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Compile Data Set for Download or QSAR

Found 88 hits with Last Name = 'campen' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060785
PNG
(CHEMBL268095 | [D or LAgl (hydroxyacetic acid)4]ac...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@@H](NC(=O)CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)37-63(73(105)90-62(18-11-12-35-85-47(3)4)81(113)98-36-14-19-69(98)79(111)86-48(5)71(83)104)91-75(107)66(40-53-23-30-60(31-24-53)87-49(6)100)93-77(109)67(41-54-25-32-61(33-26-54)88-50(7)101)95-80(112)72(96-70(103)45-99)97-78(110)68(43-56-15-13-34-84-44-56)94-76(108)65(39-52-21-28-59(82)29-22-52)92-74(106)64(89-51(8)102)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-69,72,85,99H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,83,104)(H,86,111)(H,87,100)(H,88,101)(H,89,102)(H,90,105)(H,91,107)(H,92,106)(H,93,109)(H,94,108)(H,95,112)(H,96,103)(H,97,110)/t48-,62+,63+,64-,65-,66-,67+,68-,69-,72+/m1/s1
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PC sid
UniChem
Article
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n/an/a 0.0560n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060807
PNG
(CHEMBL216519 | [L-3Pal3]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H102ClN15O14/c1-46(2)37-63(72(102)89-62(18-11-12-35-84-47(3)4)80(110)96-36-14-19-70(96)79(109)85-48(5)71(82)101)90-74(104)66(40-53-23-30-60(31-24-53)86-49(6)98)92-76(106)67(41-54-25-32-61(33-26-54)87-50(7)99)94-78(108)69(45-97)95-77(107)68(43-56-15-13-34-83-44-56)93-75(105)65(39-52-21-28-59(81)29-22-52)91-73(103)64(88-51(8)100)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-70,84,97H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,82,101)(H,85,109)(H,86,98)(H,87,99)(H,88,100)(H,89,102)(H,90,104)(H,91,103)(H,92,106)(H,93,105)(H,94,108)(H,95,107)/t48-,62+,63+,64-,65-,66-,67+,68+,69+,70-/m1/s1
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PC sid
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n/an/a 0.230n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060786
PNG
(CHEMBL415351 | [Ac-D2Nal1,D4Cpa2,D3Pal3,4Aph5(Ac),...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H102ClN15O14/c1-46(2)37-63(72(102)89-62(18-11-12-35-84-47(3)4)80(110)96-36-14-19-70(96)79(109)85-48(5)71(82)101)90-74(104)66(40-53-23-30-60(31-24-53)86-49(6)98)92-76(106)67(41-54-25-32-61(33-26-54)87-50(7)99)94-78(108)69(45-97)95-77(107)68(43-56-15-13-34-83-44-56)93-75(105)65(39-52-21-28-59(81)29-22-52)91-73(103)64(88-51(8)100)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-70,84,97H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,82,101)(H,85,109)(H,86,98)(H,87,99)(H,88,100)(H,89,102)(H,90,104)(H,91,103)(H,92,106)(H,93,105)(H,94,108)(H,95,107)/t48-,62+,63+,64-,65-,66-,67+,68-,69+,70-/m1/s1
KEGG

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PC sid
UniChem
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n/an/a 0.300n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060776
PNG
(CHEMBL262825 | [D/LAgl (4-hydroxybenzoyl)5]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)NC(=O)c1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C78H98ClN15O15/c1-44(2)36-60(70(101)86-59(17-10-11-34-82-45(3)4)78(109)94-35-13-18-66(94)76(107)83-46(5)67(80)99)87-73(104)63(39-50-22-29-57(30-23-50)84-47(6)96)90-77(108)68(92-69(100)54-25-31-58(98)32-26-54)93-75(106)65(43-95)91-74(105)64(41-52-14-12-33-81-42-52)89-72(103)62(38-49-20-27-56(79)28-21-49)88-71(102)61(85-48(7)97)40-51-19-24-53-15-8-9-16-55(53)37-51/h8-9,12,14-16,19-33,37,42,44-46,59-66,68,82,95,98H,10-11,13,17-18,34-36,38-41,43H2,1-7H3,(H2,80,99)(H,83,107)(H,84,96)(H,85,97)(H,86,101)(H,87,104)(H,88,102)(H,89,103)(H,90,108)(H,91,105)(H,92,100)(H,93,106)/t46-,59+,60+,61-,62-,63-,64-,65+,66-,68-/m1/s1
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PC sid
