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Compile Data Set for Download or QSAR

Found 64 hits with Last Name = 'boonnak' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50414391
PNG
(CHEMBL1202332 | CHEMBL553423)
Show SMILES NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)c(Cl)c1 |w:11.12|
Show InChI InChI=1S/C14H16Cl2N4S/c15-12-4-3-10(6-13(12)16)7-19-14(17)21-5-1-2-11-8-18-9-20-11/h3-4,6,8-9H,1-2,5,7H2,(H2,17,19)(H,18,20)
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1.58n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Agonistic activity at histamine H4 receptor


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418066
PNG
(CHEMBL1688976)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CC2CCCC2)nn1
Show InChI InChI=1S/C14H21N5/c1-2-5-12(4-1)8-14-10-19(18-17-14)7-3-6-13-9-15-11-16-13/h9-12H,1-8H2,(H,15,16)
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7.94n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418058
PNG
(CHEMBL1688946)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CC2CCCCC2)nn1
Show InChI InChI=1S/C15H23N5/c1-2-5-13(6-3-1)9-15-11-20(19-18-15)8-4-7-14-10-16-12-17-14/h10-13H,1-9H2,(H,16,17)
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8.32n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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11.8n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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12.0n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418064
PNG
(CHEMBL1688974)
Show SMILES CC(C1CCCCC1)c1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C16H25N5/c1-13(14-6-3-2-4-7-14)16-11-21(20-19-16)9-5-8-15-10-17-12-18-15/h10-14H,2-9H2,1H3,(H,17,18)
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21.4n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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29.5n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418062
PNG
(CHEMBL1688972)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CCC2CCCCC2)nn1
Show InChI InChI=1S/C16H25N5/c1-2-5-14(6-3-1)8-9-16-12-21(20-19-16)10-4-7-15-11-17-13-18-15/h11-14H,1-10H2,(H,17,18)
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36.3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418065
PNG
(CHEMBL1688975)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CC2CCCCCC2)nn1
Show InChI InChI=1S/C16H25N5/c1-2-4-7-14(6-3-1)10-16-12-21(20-19-16)9-5-8-15-11-17-13-18-15/h11-14H,1-10H2,(H,17,18)
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55.0n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418064
PNG
(CHEMBL1688974)
Show SMILES CC(C1CCCCC1)c1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C16H25N5/c1-13(14-6-3-2-4-7-14)16-11-21(20-19-16)9-5-8-15-10-17-12-18-15/h10-14H,2-9H2,1H3,(H,17,18)
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60.3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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63.1n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418057
PNG
(CHEMBL1688945)
Show SMILES CCCCCc1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C13H21N5/c1-2-3-4-6-13-10-18(17-16-13)8-5-7-12-9-14-11-15-12/h9-11H,2-8H2,1H3,(H,14,15)
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67.6n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418061
PNG
(CHEMBL1688971)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(nn1)C1CCCCC1
Show InChI InChI=1S/C14H21N5/c1-2-5-12(6-3-1)14-10-19(18-17-14)8-4-7-13-9-15-11-16-13/h9-12H,1-8H2,(H,15,16)
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70.8n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418059
PNG
(CHEMBL1688969)
Show SMILES C(Cn1cc(CC2CCCCC2)nn1)c1cnc[nH]1
Show InChI InChI=1S/C14H21N5/c1-2-4-12(5-3-1)8-14-10-19(18-17-14)7-6-13-9-15-11-16-13/h9-12H,1-8H2,(H,15,16)
