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Compile Data Set for Download or QSAR

Found 236 hits with Last Name = 'briggs' and Initial = 'jm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine deaminase


(Homo sapiens (Human))
BDBM50407749
PNG
(CHEMBL2112110)
Show SMILES OC[C@@H]1O[C@@H](C[C@H]1O)n1cnc2[C@H](O)CCC=Nc12 |c:17|
Show InChI InChI=1S/C12H17N3O4/c16-5-9-8(18)4-10(19-9)15-6-14-11-7(17)2-1-3-13-12(11)15/h3,6-10,16-18H,1-2,4-5H2/t7-,8-,9+,10+/m1/s1
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0.00250n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity towards Adenosine deaminase


J Med Chem 39: 277-84 (1996)


Article DOI: 10.1021/jm9505674
BindingDB Entry DOI: 10.7270/Q2ZS2X6V
More data for this
Ligand-Target Pair
Adenosine deaminase


(Homo sapiens (Human))
BDBM50369126
PNG
(CONFORMYCIN)
Show SMILES OC[C@@H]1OC([C@@H](O)[C@H]1O)n1cnc2[C@H](O)CCC=Nc12 |r,c:18|
Show InChI InChI=1S/C12H17N3O5/c16-4-7-9(18)10(19)12(20-7)15-5-14-8-6(17)2-1-3-13-11(8)15/h3,5-7,9-10,12,16-19H,1-2,4H2/t6-,7+,9+,10+,12?/m1/s1
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0.0100n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity towards Adenosine deaminase


J Med Chem 39: 277-84 (1996)


Article DOI: 10.1021/jm9505674
BindingDB Entry DOI: 10.7270/Q2ZS2X6V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50123468
PNG
(CHEMBL32865 | [3-Benzyl-5-(1,1-dioxo-1lambda 6 -is...)
Show SMILES Oc1c(ncc2cccnc12)C(=O)c1cc(CN2CCCS2(=O)=O)cc(Cc2ccccc2)c1
Show InChI InChI=1S/C26H23N3O4S/c30-25(24-26(31)23-21(16-28-24)8-4-9-27-23)22-14-19(12-18-6-2-1-3-7-18)13-20(15-22)17-29-10-5-11-34(29,32)33/h1-4,6-9,13-16,31H,5,10-12,17H2
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n/an/a 10n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50123469
PNG
((3-Benzyl-phenyl)-(8-hydroxy-[1,6]naphthyridin-7-y...)
Show SMILES Oc1c(ncc2cccnc12)C(=O)c1cccc(Cc2ccccc2)c1
Show InChI InChI=1S/C22H16N2O2/c25-21(20-22(26)19-18(14-24-20)10-5-11-23-19)17-9-4-8-16(13-17)12-15-6-2-1-3-7-15/h1-11,13-14,26H,12H2
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n/an/a 40n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM107681
PNG
((2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxo...)
Show SMILES OC(=O)C(=O)CC(=O)c1cc(OCc2ccccc2)cc(OCc2ccccc2)c1
Show InChI InChI=1S/C24H20O6/c25-22(14-23(26)24(27)28)19-11-20(29-15-17-7-3-1-4-8-17)13-21(12-19)30-16-18-9-5-2-6-10-18/h1-13H,14-16H2,(H,27,28)
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n/an/a 59n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141234
PNG
(CHEMBL409132 | N,N'-Bis-(4-{4-[4-(3-dimethylamino-...)