UniChem
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060779
PNG
(CHEMBL407316 | [L or DAgl (hydroxyacetic acid)4]ac...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](NC(=O)CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)37-63(73(105)90-62(18-11-12-35-85-47(3)4)81(113)98-36-14-19-69(98)79(111)86-48(5)71(83)104)91-75(107)66(40-53-23-30-60(31-24-53)87-49(6)100)93-77(109)67(41-54-25-32-61(33-26-54)88-50(7)101)95-80(112)72(96-70(103)45-99)97-78(110)68(43-56-15-13-34-84-44-56)94-76(108)65(39-52-21-28-59(82)29-22-52)92-74(106)64(89-51(8)102)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-69,72,85,99H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,83,104)(H,86,111)(H,87,100)(H,88,101)(H,89,102)(H,90,105)(H,91,107)(H,92,106)(H,93,109)(H,94,108)(H,95,112)(H,96,103)(H,97,110)/t48-,62+,63+,64-,65-,66-,67+,68-,69-,72-/m1/s1
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060811
PNG
(CHEMBL412472 | [Ac-D or LAgl (Me,2-naphthoyl)1]acy...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(C)=O)N(C)C(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)38-63(72(104)90-62(19-12-13-36-85-47(3)4)81(113)98-37-15-20-69(98)78(110)86-48(5)70(83)103)91-73(105)64(40-53-23-31-60(32-24-53)87-49(6)100)92-74(106)65(41-54-25-33-61(34-26-54)88-50(7)101)94-77(109)68(45-99)96-76(108)67(42-55-16-14-35-84-44-55)93-75(107)66(39-52-21-29-59(82)30-22-52)95-79(111)71(89-51(8)102)97(9)80(112)58-28-27-56-17-10-11-18-57(56)43-58/h10-11,14,16-18,21-35,43-44,46-48,62-69,71,85,99H,12-13,15,19-20,36-42,45H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,105)(H,92,106)(H,93,107)(H,94,109)(H,95,111)(H,96,108)/t48-,62+,63+,64-,65+,66-,67-,68+,69-,71+/m1/s1
KEGG

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PC cid
PC sid
UniChem
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PubMed
n/an/a 0.300n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060775
PNG
(CHEMBL413752 | [L-Ala10]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C80H102ClN15O14/c1-46(2)37-63(72(102)89-62(18-11-12-35-84-47(3)4)80(110)96-36-14-19-70(96)79(109)85-48(5)71(82)101)90-74(104)66(40-53-23-30-60(31-24-53)86-49(6)98)92-76(106)67(41-54-25-32-61(33-26-54)87-50(7)99)94-78(108)69(45-97)95-77(107)68(43-56-15-13-34-83-44-56)93-75(105)65(39-52-21-28-59(81)29-22-52)91-73(103)64(88-51(8)100)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-70,84,97H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,82,101)(H,85,109)(H,86,98)(H,87,99)(H,88,100)(H,89,102)(H,90,104)(H,91,103)(H,92,106)(H,93,105)(H,94,108)(H,95,107)/t48-,62-,63-,64+,65+,66+,67-,68+,69-,70+/m0/s1
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n/an/a 0.380n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060778
PNG
(CHEMBL407681 | [D/LAgl (Me, 4-(acetylamino)benzoyl...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C(=O)c1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)38-63(72(104)90-62(19-12-13-36-85-47(3)4)81(113)98-37-15-20-69(98)78(110)86-48(5)70(83)103)91-75(107)66(41-53-24-31-60(32-25-53)87-49(6)100)94-79(111)71(97(9)80(112)57-27-33-61(34-28-57)88-50(7)101)96-77(109)68(45-99)95-76(108)67(43-55-16-14-35-84-44-55)93-74(106)65(40-52-22-29-59(82)30-23-52)92-73(105)64(89-51(8)102)42-54-21-26-56-17-10-11-18-58(56)39-54/h10-11,14,16-18,21-35,39,44,46-48,62-69,71,85,99H,12-13,15,19-20,36-38,40-43,45H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,107)(H,92,105)(H,93,106)(H,94,111)(H,95,108)(H,96,109)/t48-,62+,63+,64-,65-,66-,67-,68+,69-,71-/m1/s1
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n/an/a 0.430n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060794
PNG
(CHEMBL2370593 | [D/LAgl10]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](N)C(N)=O