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75.9n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418068
PNG
(CHEMBL1688978)
Show SMILES CC(C1CCCCC1)c1cn(CCc2cnc[nH]2)nn1
Show InChI InChI=1S/C15H23N5/c1-12(13-5-3-2-4-6-13)15-10-20(19-18-15)8-7-14-9-16-11-17-14/h9-13H,2-8H2,1H3,(H,16,17)
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75.9n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418079
PNG
(CHEMBL1688986)
Show SMILES C(Cc1cn(CC2CCCCC2)nn1)Cc1cnc[nH]1
Show InChI InChI=1S/C15H23N5/c1-2-5-13(6-3-1)10-20-11-15(18-19-20)8-4-7-14-9-16-12-17-14/h9,11-13H,1-8,10H2,(H,16,17)
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79.4n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418052
PNG
(CHEMBL1688940)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(Cc2ccccc2)nn1
Show InChI InChI=1S/C15H17N5/c1-2-5-13(6-3-1)9-15-11-20(19-18-15)8-4-7-14-10-16-12-17-14/h1-3,5-6,10-12H,4,7-9H2,(H,16,17)
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81.3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418061
PNG
(CHEMBL1688971)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(nn1)C1CCCCC1
Show InChI InChI=1S/C14H21N5/c1-2-5-12(6-3-1)14-10-19(18-17-14)8-4-7-13-9-15-11-16-13/h9-12H,1-8H2,(H,15,16)
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89.1n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418066
PNG
(CHEMBL1688976)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CC2CCCC2)nn1
Show InChI InChI=1S/C14H21N5/c1-2-5-12(4-1)8-14-10-19(18-17-14)7-3-6-13-9-15-11-16-13/h9-12H,1-8H2,(H,15,16)
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91.2n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418063
PNG
(CHEMBL1688973)
Show SMILES CCCCCCCc1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C15H25N5/c1-2-3-4-5-6-8-15-12-20(19-18-15)10-7-9-14-11-16-13-17-14/h11-13H,2-10H2,1H3,(H,16,17)
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97.7n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418056
PNG
(CHEMBL1688944)
Show SMILES CC(C)(C)c1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C12H19N5/c1-12(2,3)11-8-17(16-15-11)6-4-5-10-7-13-9-14-10/h7-9H,4-6H2,1-3H3,(H,13,14)
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100n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418057
PNG
(CHEMBL1688945)
Show SMILES CCCCCc1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C13H21N5/c1-2-3-4-6-13-10-18(17-16-13)8-5-7-12-9-14-11-15-12/h9-11H,2-8H2,1H3,(H,14,15)
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105n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418065
PNG
(CHEMBL1688975)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CC2CCCCCC2)nn1
Show InChI InChI=1S/C16H25N5/c1-2-4-7-14(6-3-1)10-16-12-21(20-19-16)9-5-8-15-11-17-13-18-15/h11-14H,1-10H2,(H,17,18)
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112n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418067
PNG
(CHEMBL1688977)
Show SMILES C(Cn1cc(CC2CCCC2)nn1)c1cnc[nH]1
Show InChI InChI=1S/C13H19N5/c1-2-4-11(3-1)7-13-9-18(17-16-13)6-5-12-8-14-10-15-12/h8-11H,1-7H2,(H,14,15)
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115n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418073
PNG
(CHEMBL1688983)
Show SMILES C(CN1CCCCC1)Cn1cc(CN2CCCCC2)nn1
Show InChI InChI=1S/C16H29N5/c1-3-8-19(9-4-1)12-7-13-21-15-16(17-18-21)14-20-10-5-2-6-11-20/h15H,1-14H2
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120n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418058
PNG
(CHEMBL1688946)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CC2CCCCC2)nn1
Show InChI InChI=1S/C15H23N5/c1-2-5-13(6-3-1)9-15-11-20(19-18-15)8-4-7-14-10-16-12-17-14/h10-13H,1-9H2,(H,16,17)
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126n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418062