Show SMILES CC1C=C(NC(=O)C2=CC(NC(=O)C3=CC(=CC3C)N(C)C(=O)c3ccc(cc3)C(=O)N(C)C3=CC(C)C(=C3)C(=O)NC3=CC(C)C(=C3)C(=O)NC3=CC(C)C(=C3)C(=O)NCCCN(C)C)=CC2C)C=C1C(=O)NCCCN(C)C |c:15,39,49,59,70,75,t:2,7,13,35,45,55|
Show InChI InChI=1S/C62H76N10O8/c1-35-23-43(29-49(35)55(73)63-19-13-21-69(7)8)65-57(75)51-31-45(25-37(51)3)67-59(77)53-33-47(27-39(53)5)71(11)61(79)41-15-17-42(18-16-41)62(80)72(12)48-28-40(6)54(34-48)60(78)68-46-26-38(4)52(32-46)58(76)66-44-24-36(2)50(30-44)56(74)64-20-14-22-70(9)10/h15-18,23-40H,13-14,19-22H2,1-12H3,(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,67,77)(H,68,78)
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n/an/a 70n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141236
PNG
(CHEMBL216058 | N,N'-Bis-(4-{4-[4-(2-carbamimidoyl-...)
Show SMILES CC1C=C(NC(=O)C2=CC(NC(=O)C3=CC(NC(=O)c4ccc(cc4)C(=O)NC4=CC(C)C(=C4)C(=O)NC4=CC(C)C(=C4)C(=O)NC4=CC(C)C(=C4)C(=O)NCCC(N)=N)=CC3C)=CC2C)C=C1C(=O)NCCC(N)=N |c:33,43,53,63,67,72,t:2,7,13,29,39,49|
Show InChI InChI=1S/C56H62N12O8/c1-27-15-37(21-41(27)51(71)61-13-11-47(57)58)65-55(75)45-25-39(19-31(45)5)67-53(73)43-23-35(17-29(43)3)63-49(69)33-7-9-34(10-8-33)50(70)64-36-18-30(4)44(24-36)54(74)68-40-20-32(6)46(26-40)56(76)66-38-16-28(2)42(22-38)52(72)62-14-12-48(59)60/h7-10,15-32H,11-14H2,1-6H3,(H3,57,58)(H3,59,60)(H,61,71)(H,62,72)(H,63,69)(H,64,70)(H,65,75)(H,66,76)(H,67,73)(H,68,74)
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n/an/a 90n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141242
PNG
(CHEMBL403498 | Pyridine-2,5-dicarboxylic acid bis-...)
Show SMILES CC1C=C(NC(=O)C2=CC(NC(=O)C3=CC(NC(=O)c4ccc(nc4)C(=O)NC4=CC(C)C(=C4)C(=O)NC4=CC(C)C(=C4)C(=O)NC4=CC(C)C(=C4)C(=O)NCCC(N)=N)=CC3C)=CC2C)C=C1C(=O)NCCC(N)=N |c:33,43,53,63,67,72,t:2,7,13,29,39,49|
Show InChI InChI=1S/C55H61N13O8/c1-26-13-34(19-39(26)49(70)60-11-9-46(56)57)64-52(73)42-22-36(16-29(42)4)66-51(72)41-21-33(15-28(41)3)63-48(69)32-7-8-45(62-25-32)55(76)68-38-18-31(6)44(24-38)54(75)67-37-17-30(5)43(23-37)53(74)65-35-14-27(2)40(20-35)50(71)61-12-10-47(58)59/h7-8,13-31H,9-12H2,1-6H3,(H3,56,57)(H3,58,59)(H,60,70)(H,61,71)(H,63,69)(H,64,73)(H,65,74)(H,66,72)(H,67,75)(H,68,76)
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n/an/a 100n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM23399
PNG
(4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccn1Cc1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO4/c16-11-5-3-10(4-6-11)9-17-7-1-2-12(17)13(18)8-14(19)15(20)21/h1-7H,8-9H2,(H,20,21)
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n/an/a 126n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50073630
PNG
(2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]...)
Show SMILES OC(=O)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+
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n/an/a 130n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267441
PNG
(CHEMBL470227 | pCinn-Leu-Pro-Gln-Thr-NH2)
Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r|
Show InChI InChI=1S/C29H43N6O11P/c1-16(2)15-21(32-24(38)13-8-18-6-9-19(10-7-18)46-47(43,44)45)29(42)35-14-4-5-22(35)28(41)33-20(11-12-23(30)37)27(40)34-25(17(3)36)26(31)39/h6-10,13,16-17,20-22,25,36H,4-5,11-12,14-15H2,1-3H3,(H2,30,37)(H2,31,39)(H,32,38)(H,33,41)(H,34,40)(H2,43,44,45)/b13-8+/t17-,20+,21+,22+,25+/m1/s1
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n/an/a 136n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50198780
PNG
(4-(3-((S)-1-((S)-2-((S)-5-amino-1-(benzylamino)-1,...)
Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C32H42N5O9P/c1-21(2)19-26(35-29(39)17-12-22-10-13-24(14-11-22)46-47(43,44)45)32(42)37-18-6-9-27(37)31(41)36-25(15-16-28(33)38)30(40)34-20-23-7-4-3-5-8-23/h3-5,7-8,10-14,17,21,25-27H,6,9,15-16,18-20H2,1-2H3,(H2,33,38)(H,34,40)(H,35,39)(H,36,41)(H2,43,44,45)/b17-12+/t25-,26-,27-/m0/s1
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n/an/a 138n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267457
PNG
((S)-methyl 5-amino-5-oxo-2-((3S,6S)-4-oxo-3-(3-(4-...)
Show SMILES COC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23 |r|
Show InChI InChI=1S/C28H31N4O10P/c1-41-28(37)21(12-13-23(29)33)31-26(35)22-15-18-4-2-3-17-8-11-20(27(36)32(22)25(17)18)30-24(34)14-7-16-5-9-19(10-6-16)42-43(38,39)40/h2-7,9-10,14,20-22H,8,11-13,15H2,1H3,(H2,29,33)(H,30,34)(H,31,35)(H2,38,39,40)/b14-7+/t20-,21-,22-/m0/s1
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n/an/a 141n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50073630
PNG
(2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]...)
Show SMILES OC(=O)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+
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n/an/a 150n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267451
PNG
(4-(3-((3S,6S)-6-((S)-5-amino-1-(benzylamino)-1,5-d...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C34H36N5O9P/c35-29(40)17-16-26(32(42)36-20-22-5-2-1-3-6-22)38-33(43)28-19-24-8-4-7-23-12-15-27(34(44)39(28)31(23)24)37-30(41)18-11-21-9-13-25(14-10-21)48-49(45,46)47/h1-11,13-14,18,26-28H,12,15-17,19-20H2,(H2,35,40)(H,36,42)(H,37,41)(H,38,43)(H2,45,46,47)/b18-11+/t26-,27-,28-/m0/s1
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n/an/a 162n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267442
PNG
(CHEMBL485921 | pInd-Leu-Pro-Gln-Thr-NH2)
Show SMILES CC(C)C[C@H](NC(=O)c1cc2cc(OP(O)(O)=O)ccc2[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r|
Show InChI InChI=1S/C29H42N7O11P/c1-14(2)11-21(34-27(41)20-13-16-12-17(47-48(44,45)46)6-7-18(16)32-20)29(43)36-10-4-5-22(36)28(42)33-19(8-9-23(30)38)26(40)35-24(15(3)37)25(31)39/h6-7,12-15,19,21-22,24,32,37H,4-5,8-11H2,1-3H3,(H2,30,38)(H2,31,39)(H,33,42)(H,34,41)(H,35,40)(H2,44,45,46)/t15-,19+,21+,22+,24+/m1/s1
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n/an/a 186n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267453
PNG
(2-((3S,6S)-6-((S)-5-amino-1-(benzylamino)-1,5-diox...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)c4cc5cc(OP(O)(O)=O)ccc5[nH]4)C(=O)N1c23)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C34H35N6O9P/c35-29(41)14-13-25(31(42)36-18-19-5-2-1-3-6-19)38-33(44)28-17-21-8-4-7-20-9-11-26(34(45)40(28)30(20)21)39-32(43)27-16-22-15-23(49-50(46,47)48)10-12-24(22)37-27/h1-8,10,12,15-16,25-26,28,37H,9,11,13-14,17-18H2,(H2,35,41)(H,36,42)(H,38,44)(H,39,43)(H2,46,47,48)/t25-,26-,28-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267452
PNG
(4-(3-((2S,5S,Z)-2-((S)-5-amino-1-(benzylamino)-1,5...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3C=C[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23)C(=O)NCc1ccccc1 |r,c:16|
Show InChI InChI=1S/C34H34N5O9P/c35-29(40)17-16-26(32(42)36-20-22-5-2-1-3-6-22)38-33(43)28-19-24-8-4-7-23-12-15-27(34(44)39(28)31(23)24)37-30(41)18-11-21-9-13-25(14-10-21)48-49(45,46)47/h1-15,18,26-28H,16-17,19-20H2,(H2,35,40)(H,36,42)(H,37,41)(H,38,43)(H2,45,46,47)/b18-11+/t26-,27-,28-/m0/s1
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n/an/a 195n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141230
PNG
(3-Carboxy-2-(3,4-dihydroxy-benzyl)-4-(3,4-dihydrox...)