Show InChI InChI=1S/C79H101ClN16O14/c1-45(2)36-61(71(102)88-60(17-10-11-34-84-46(3)4)79(110)96-35-13-18-68(96)78(109)95-69(81)70(82)101)89-73(104)64(39-51-22-29-58(30-23-51)85-47(5)98)91-75(106)65(40-52-24-31-59(32-25-52)86-48(6)99)93-77(108)67(44-97)94-76(107)66(42-54-14-12-33-83-43-54)92-74(105)63(38-50-20-27-57(80)28-21-50)90-72(103)62(87-49(7)100)41-53-19-26-55-15-8-9-16-56(55)37-53/h8-9,12,14-16,19-33,37,43,45-46,60-69,84,97H,10-11,13,17-18,34-36,38-42,44,81H2,1-7H3,(H2,82,101)(H,85,98)(H,86,99)(H,87,100)(H,88,102)(H,89,104)(H,90,103)(H,91,106)(H,92,105)(H,93,108)(H,94,107)(H,95,109)/t60-,61-,62+,63+,64+,65-,66+,67-,68+,69-/m0/s1
KEGG

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.480n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060795
PNG
(CHEMBL2370590 | [D or LAgl (Me, isopropyl--Ala)8]a...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](N(C)C(=O)CCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)36-61(77(109)95-71(96(9)69(102)32-34-84-46(3)4)80(112)97-35-13-17-68(97)79(111)85-47(5)70(82)103)89-73(105)64(39-52-21-28-59(29-22-52)86-48(6)99)91-75(107)65(40-53-23-30-60(31-24-53)87-49(7)100)93-78(110)67(44-98)94-76(108)66(42-55-14-12-33-83-43-55)92-74(106)63(38-51-19-26-58(81)27-20-51)90-72(104)62(88-50(8)101)41-54-18-25-56-15-10-11-16-57(56)37-54/h10-12,14-16,18-31,33,37,43,45-47,61-68,71,84,98H,13,17,32,34-36,38-42,44H2,1-9H3,(H2,82,103)(H,85,111)(H,86,99)(H,87,100)(H,88,101)(H,89,105)(H,90,104)(H,91,107)(H,92,106)(H,93,110)(H,94,108)(H,95,109)/t47-,61+,62-,63-,64-,65+,66-,67+,68-,71+/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060806
PNG
(CHEMBL263358 | [D/LAgl (4-(acetylamino)benzoyl)5]a...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)NC(=O)c1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)37-62(72(104)89-61(18-11-12-35-84-46(3)4)80(112)97-36-14-19-68(97)78(110)85-47(5)69(82)102)90-75(107)65(40-52-23-30-59(31-24-52)86-48(6)99)93-79(111)70(95-71(103)56-26-32-60(33-27-56)87-49(7)100)96-77(109)67(44-98)94-76(108)66(42-54-15-13-34-83-43-54)92-74(106)64(39-51-21-28-58(81)29-22-51)91-73(105)63(88-50(8)101)41-53-20-25-55-16-9-10-17-57(55)38-53/h9-10,13,15-17,20-34,38,43,45-47,61-68,70,84,98H,11-12,14,18-19,35-37,39-42,44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,107)(H,91,105)(H,92,106)(H,93,111)(H,94,108)(H,95,103)(H,96,109)/t47-,61+,62+,63-,64-,65-,66-,67+,68-,70+/m1/s1
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n/an/a 0.510n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060791
PNG
(CHEMBL2370592 | [D/LAgl (Me/isobutyryl)7]acyline)
Show SMILES CC(C)CC(=O)N(C)[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C82H105ClN16O15/c1-47(2)38-71(104)98(9)73(81(113)91-63(19-12-13-36-86-48(3)4)82(114)99-37-15-20-70(99)80(112)87-49(5)72(84)105)97-78(110)67(42-55-26-33-62(34-27-55)89-51(7)102)93-76(108)66(41-54-24-31-61(32-25-54)88-50(6)101)95-79(111)69(46-100)96-77(109)68(44-57-16-14-35-85-45-57)94-75(107)65(40-53-22-29-60(83)30-23-53)92-74(106)64(90-52(8)103)43-56-21-28-58-17-10-11-18-59(58)39-56/h10-11,14,16-18,21-35,39,45,47-49,63-70,73,86,100H,12-13,15,19-20,36-38,40-44,46H2,1-9H3,(H2,84,105)(H,87,112)(H,88,101)(H,89,102)(H,90,103)(H,91,113)(H,92,106)(H,93,108)(H,94,107)(H,95,111)(H,96,109)(H,97,110)/t49-,63+,64-,65-,66+,67-,68-,69+,70-,73+/m1/s1
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n/an/a 0.530n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060792
PNG
(CHEMBL407615 | [D or LAgl (formyl)10]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](NC=O)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-46(2)36-62(72(104)89-61(17-10-11-34-84-47(3)4)80(112)97-35-13-18-69(97)79(111)96-71(70(82)103)85-45-99)90-74(106)65(39-52-22-29-59(30-23-52)86-48(5)100)92-76(108)66(40-53-24-31-60(32-25-53)87-49(6)101)94-78(110)68(44-98)95-77(109)67(42-55-14-12-33-83-43-55)93-75(107)64(38-51-20-27-58(81)28-21-51)91-73(105)63(88-50(7)102)41-54-19-26-56-15-8-9-16-57(56)37-54/h8-9,12,14-16,19-33,37,43,45-47,61-69,71,84,98H,10-11,13,17-18,34-36,38-42,44H2,1-7H3,(H2,82,103)(H,85,99)(H,86,100)(H,87,101)(H,88,102)(H,89,104)(H,90,106)(H,91,105)(H,92,108)(H,93,107)(H,94,110)(H,95,109)(H,96,111)/t61-,62-,63+,64+,65+,66-,67+,68-,69+,71-/m0/s1