PNG
(CHEMBL1688972)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CCC2CCCCC2)nn1
Show InChI InChI=1S/C16H25N5/c1-2-5-14(6-3-1)8-9-16-12-21(20-19-16)10-4-7-15-11-17-13-18-15/h11-14H,1-10H2,(H,17,18)
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141n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418052
PNG
(CHEMBL1688940)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(Cc2ccccc2)nn1
Show InChI InChI=1S/C15H17N5/c1-2-5-13(6-3-1)9-15-11-20(19-18-15)8-4-7-14-10-16-12-17-14/h1-3,5-6,10-12H,4,7-9H2,(H,16,17)
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182n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418056
PNG
(CHEMBL1688944)
Show SMILES CC(C)(C)c1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C12H19N5/c1-12(2,3)11-8-17(16-15-11)6-4-5-10-7-13-9-14-10/h7-9H,4-6H2,1-3H3,(H,13,14)
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191n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418078
PNG
(CHEMBL1688989)
Show SMILES C(Cc1cn(nn1)C1CCCCCC1)Cc1cnc[nH]1
Show InChI InChI=1S/C15H23N5/c1-2-4-9-15(8-3-1)20-11-14(18-19-20)7-5-6-13-10-16-12-17-13/h10-12,15H,1-9H2,(H,16,17)
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251n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418060
PNG
(CHEMBL1688970)
Show SMILES C(CCn1cc(CC2CCCCC2)nn1)Cc1cnc[nH]1
Show InChI InChI=1S/C16H25N5/c1-2-6-14(7-3-1)10-16-12-21(20-19-16)9-5-4-8-15-11-17-13-18-15/h11-14H,1-10H2,(H,17,18)
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275n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418060
PNG
(CHEMBL1688970)
Show SMILES C(CCn1cc(CC2CCCCC2)nn1)Cc1cnc[nH]1
Show InChI InChI=1S/C16H25N5/c1-2-6-14(7-3-1)10-16-12-21(20-19-16)9-5-4-8-15-11-17-13-18-15/h11-14H,1-10H2,(H,17,18)
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324n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418054
PNG
(CHEMBL1688942)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CN2CCCCC2)nn1
Show InChI InChI=1S/C14H22N6/c1-2-6-19(7-3-1)10-14-11-20(18-17-14)8-4-5-13-9-15-12-16-13/h9,11-12H,1-8,10H2,(H,15,16)
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380n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418080
PNG
(CHEMBL1688988)
Show SMILES C(Cc1cn(CCC2CCCCC2)nn1)Cc1cnc[nH]1
Show InChI InChI=1S/C16H25N5/c1-2-5-14(6-3-1)9-10-21-12-16(19-20-21)8-4-7-15-11-17-13-18-15/h11-14H,1-10H2,(H,17,18)
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380n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418074
PNG
(CHEMBL1688939)
Show SMILES C(Cn1cc(Cc2ccccc2)nn1)c1cnc[nH]1
Show InChI InChI=1S/C14H15N5/c1-2-4-12(5-3-1)8-14-10-19(18-17-14)7-6-13-9-15-11-16-13/h1-5,9-11H,6-8H2,(H,15,16)
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380n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418076
PNG
(CHEMBL1688985)
Show SMILES Clc1ccc(Cn2cc(CCCc3cnc[nH]3)nn2)cc1Cl
Show InChI InChI=1S/C15H15Cl2N5/c16-14-5-4-11(6-15(14)17)8-22-9-13(20-21-22)3-1-2-12-7-18-10-19-12/h4-7,9-10H,1-3,8H2,(H,18,19)
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447n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418075
PNG
(CHEMBL1688984)
Show SMILES C(Cc1cn(Cc2ccccc2)nn1)Cc1cnc[nH]1
Show InChI InChI=1S/C15H17N5/c1-2-5-13(6-3-1)10-20-11-15(18-19-20)8-4-7-14-9-16-12-17-14/h1-3,5-6,9,11-12H,4,7-8,10H2,(H,16,17)
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447n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418063
PNG
(CHEMBL1688973)
Show SMILES CCCCCCCc1cn(CCCc2cnc[nH]2)nn1
Show InChI InChI=1S/C15H25N5/c1-2-3-4-5-6-8-15-12-20(19-18-15)10-7-9-14-11-16-13-17-14/h11-13H,2-10H2,1H3,(H,16,17)
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457n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418072
PNG
(CHEMBL1688982)