Show SMILES CC(Cc1ccc(O)c(O)c1)(C(O)=O)C(C)(Cc1ccc(O)c(O)c1)C([O-])=O
Show InChI InChI=1S/C20H22O8/c1-19(17(25)26,9-11-3-5-13(21)15(23)7-11)20(2,18(27)28)10-12-4-6-14(22)16(24)8-12/h3-8,21-24H,9-10H2,1-2H3,(H,25,26)(H,27,28)/p-1
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n/an/a 230n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267440
PNG
(4-((S)-2-acetamido-3-((3S,6S)-6-((S)-5-amino-1-((2...)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)[C@H](Cc4ccc(OP(O)(O)=O)cc4)NC(C)=O)C(=O)N1c23)C(N)=O |r|
Show InChI InChI=1S/C33H42N7O12P/c1-16(41)27(29(35)44)39-30(45)22(12-13-26(34)43)37-32(47)25-15-20-5-3-4-19-8-11-23(33(48)40(25)28(19)20)38-31(46)24(36-17(2)42)14-18-6-9-21(10-7-18)52-53(49,50)51/h3-7,9-10,16,22-25,27,41H,8,11-15H2,1-2H3,(H2,34,43)(H2,35,44)(H,36,42)(H,37,47)(H,38,46)(H,39,45)(H2,49,50,51)/t16-,22+,23+,24+,25+,27+/m1/s1
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n/an/a 231n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267458
PNG
(4-(3-((3S,6S)-6-((S)-1,5-diamino-1,5-dioxopentan-2...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23)C(N)=O |r|
Show InChI InChI=1S/C27H30N5O9P/c28-22(33)12-11-19(25(29)35)31-26(36)21-14-17-3-1-2-16-7-10-20(27(37)32(21)24(16)17)30-23(34)13-6-15-4-8-18(9-5-15)41-42(38,39)40/h1-6,8-9,13,19-21H,7,10-12,14H2,(H2,28,33)(H2,29,35)(H,30,34)(H,31,36)(H2,38,39,40)/b13-6+/t19-,20-,21-/m0/s1
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n/an/a 233n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50056908
PNG
((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Show SMILES O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
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n/an/a 250n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141240
PNG
((Z)-4-(3,4-Bis-azidomethyl-phenyl)-2-hydroxy-4-oxo...)
Show SMILES [O-]C(=O)C(=O)CC(=O)c1ccc(CN=[N+]=[N-])c(CN=[N+]=[N-])c1
Show InChI InChI=1S/C12H10N6O4/c13-17-15-5-8-2-1-7(3-9(8)6-16-18-14)10(19)4-11(20)12(21)22/h1-3H,4-6H2,(H,21,22)/p-1
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n/an/a 260n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267459
PNG
(4-(3-((3S,6S)-6-((S)-5-amino-1-(methylamino)-1,5-d...)