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n/an/a 0.590n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060809
PNG
(CHEMBL267642 | [L or DAgl (formyl)10]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](NC=O)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-46(2)36-62(72(104)89-61(17-10-11-34-84-47(3)4)80(112)97-35-13-18-69(97)79(111)96-71(70(82)103)85-45-99)90-74(106)65(39-52-22-29-59(30-23-52)86-48(5)100)92-76(108)66(40-53-24-31-60(32-25-53)87-49(6)101)94-78(110)68(44-98)95-77(109)67(42-55-14-12-33-83-43-55)93-75(107)64(38-51-20-27-58(81)28-21-51)91-73(105)63(88-50(7)102)41-54-19-26-56-15-8-9-16-57(56)37-54/h8-9,12,14-16,19-33,37,43,45-47,61-69,71,84,98H,10-11,13,17-18,34-36,38-42,44H2,1-7H3,(H2,82,103)(H,85,99)(H,86,100)(H,87,101)(H,88,102)(H,89,104)(H,90,106)(H,91,105)(H,92,108)(H,93,107)(H,94,110)(H,95,109)(H,96,111)/t61-,62-,63+,64+,65+,66-,67+,68-,69+,71+/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060773
PNG
(CHEMBL262842 | [L or DAgl (nicotinoyl)3]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)NC(=O)c1cccnc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)37-62(72(104)89-61(18-11-12-35-84-46(3)4)80(112)97-36-14-19-68(97)78(110)85-47(5)69(82)102)90-74(106)64(40-52-23-30-59(31-24-52)86-48(6)99)91-75(107)65(41-53-25-32-60(33-26-53)87-49(7)100)93-77(109)67(44-98)94-79(111)70(95-71(103)57-17-13-34-83-43-57)96-76(108)66(39-51-21-28-58(81)29-22-51)92-73(105)63(88-50(8)101)42-54-20-27-55-15-9-10-16-56(55)38-54/h9-10,13,15-17,20-34,38,43,45-47,61-68,70,84,98H,11-12,14,18-19,35-37,39-42,44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,106)(H,91,107)(H,92,105)(H,93,109)(H,94,111)(H,95,103)(H,96,108)/t47-,61+,62+,63-,64-,65+,66-,67+,68-,70+/m1/s1
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n/an/a 0.630n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060770
PNG
(CHEMBL407058 | [D or LAgl (formyl)4]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@@H](NC=O)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O14/c1-46(2)37-63(72(103)90-62(18-11-12-35-84-47(3)4)80(111)97-36-14-19-69(97)78(109)86-48(5)70(82)102)91-74(105)66(40-53-23-30-60(31-24-53)87-49(6)99)93-76(107)67(41-54-25-32-61(33-26-54)88-50(7)100)95-79(110)71(85-45-98)96-77(108)68(43-56-15-13-34-83-44-56)94-75(106)65(39-52-21-28-59(81)29-22-52)92-73(104)64(89-51(8)101)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44-48,62-69,71,84H,11-12,14,18-19,35-37,39-43H2,1-8H3,(H2,82,102)(H,85,98)(H,86,109)(H,87,99)(H,88,100)(H,89,101)(H,90,103)(H,91,105)(H,92,104)(H,93,107)(H,94,106)(H,95,110)(H,96,108)/t48-,62+,63+,64-,65-,66-,67+,68-,69-,71+/m1/s1
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n/an/a 0.630n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060802
PNG
(CHEMBL414558 | [Ac-L-2Nal1]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H102ClN15O14/c1-46(2)37-63(72(102)89-62(18-11-12-35-84-47(3)4)80(110)96-36-14-19-70(96)79(109)85-48(5)71(82)101)90-74(104)66(40-53-23-30-60(31-24-53)86-49(6)98)92-76(106)67(41-54-25-32-61(33-26-54)87-50(7)99)94-78(108)69(45-97)95-77(107)68(43-56-15-13-34-83-44-56)93-75(105)65(39-52-21-28-59(81)29-22-52)91-73(103)64(88-51(8)100)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-70,84,97H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,82,101)(H,85,109)(H,86,98)(H,87,99)(H,88,100)(H,89,102)(H,90,104)(H,91,103)(H,92,106)(H,93,105)(H,94,108)(H,95,107)/t48-,62+,63+,64+,65-,66-,67+,68-,69+,70-/m1/s1