Show SMILES C(CN1CCCCC1)Cn1cc(CC2CCCCC2)nn1
Show InChI InChI=1S/C17H30N4/c1-3-8-16(9-4-1)14-17-15-21(19-18-17)13-7-12-20-10-5-2-6-11-20/h15-16H,1-14H2
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490n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418067
PNG
(CHEMBL1688977)
Show SMILES C(Cn1cc(CC2CCCC2)nn1)c1cnc[nH]1
Show InChI InChI=1S/C13H19N5/c1-2-4-11(3-1)7-13-9-18(17-16-13)6-5-12-8-14-10-15-12/h8-11H,1-7H2,(H,14,15)
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589n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418077
PNG
(CHEMBL1688987)
Show SMILES C(Cc1cnc[nH]1)c1cn(CC2CCCCC2)nn1
Show InChI InChI=1S/C14H21N5/c1-2-4-12(5-3-1)9-19-10-14(17-18-19)7-6-13-8-15-11-16-13/h8,10-12H,1-7,9H2,(H,15,16)
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589n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418053
PNG
(CHEMBL1688941)
Show SMILES C(CCn1cc(Cc2ccccc2)nn1)Cc1cnc[nH]1
Show InChI InChI=1S/C16H19N5/c1-2-6-14(7-3-1)10-16-12-21(20-19-16)9-5-4-8-15-11-17-13-18-15/h1-3,6-7,11-13H,4-5,8-10H2,(H,17,18)
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589n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418059
PNG
(CHEMBL1688969)
Show SMILES C(Cn1cc(CC2CCCCC2)nn1)c1cnc[nH]1
Show InChI InChI=1S/C14H21N5/c1-2-4-12(5-3-1)8-14-10-19(18-17-14)7-6-13-9-15-11-16-13/h9-12H,1-8H2,(H,15,16)
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776n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418071
PNG
(CHEMBL1688981)
Show SMILES CN1CCN(CCCn2cc(CC3CCCCC3)nn2)CC1
Show InChI InChI=1S/C17H31N5/c1-20-10-12-21(13-11-20)8-5-9-22-15-17(18-19-22)14-16-6-3-2-4-7-16/h15-16H,2-14H2,1H3
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794n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418053
PNG
(CHEMBL1688941)
Show SMILES C(CCn1cc(Cc2ccccc2)nn1)Cc1cnc[nH]1
Show InChI InChI=1S/C16H19N5/c1-2-6-14(7-3-1)10-16-12-21(20-19-16)9-5-4-8-15-11-17-13-18-15/h1-3,6-7,11-13H,4-5,8-10H2,(H,17,18)
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912n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418074
PNG
(CHEMBL1688939)
Show SMILES C(Cn1cc(Cc2ccccc2)nn1)c1cnc[nH]1
Show InChI InChI=1S/C14H15N5/c1-2-4-12(5-3-1)8-14-10-19(18-17-14)7-6-13-9-15-11-16-13/h1-5,9-11H,6-8H2,(H,15,16)
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1.15E+3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418068
PNG
(CHEMBL1688978)
Show SMILES CC(C1CCCCC1)c1cn(CCc2cnc[nH]2)nn1
Show InChI InChI=1S/C15H23N5/c1-12(13-5-3-2-4-6-13)15-10-20(19-18-15)8-7-14-9-16-11-17-14/h9-13H,2-8H2,1H3,(H,16,17)
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1.15E+3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418054
PNG
(CHEMBL1688942)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CN2CCCCC2)nn1
Show InChI InChI=1S/C14H22N6/c1-2-6-19(7-3-1)10-14-11-20(18-17-14)8-4-5-13-9-15-12-16-13/h9,11-12H,1-8,10H2,(H,15,16)
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1.82E+3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50418055
PNG
(CHEMBL1688943)
Show SMILES CN1CCN(Cc2cn(CCCc3cnc[nH]3)nn2)CC1
Show InChI InChI=1S/C14H23N7/c1-19-5-7-20(8-6-19)10-14-11-21(18-17-14)4-2-3-13-9-15-12-16-13/h9,11-12H,2-8,10H2,1H3,(H,15,16)
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2.69E+3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50418070
PNG
(CHEMBL1688980)
Show SMILES C(CN1CCOCC1)Cn1cc(CC2CCCCC2)nn1
Show InChI InChI=1S/C16H28N4O/c1-2-5-15(6-3-1)13-16-14-20(18-17-16)8-4-7-19-9-11-21-12-10-19/h14-15H,1-13H2
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4.79E+3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 54: 1693-703 (2011)


Article DOI: 10.1021/jm1013488
BindingDB Entry DOI: 10.7270/Q20G3MDD
More data for this
Ligand-Target Pair
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