Show SMILES CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23 |r|
Show InChI InChI=1S/C28H32N5O9P/c1-30-26(36)20(12-13-23(29)34)32-27(37)22-15-18-4-2-3-17-8-11-21(28(38)33(22)25(17)18)31-24(35)14-7-16-5-9-19(10-6-16)42-43(39,40)41/h2-7,9-10,14,20-22H,8,11-13,15H2,1H3,(H2,29,34)(H,30,36)(H,31,35)(H,32,37)(H2,39,40,41)/b14-7+/t20-,21-,22-/m0/s1
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n/an/a 269n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM20193
PNG
(1, Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 | 4-[(2S)-2-{[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O |r|
Show InChI InChI=1S/C36H57N8O13P/c1-18(2)16-26(41-33(50)25(39-21(6)46)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)44-15-7-8-27(44)34(51)40-24(13-14-28(37)47)32(49)43-30(20(5)45)35(52)42-29(19(3)4)31(38)48/h9-12,18-20,24-27,29-30,45H,7-8,13-17H2,1-6H3,(H2,37,47)(H2,38,48)(H,39,46)(H,40,51)(H,41,50)(H,42,52)(H,43,49)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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n/an/a 290n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50088352
PNG
(4-Dimethylamino-3,6,12-trihydroxy-6,10-dimethyl-1,...)
Show SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C2C(=O)C(C(=O)NCN2CCN(CC2)C(N)=NC(N)=N)C1=O)C(=O)c1c(C)cccc1C3(C)O |w:26.28|
Show InChI InChI=1S/C30H40N8O6/c1-14-6-5-7-16-18(14)23(39)20-17(30(16,2)44)12-15-19(24(20)40)25(41)21(26(42)22(15)36(3)4)27(43)34-13-37-8-10-38(11-9-37)29(33)35-28(31)32/h5-7,15,17,19-22,44H,8-13H2,1-4H3,(H,34,43)(H5,31,32,33,35)/t15-,17+,19?,20?,21?,22+,30?/m1/s1
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n/an/a 300n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267460
PNG
(4-(3-((3S,6S)-6-((S)-5-amino-1-(isopropylamino)-1,...)
Show SMILES CC(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23 |r|
Show InChI InChI=1S/C30H36N5O9P/c1-17(2)32-28(38)22(13-14-25(31)36)34-29(39)24-16-20-5-3-4-19-9-12-23(30(40)35(24)27(19)20)33-26(37)15-8-18-6-10-21(11-7-18)44-45(41,42)43/h3-8,10-11,15,17,22-24H,9,12-14,16H2,1-2H3,(H2,31,36)(H,32,38)(H,33,37)(H,34,39)(H2,41,42,43)/b15-8+/t22-,23-,24-/m0/s1
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n/an/a 305n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141226
PNG
((Z)-4-(5,8-Diazido-5,6,7,8-tetrahydro-naphthalen-2...)
Show SMILES [O-]C(=O)C(=O)CC(=O)c1ccc2C(CCC(N=[N+]=[N-])c2c1)N=[N+]=[N-]
Show InChI InChI=1S/C14H12N6O4/c15-19-17-10-3-4-11(18-20-16)9-5-7(1-2-8(9)10)12(21)6-13(22)14(23)24/h1-2,5,10-11H,3-4,6H2,(H,23,24)/p-1
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n/an/a 320n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50055711
PNG
(3-[4-di(4,7-dihydroxy-2-oxo-2H-3-chromenyl)methylp...)
Show SMILES Oc1ccc2c(O)c(C(c3ccc(cc3)C(c3c(O)c4ccc(O)cc4oc3=O)c3c(O)c4ccc(O)cc4oc3=O)c3c(O)c4ccc(O)cc4oc3=O)c(=O)oc2c1
Show InChI InChI=1S/C44H26O16/c45-19-5-9-23-27(13-19)57-41(53)33(37(23)49)31(34-38(50)24-10-6-20(46)14-28(24)58-42(34)54)17-1-2-18(4-3-17)32(35-39(51)25-11-7-21(47)15-29(25)59-43(35)55)36-40(52)26-12-8-22(48)16-30(26)60-44(36)56/h1-16,31-32,45-52H
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n/an/a 330n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267456
PNG
((S)-5-amino-5-oxo-2-((3S,6S)-4-oxo-3-(3-(4-(phosph...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23)C(O)=O |r|
Show InChI InChI=1S/C27H29N4O10P/c28-22(32)12-11-20(27(36)37)30-25(34)21-14-17-3-1-2-16-7-10-19(26(35)31(21)24(16)17)29-23(33)13-6-15-4-8-18(9-5-15)41-42(38,39)40/h1-6,8-9,13,19-21H,7,10-12,14H2,(H2,28,32)(H,29,33)(H,30,34)(H,36,37)(H2,38,39,40)/b13-6+/t19-,20-,21-/m0/s1
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n/an/a 359n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141233
PNG
((Z)-4-(1,3-Diazido-indan-5-yl)-2-hydroxy-4-oxo-but...)