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n/an/a 0.640n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060774
PNG
(CHEMBL2370594 | [D/LAgl (Me,formyl)10]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](N(C)C=O)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-47(2)37-63(73(105)89-62(18-11-12-35-85-48(3)4)81(113)98-36-14-19-70(98)80(112)96-72(71(83)104)97(8)46-100)90-75(107)66(40-53-23-30-60(31-24-53)86-49(5)101)92-77(109)67(41-54-25-32-61(33-26-54)87-50(6)102)94-79(111)69(45-99)95-78(110)68(43-56-15-13-34-84-44-56)93-76(108)65(39-52-21-28-59(82)29-22-52)91-74(106)64(88-51(7)103)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-70,72,85,99H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,83,104)(H,86,101)(H,87,102)(H,88,103)(H,89,105)(H,90,107)(H,91,106)(H,92,109)(H,93,108)(H,94,111)(H,95,110)(H,96,112)/t62-,63-,64+,65+,66+,67-,68+,69-,70+,72-/m0/s1
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n/an/a 0.670n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060787
PNG
(CHEMBL414469 | [D/LAgl (guanidinoacetyl)8]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)NC(NC(=O)CNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C76H93ClN18O15/c1-41(2)31-56(72(107)94-66(93-64(100)39-82-76(79)80)75(110)95-30-10-14-63(95)74(109)83-42(3)65(78)101)87-68(103)59(34-47-18-25-54(26-19-47)84-43(4)97)89-70(105)60(35-48-20-27-55(28-21-48)85-44(5)98)91-73(108)62(40-96)92-71(106)61(37-50-11-9-29-81-38-50)90-69(104)58(33-46-16-23-53(77)24-17-46)88-67(102)57(86-45(6)99)36-49-15-22-51-12-7-8-13-52(51)32-49/h7-9,11-13,15-29,32,38,41-42,56-63,66,96H,10,14,30-31,33-37,39-40H2,1-6H3,(H2,78,101)(H,83,109)(H,84,97)(H,85,98)(H,86,99)(H,87,103)(H,88,102)(H,89,105)(H,90,104)(H,91,108)(H,92,106)(H,93,100)(H,94,107)(H4,79,80,82)/t42-,56+,57-,58-,59-,60+,61-,62+,63-,66?/m1/s1
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UniChem
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n/an/a 0.740n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060801
PNG
(CHEMBL414468 | [D or LAgl (nicotinoyl)3]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)NC(=O)c1cccnc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)37-62(72(104)89-61(18-11-12-35-84-46(3)4)80(112)97-36-14-19-68(97)78(110)85-47(5)69(82)102)90-74(106)64(40-52-23-30-59(31-24-52)86-48(6)99)91-75(107)65(41-53-25-32-60(33-26-53)87-49(7)100)93-77(109)67(44-98)94-79(111)70(95-71(103)57-17-13-34-83-43-57)96-76(108)66(39-51-21-28-58(81)29-22-51)92-73(105)63(88-50(8)101)42-54-20-27-55-15-9-10-16-56(55)38-54/h9-10,13,15-17,20-34,38,43,45-47,61-68,70,84,98H,11-12,14,18-19,35-37,39-42,44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,106)(H,91,107)(H,92,105)(H,93,109)(H,94,111)(H,95,103)(H,96,108)/t47-,61+,62+,63-,64-,65+,66-,67+,68-,70-/m1/s1
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n/an/a 0.760n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060805
PNG
(CHEMBL410798 | [L or LAgl (formyl)4]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](NC=O)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O14/c1-46(2)37-63(72(103)90-62(18-11-12-35-84-47(3)4)80(111)97-36-14-19-69(97)78(109)86-48(5)70(82)102)91-74(105)66(40-53-23-30-60(31-24-53)87-49(6)99)93-76(107)67(41-54-25-32-61(33-26-54)88-50(7)100)95-79(110)71(85-45-98)96-77(108)68(43-56-15-13-34-83-44-56)94-75(106)65(39-52-21-28-59(81)29-22-52)92-73(104)64(89-51(8)101)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44-48,62-69,71,84H,11-12,14,18-19,35-37,39-43H2,1-8H3,(H2,82,102)(H,85,98)(H,86,109)(H,87,99)(H,88,100)(H,89,101)(H,90,103)(H,91,105)(H,92,104)(H,93,107)(H,94,106)(H,95,110)(H,96,108)/t48-,62+,63+,64-,65-,66-,67+,68-,69-,71-/m1/s1
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n/an/a 0.840n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060808
PNG
