7O2/c1-14-13-32(3)18-19(34-14)22-29-28-21(16-5-4-6-17(11-16)35-23(24,25)26)33(22)30-20(18)27-12-15-7-9-31(2)10-8-15/h4-6,11,14-15H,7-10,12-13H2,1-3H3,(H,27,30)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161992
PNG
(US9682991, 41)
Show SMILES CN1CCC(CNc2nn3c(nnc3c3OCCOc23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C21H23F3N6O3/c1-29-7-5-13(6-8-29)12-25-18-16-17(32-10-9-31-16)20-27-26-19(30(20)28-18)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13H,5-10,12H2,1H3,(H,25,28)
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161994
PNG
(US9682991, 43)
Show SMILES CN1CCOc2c1c(NCC1CC[C@H](O)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wD:13.14,(-4.57,1.93,;-3.24,2.69,;-3.24,4.23,;-1.91,5,;-.57,4.23,;-.57,2.69,;-1.91,1.93,;-1.91,.38,;-3.24,-.38,;-3.24,-1.93,;-4.57,-2.69,;-4.57,-4.23,;-5.91,-5,;-7.24,-4.23,;-8.57,-5,;-7.24,-2.69,;-5.91,-1.92,;-.57,-.38,;.76,.38,;2.23,-.09,;3.13,1.15,;2.23,2.4,;.76,1.93,;2.62,-1.58,;1.54,-2.67,;1.93,-4.15,;3.42,-4.55,;4.51,-3.46,;6,-3.86,;7.09,-2.77,;8.57,-3.17,;6.69,-1.29,;8.18,-1.69,;4.11,-1.98,)|
Show InChI InChI=1/C22H25F3N6O3/c1-30-9-10-33-18-17(30)19(26-12-13-5-7-15(32)8-6-13)29-31-20(27-28-21(18)31)14-3-2-4-16(11-14)34-22(23,24)25/h2-4,11,13,15,32H,5-10,12H2,1H3,(H,26,29)/t13?,15-
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM161994
PNG
(US9682991, 43)
Show SMILES CN1CCOc2c1c(NCC1CC[C@H](O)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wD:13.14,(-4.57,1.93,;-3.24,2.69,;-3.24,4.23,;-1.91,5,;-.57,4.23,;-.57,2.69,;-1.91,1.93,;-1.91,.38,;-3.24,-.38,;-3.24,-1.93,;-4.57,-2.69,;-4.57,-4.23,;-5.91,-5,;-7.24,-4.23,;-8.57,-5,;-7.24,-2.69,;-5.91,-1.92,;-.57,-.38,;.76,.38,;2.23,-.09,;3.13,1.15,;2.23,2.4,;.76,1.93,;2.62,-1.58,;1.54,-2.67,;1.93,-4.15,;3.42,-4.55,;4.51,-3.46,;6,-3.86,;7.09,-2.77,;8.57,-3.17,;6.69,-1.29,;8.18,-1.69,;4.11,-1.98,)|
Show InChI InChI=1/C22H25F3N6O3/c1-30-9-10-33-18-17(30)19(26-12-13-5-7-15(32)8-6-13)29-31-20(27-28-21(18)31)14-3-2-4-16(11-14)34-22(23,24)25/h2-4,11,13,15,32H,5-10,12H2,1H3,(H,26,29)/t13?,15-
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161997
PNG
(US9682991, 48)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC2(CC(N)C2)CC1
Show InChI InChI=1S/C23H26F3N7O2/c1-31-9-10-34-18-17(31)20(32-7-5-22(6-8-32)12-15(27)13-22)30-33-19(28-29-21(18)33)14-3-2-4-16(11-14)35-23(24,25)26/h2-4,11,15H,5-10,12-13,27H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162053
PNG
(US9682991, 49)
Show SMILES CN1CCOc2c1c(NC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N7O2/c1-32-9-10-34-18-17(32)19(28-15-12-22(13-15)5-7-27-8-6-22)31-33-20(29-30-21(18)33)14-3-2-4-16(11-14)35-23(24,25)26/h2-4,11,15,27H,5-10,12-13H2,1H3,(H,28,31)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM161998
PNG
(US9682991, 50)
Show SMILES CC1COc2c(N1C)c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC2(CC(N)C2)CC1
Show InChI InChI=1/C24H28F3N7O2/c1-14-13-35-19-18(32(14)2)21(33-8-6-23(7-9-33)11-16(28)12-23)31-34-20(29-30-22(19)34)15-4-3-5-17(10-15)36-24(25,26)27/h3-5,10,14,16H,6-9,11-13,28H2,1-2H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162001
PNG
(US9682991, 54)
Show SMILES CN1CCOc2c1c(NCC13CCN(CC1)C3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-10-33-17-16(30)18(26-12-21-5-7-31(13-21)8-6-21)29-32-19(27-28-20(17)32)14-3-2-4-15(11-14)34-22(23,24)25/h2-4,11H,5-10,12-13H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162002
PNG
(US9682991, 55)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19(30-7-5-13(12-25)6-8-30)28-31-18(26-27-20(17)31)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM162002
PNG
(US9682991, 55)
Show SMILES CN1CCOc2c1c(nn1c(nnc21)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19(30-7-5-13(12-25)6-8-30)28-31-18(26-27-20(17)31)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162055
PNG
(US9682991, 56)
Show SMILES CN1CCOc2c1c(NCC1CCNCC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)18(26-12-13-5-7-25-8-6-13)29-31-19(27-28-20(17)31)14-3-2-4-15(11-14)33-21(22,23)24/h2-4,11,13,25H,5-10,12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162003
PNG
(US9682991, 57)
Show SMILES CN1CCOc2c(nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1)N1CCC(CN)CC1
Show InChI InChI=1S/C21H24F3N7O2/c1-29-9-10-32-17-16(29)19-27-26-18(14-3-2-4-15(11-14)33-21(22,23)24)31(19)28-20(17)30-7-5-13(12-25)6-8-30/h2-4,11,13H,5-10,12,25H2,1H3
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162056
PNG
(US9682991, 58)
Show SMILES CN1CCOc2c(NCC3CCNCC3)nn3c(nnc3c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)20-28-27-19(14-3-2-4-15(11-14)33-21(22,23)24)31(20)29-18(17)26-12-13-5-7-25-8-6-13/h2-4,11,13,25H,5-10,12H2,1H3,(H,26,29)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM162004
PNG
(US9682991, 59)
Show SMILES CN1CCOc2c1c(NCC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H28F3N7O2/c1-33-9-10-35-19-18(33)20(29-14-15-12-23(13-15)5-7-28-8-6-23)32-34-21(30-31-22(19)34)16-3-2-4-17(11-16)36-24(25,26)27/h2-4,11,15,28H,5-10,12-14H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM162004
PNG
(US9682991, 59)
Show SMILES CN1CCOc2c1c(NCC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H28F3N7O2/c1-33-9-10-35-19-18(33)20(29-14-15-12-23(13-15)5-7-28-8-6-23)32-34-21(30-31-22(19)34)16-3-2-4-17(11-16)36-24(25,26)27/h2-4,11,15,28H,5-10,12-14H2,1H3,(H,29,32)
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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...


US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair
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