Show SMILES [O-]C(=O)C(=O)CC(=O)c1ccc2C(CC(N=[N+]=[N-])c2c1)N=[N+]=[N-]
Show InChI InChI=1S/C13H10N6O4/c14-18-16-9-4-10(17-19-15)8-3-6(1-2-7(8)9)11(20)5-12(21)13(22)23/h1-3,9-10H,4-5H2,(H,22,23)/p-1
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n/an/a 360n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141232
PNG
(3-[3-((E)-3,4-Dihydroxy-phenyl)-acryloylamino]-2-[...)
Show SMILES Oc1ccc(\C=C\C(=O)NCC(OC(=O)\C=C\c2ccc(O)c(O)c2)C([O-])=O)cc1O
Show InChI InChI=1S/C21H19NO9/c23-14-5-1-12(9-16(14)25)3-7-19(27)22-11-18(21(29)30)31-20(28)8-4-13-2-6-15(24)17(26)10-13/h1-10,18,23-26H,11H2,(H,22,27)(H,29,30)/p-1/b7-3+,8-4+
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n/an/a 370n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50123470
PNG
((3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methan...)
Show SMILES Oc1c(ccc2cccnc12)C(=O)c1cccc(Cc2ccccc2)c1
Show InChI InChI=1S/C23H17NO2/c25-22(20-12-11-18-10-5-13-24-21(18)23(20)26)19-9-4-8-17(15-19)14-16-6-2-1-3-7-16/h1-13,15,26H,14H2
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n/an/a 370n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM20233
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamo...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C34H47N6O10P/c1-21(2)18-28(39-32(44)27(37-22(3)41)19-23-11-13-25(14-12-23)50-51(47,48)49)34(46)40-17-7-10-29(40)33(45)38-26(15-16-30(35)42)31(43)36-20-24-8-5-4-6-9-24/h4-6,8-9,11-14,21,26-29H,7,10,15-20H2,1-3H3,(H2,35,42)(H,36,43)(H,37,41)(H,38,45)(H,39,44)(H2,47,48,49)/t26-,27-,28-,29-/m0/s1
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n/an/a 409n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50141230
PNG
(3-Carboxy-2-(3,4-dihydroxy-benzyl)-4-(3,4-dihydrox...)
Show SMILES CC(Cc1ccc(O)c(O)c1)(C(O)=O)C(C)(Cc1ccc(O)c(O)c1)C([O-])=O
Show InChI InChI=1S/C20H22O8/c1-19(17(25)26,9-11-3-5-13(21)15(23)7-11)20(2,18(27)28)10-12-4-6-14(22)16(24)8-12/h3-8,21-24H,9-10H2,1-2H3,(H,25,26)(H,27,28)/p-1
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n/an/a 440n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50056908
PNG
((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Show SMILES O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50088358
PNG
(4-Dimethylamino-3,6,12-trihydroxy-6,10-dimethyl-1,...)
Show SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C2C(=O)C(C(=O)NCNC(CO)(CO)CO)C1=O)C(=O)c1c(C)cccc1C3(C)O
Show InChI InChI=1S/C28H37N3O9/c1-13-6-5-7-15-17(13)22(35)19-16(27(15,2)40)8-14-18(23(19)36)24(37)20(25(38)21(14)31(3)4)26(39)29-12-30-28(9-32,10-33)11-34/h5-7,14,16,18-21,30,32-34,40H,8-12H2,1-4H3,(H,29,39)/t14-,16+,18?,19?,20?,21+,27?/m1/s1
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n/an/a 500n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50056908
PNG
((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Show SMILES O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
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n/an/a 540n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267455
PNG
(4-(3-((3S,6S)-6-(3-carbamoylpyrrolidine-1-carbonyl...)