(CHEMBL436683 | [Ac-L or DAgl (2-naphthoyl)1]acylin...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](NC(C)=O)NC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)37-62(72(104)89-61(18-11-12-35-84-46(3)4)80(112)97-36-14-19-68(97)78(110)85-47(5)69(82)102)90-73(105)63(39-52-22-30-59(31-23-52)86-48(6)99)91-74(106)64(40-53-24-32-60(33-25-53)87-49(7)100)93-77(109)67(44-98)95-76(108)66(41-54-15-13-34-83-43-54)92-75(107)65(38-51-20-28-58(81)29-21-51)94-79(111)70(88-50(8)101)96-71(103)57-27-26-55-16-9-10-17-56(55)42-57/h9-10,13,15-17,20-34,42-43,45-47,61-68,70,84,98H,11-12,14,18-19,35-41,44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,105)(H,91,106)(H,92,107)(H,93,109)(H,94,111)(H,95,108)(H,96,103)/t47-,61+,62+,63-,64+,65-,66-,67+,68-,70-/m1/s1
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n/an/a 0.880n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060789
PNG
(CHEMBL262309 | [D or LAgl (Me,formyl)4]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O14/c1-47(2)38-64(73(104)90-63(19-12-13-36-85-48(3)4)81(112)98-37-15-20-70(98)79(110)86-49(5)71(83)103)91-75(106)67(41-54-24-31-61(32-25-54)87-50(6)100)93-77(108)68(42-55-26-33-62(34-27-55)88-51(7)101)95-80(111)72(97(9)46-99)96-78(109)69(44-57-16-14-35-84-45-57)94-76(107)66(40-53-22-29-60(82)30-23-53)92-74(105)65(89-52(8)102)43-56-21-28-58-17-10-11-18-59(58)39-56/h10-11,14,16-18,21-35,39,45-49,63-70,72,85H,12-13,15,19-20,36-38,40-44H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,106)(H,92,105)(H,93,108)(H,94,107)(H,95,111)(H,96,109)/t49-,63+,64+,65-,66-,67-,68+,69-,70-,72-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060799
PNG
(CHEMBL2370589 | [D/LAgl (Me)10]acyline)
Show SMILES CN[C@@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C80H103ClN16O14/c1-46(2)37-62(72(103)89-61(18-11-12-35-85-47(3)4)80(111)97-36-14-19-69(97)79(110)96-71(83-8)70(82)102)90-74(105)65(40-52-23-30-59(31-24-52)86-48(5)99)92-76(107)66(41-53-25-32-60(33-26-53)87-49(6)100)94-78(109)68(45-98)95-77(108)67(43-55-15-13-34-84-44-55)93-75(106)64(39-51-21-28-58(81)29-22-51)91-73(104)63(88-50(7)101)42-54-20-27-56-16-9-10-17-57(56)38-54/h9-10,13,15-17,20-34,38,44,46-47,61-69,71,83,85,98H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,82,102)(H,86,99)(H,87,100)(H,88,101)(H,89,103)(H,90,105)(H,91,104)(H,92,107)(H,93,106)(H,94,109)(H,95,108)(H,96,110)/t61-,62-,63+,64+,65+,66-,67+,68-,69+,71-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060777
PNG
(CHEMBL429902 | [L or DAgl (Me,4-Cl-benzoyl)2]acyli...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)38-63(72(104)90-62(19-12-13-36-85-47(3)4)81(113)98-37-15-20-69(98)78(110)86-48(5)70(83)103)91-73(105)65(40-52-22-31-60(32-23-52)87-49(6)100)92-74(106)66(41-53-24-33-61(34-25-53)88-50(7)101)93-77(109)68(45-99)95-75(107)67(43-55-16-14-35-84-44-55)94-79(111)71(97(9)80(112)57-27-29-59(82)30-28-57)96-76(108)64(89-51(8)102)42-54-21-26-56-17-10-11-18-58(56)39-54/h10-11,14,16-18,21-35,39,44,46-48,62-69,71,85,99H,12-13,15,19-20,36-38,40-43,45H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,105)(H,92,106)(H,93,109)(H,94,111)(H,95,107)(H,96,108)/t48-,62+,63+,64-,65-,66+,67-,68+,69-,71-/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060803
PNG
(CHEMBL436897 | [L or DAgl (isonicotinoyl)3]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)NC(=O)c1ccncc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)38-62(72(104)89-61(16-11-12-34-84-46(3)4)80(112)97-37-13-17-68(97)78(110)85-47(5)69(82)102)90-74(106)64(41-52-21-28-59(29-22-52)86-48(6)99)91-75(107)65(42-53-23-30-60(31-24-53)87-49(7)100)93-77(109)67(44-98)94-79(111)70(95-71(103)56-32-35-83-36-33-56)96-76(108)66(40-51-19-26-58(81)27-20-51)92-73(105)63(88-50(8)101)43-54-18-25-55-14-9-10-15-57(55)39-54/h9-10,14-15,18-33,35-36,39,45-47,61-68,70,84,98H,11-13,16-17,34,37-38,40-44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,106)(H,91,107)(H,92,105)(H,93,109)(H,94,111)(H,95,103)(H,96,108)/t47-,61+,62+,63-,64-,65+,66-,67+,68-,70+/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060800