Show SMILES NC(=O)C1CCN(C1)C(=O)[C@@H]1Cc2cccc3CC[C@H](NC(=O)\C=C\c4ccc(OP(O)(O)=O)cc4)C(=O)N1c23 |r|
Show InChI InChI=1S/C27H29N4O8P/c28-25(33)19-12-13-30(15-19)27(35)22-14-18-3-1-2-17-7-10-21(26(34)31(22)24(17)18)29-23(32)11-6-16-4-8-20(9-5-16)39-40(36,37)38/h1-6,8-9,11,19,21-22H,7,10,12-15H2,(H2,28,33)(H,29,32)(H2,36,37,38)/b11-6+/t19?,21-,22-/m0/s1
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n/an/a 595n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 600n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50056937
PNG
(3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoi...)
Show SMILES OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1
Show InChI InChI=1S/C14H10O9/c15-7-2-6(3-8(16)11(7)18)14(22)23-10-4-5(13(20)21)1-9(17)12(10)19/h1-4,15-19H,(H,20,21)
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n/an/a 600n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50066325
PNG
(2-(2-Hydroxy-benzoyl)-4-[1-(4-methoxy-phenyl)-meth...)
Show SMILES COc1ccc(C=c2c(=C)[nH]n(C(=O)c3ccccc3O)c2=O)cc1 |w:6.5|
Show InChI InChI=1S/C19H16N2O4/c1-12-16(11-13-7-9-14(25-2)10-8-13)19(24)21(20-12)18(23)15-5-3-4-6-17(15)22/h3-11,20,22H,1H2,2H3
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n/an/a 600n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50123472
PNG
(7-Benzyl-1,2-dihydroxy-xanthen-9-one | CHEMBL28809...)
Show SMILES Oc1ccc2oc3ccc(Cc4ccccc4)cc3c(=O)c2c1O
Show InChI InChI=1S/C20H14O4/c21-15-7-9-17-18(20(15)23)19(22)14-11-13(6-8-16(14)24-17)10-12-4-2-1-3-5-12/h1-9,11,21,23H,10H2
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n/an/a 600n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM23408
PNG
(2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-ch...)
Show SMILES Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
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n/an/a 600n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50267448
PNG
(4-(3-((3S,6S,8aS)-3-((S)-5-amino-1-(benzylamino)-1...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CC[C@H](NC(=O)\C=C\c3ccc(OP(O)(O)=O)cc3)C(=O)N12)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C30H36N5O9P/c31-26(36)16-14-23(28(38)32-18-20-4-2-1-3-5-20)34-29(39)25-15-10-21-9-13-24(30(40)35(21)25)33-27(37)17-8-19-6-11-22(12-7-19)44-45(41,42)43/h1-8,11-12,17,21,23-25H,9-10,13-16,18H2,(H2,31,36)(H,32,38)(H,33,37)(H,34,39)(H2,41,42,43)/b17-8+/t21-,23-,24-,25-/m0/s1
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n/an/a 604n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50088359
PNG
(3,5-Bis-[3-(3,4-dihydroxy-phenyl)-acryloyloxy]-1,4...)
Show SMILES OC1C(CC(O)(CC1OC(=O)\C=C/c1ccc(O)c(O)c1)C(O)=O)OC(=O)\C=C/c1ccc(O)c(O)c1 |(5.46,-3.6,;5.46,-2.24,;6.59,-.7,;8.81,-.7,;9.95,-2.24,;9.95,-3.8,;8.81,-3.69,;6.59,-3.69,;6.59,-5.2,;7.98,-5.83,;9.35,-5.13,;7.98,-7.41,;9.28,-8.06,;10.55,-7.19,;10.55,-5.53,;11.74,-4.69,;13.18,-5.43,;14.54,-4.77,;13.18,-7.23,;14.57,-7.85,;11.91,-7.88,;9.95,-.68,;11.38,.16,;8.79,.5,;6.63,.6,;4.99,1.65,;3.59,.89,;4.99,3.31,;3.7,4.06,;2.43,3.26,;2.43,1.78,;1.1,1.09,;-.16,1.85,;-1.52,1.15,;-.16,3.31,;-1.48,4.11,;1.14,4.04,)|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(30)36-19-11-25(35,24(33)34)12-20(23(19)32)37-22(31)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-29,32,35H,11-12H2,(H,33,34)/b7-3-,8-4-
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n/an/a 640n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50088359
PNG
(3,5-Bis-[3-(3,4-dihydroxy-phenyl)-acryloyloxy]-1,4...)
Show SMILES OC1C(CC(O)(CC1OC(=O)\C=C/c1ccc(O)c(O)c1)C(O)=O)OC(=O)\C=C/c1ccc(O)c(O)c1 |(5.46,-3.6,;5.46,-2.24,;6.59,-.7,;8.81,-.7,;9.95,-2.24,;9.95,-3.8,;8.81,-3.69,;6.59,-3.69,;6.59,-5.2,;7.98,-5.83,;9.35,-5.13,;7.98,-7.41,;9.28,-8.06,;10.55,-7.19,;10.55,-5.53,;11.74,-4.69,;13.18,-5.43,;14.54,-4.77,;13.18,-7.23,;14.57,-7.85,;11.91,-7.88,;9.95,-.68,;11.38,.16,;8.79,.5,;6.63,.6,;4.99,1.65,;3.59,.89,;4.99,3.31,;3.7,4.06,;2.43,3.26,;2.43,1.78,;1.1,1.09,;-.16,1.85,;-1.52,1.15,;-.16,3.31,;-1.48,4.11,;1.14,4.04,)|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(30)36-19-11-25(35,24(33)34)12-20(23(19)32)37-22(31)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-29,32,35H,11-12H2,(H,33,34)/b7-3-,8-4-
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n/an/a 660n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50088356
PNG
(1,3-Bis-[3-(3,4-dihydroxy-phenyl)-acryloyloxy]-4,5...)
Show SMILES OC1CC(CC(OC(=O)\C=C/c2ccc(O)c(O)c2)C1O)(OC(=O)\C=C/c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(24(34)35,11-19(30)23(20)33)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,33H,11-12H2,(H,34,35)/b7-3-,8-4-
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n/an/a 680n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing


J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM50056891
PNG
(2-Hydroxy-benzoic acid N'-(2-hydroxy-benzoyl)-hydr...)
Show SMILES Oc1ccccc1C(=O)NNC(=O)c1ccccc1O
Show InChI InChI=1S/C14H12N2O4/c17-11-7-3-1-5-9(11)13(19)15-16-14(20)10-6-2-4-8-12(10)18/h1-8,17-18H,(H,15,19)(H,16,20)
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n/an/a 700n/an/an/an/an/an/a



University of Houston

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase


Bioorg Med Chem Lett 14: 1447-54 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.027
BindingDB Entry DOI: 10.7270/Q2B858PN
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM20195
PNG
(2, Ac-pTyr-Leu-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C31H48N7O12P/c1-16(2)14-23(36-29(44)22(34-18(4)40)15-19-7-9-20(10-8-19)50-51(47,48)49)31(46)38-13-5-6-24(38)30(45)35-21(11-12-25(32)41)28(43)37-26(17(3)39)27(33)42/h7-10,16-17,21-24,26,39H,5-6,11-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 739n/an/an/an/an/an/a



The University of Texas M. D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Stat3 (unknown origin) by fluorescence polarization assay


J Med Chem 52: 2429-42 (2009)


Article DOI: 10.1021/jm801491w
BindingDB Entry DOI: 10.7270/Q28C9W4V
More data for this
Ligand-Target Pair
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