PNG
(CHEMBL405736 | [D/LAgl (Me,Ac)7]acyline)
Show SMILES CC(C)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C(C)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C79H99ClN16O15/c1-45(2)83-35-12-11-18-61(79(111)96-36-14-19-68(96)77(109)84-46(3)69(81)102)88-78(110)70(95(8)50(7)101)94-75(107)65(40-53-25-32-60(33-26-53)86-48(5)99)90-73(105)64(39-52-23-30-59(31-24-52)85-47(4)98)92-76(108)67(44-97)93-74(106)66(42-55-15-13-34-82-43-55)91-72(104)63(38-51-21-28-58(80)29-22-51)89-71(103)62(87-49(6)100)41-54-20-27-56-16-9-10-17-57(56)37-54/h9-10,13,15-17,20-34,37,43,45-46,61-68,70,83,97H,11-12,14,18-19,35-36,38-42,44H2,1-8H3,(H2,81,102)(H,84,109)(H,85,98)(H,86,99)(H,87,100)(H,88,110)(H,89,103)(H,90,105)(H,91,104)(H,92,108)(H,93,106)(H,94,107)/t46-,61+,62-,63-,64+,65-,66-,67+,68-,70+/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060797
PNG
(CHEMBL410818 | [L or DAgl (Me, 4-(acetylamino)benz...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C(=O)c1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)38-63(72(104)90-62(19-12-13-36-85-47(3)4)81(113)98-37-15-20-69(98)78(110)86-48(5)70(83)103)94-79(111)71(97(9)80(112)57-27-33-61(34-28-57)88-50(7)101)96-76(108)66(41-53-24-31-60(32-25-53)87-49(6)100)93-77(109)68(45-99)95-75(107)67(43-55-16-14-35-84-44-55)92-74(106)65(40-52-22-29-59(82)30-23-52)91-73(105)64(89-51(8)102)42-54-21-26-56-17-10-11-18-58(56)39-54/h10-11,14,16-18,21-35,39,44,46-48,62-69,71,85,99H,12-13,15,19-20,36-38,40-43,45H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,105)(H,92,106)(H,93,109)(H,94,111)(H,95,107)(H,96,108)/t48-,62+,63+,64-,65-,66+,67-,68+,69-,71-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290345
PNG
(7-(3,4-Difluoro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccc(F)c(F)c3)c12
Show InChI InChI=1S/C21H17F3N2O/c22-15-5-7-16(8-6-15)26-21-14(2-1-3-17(21)20(12-27)25-26)10-13-4-9-18(23)19(24)11-13/h4-9,11-12,14H,1-3,10H2
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060804
PNG
(CHEMBL269097 | [D/LAgl (isobutyryl)7]acyline)
Show SMILES CC(C)CC(=O)N[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)37-70(103)96-72(80(112)90-62(18-11-12-35-85-47(3)4)81(113)98-36-14-19-69(98)79(111)86-48(5)71(83)104)97-77(109)66(41-54-25-32-61(33-26-54)88-50(7)101)92-75(107)65(40-53-23-30-60(31-24-53)87-49(6)100)94-78(110)68(45-99)95-76(108)67(43-56-15-13-34-84-44-56)93-74(106)64(39-52-21-28-59(82)29-22-52)91-73(105)63(89-51(8)102)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-69,72,85,99H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,83,104)(H,86,111)(H,87,100)(H,88,101)(H,89,102)(H,90,112)(H,91,105)(H,92,107)(H,93,106)(H,94,110)(H,95,108)(H,96,103)(H,97,109)/t48-,62+,63-,64-,65+,66-,67-,68+,69-,72-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060793
PNG
(CHEMBL410799 | [Dpr (isobutyryl)7]acyline)
Show SMILES CC(C)CC(=O)N[C@@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)37-70(103)96-72(80(112)90-62(18-11-12-35-85-47(3)4)81(113)98-36-14-19-69(98)79(111)86-48(5)71(83)104)97-77(109)66(41-54-25-32-61(33-26-54)88-50(7)101)92-75(107)65(40-53-23-30-60(31-24-53)87-49(6)100)94-78(110)68(45-99)95-76(108)67(43-56-15-13-34-84-44-56)93-74(106)64(39-52-21-28-59(82)29-22-52)91-73(105)63(89-51(8)102)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-69,72,85,99H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,83,104)(H,86,111)(H,87,100)(H,88,101)(H,89,102)(H,90,112)(H,91,105)(H,92,107)(H,93,106)(H,94,110)(H,95,108)(H,96,103)(H,97,109)/t48-,62+,63-,64-,65+,66-,67-,68+,69-,72+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290353
PNG
(CHEMBL422241 | [1-[1-(4-Fluoro-phenyl)-7-naphthale...)
Show SMILES Fc1ccc(cc1)-n1nc(\C=N\c2ccccc2)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C31H26FN3/c32-25-16-18-27(19-17-25)35-31-24(20-23-10-6-9-22-8-4-5-14-28(22)23)11-7-15-29(31)30(34-35)21-33-26-12-2-1-3-13-26/h1-6,8-10,12-14,16-19,21,24H,7,11,15,20H2/b33-21+
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060782
PNG
(CHEMBL411144 | [L or DAgl (Me, isopropyl--Ala)8]ac...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](N(C)C(=O)CCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)36-61(77(109)95-71(96(9)69(102)32-34-84-46(3)4)80(112)97-35-13-17-68(97)79(111)85-47(5)70(82)103)89-73(105)64(39-52-21-28-59(29-22-52)86-48(6)99)91-75(107)65(40-53-23-30-60(31-24-53)87-49(7)100)93-78(110)67(44-98)94-76(108)66(42-55-14-12-33-83-43-55)92-74(106)63(38-51-19-26-58(81)27-20-51)90-72(104)62(88-50(8)101)41-54-18-25-56-15-10-11-16-57(56)37-54/h10-12,14-16,18-31,33,37,43,45-47,61-68,71,84,98H,13,17,32,34-36,38-42,44H2,1-9H3,(H2,82,103)(H,85,111)(H,86,99)(H,87,100)(H,88,101)(H,89,105)(H,90,104)(H,91,107)(H,92,106)(H,93,110)(H,94,108)(H,95,109)/t47-,61+,62-,63-,64-,65+,66-,67+,68-,71-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290364
PNG
(7-Benzyl-1-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccccc3)c12
Show InChI InChI=1S/C21H19FN2O/c22-17-9-11-18(12-10-17)24-21-16(13-15-5-2-1-3-6-15)7-4-8-19(21)20(14-25)23-24/h1-3,5-6,9-12,14,16H,4,7-8,13H2
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n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060796
PNG
(CHEMBL413456 | [Ac-D or LAgl (2-naphthoyl)1]acylin...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(C)=O)NC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)37-62(72(104)89-61(18-11-12-35-84-46(3)4)80(112)97-36-14-19-68(97)78(110)85-47(5)69(82)102)90-73(105)63(39-52-22-30-59(31-23-52)86-48(6)99)91-74(106)64(40-53-24-32-60(33-25-53)87-49(7)100)93-77(109)67(44-98)95-76(108)66(41-54-15-13-34-83-43-54)92-75(107)65(38-51-20-28-58(81)29-21-51)94-79(111)70(88-50(8)101)96-71(103)57-27-26-55-16-9-10-17-56(55)42-57/h9-10,13,15-17,20-34,42-43,45-47,61-68,70,84,98H,11-12,14,18-19,35-41,44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,105)(H,91,106)(H,92,107)(H,93,109)(H,94,111)(H,95,108)(H,96,103)/t47-,61+,62+,63-,64+,65-,66-,67+,68-,70+/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290359
PNG
(1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C25H21FN2O/c26-20-11-13-21(14-12-20)28-25-19(8-4-10-23(25)24(16-29)27-28)15-18-7-3-6-17-5-1-2-9-22(17)18/h1-3,5-7,9,11-14,16,19H,4,8,10,15H2
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n/an/a 3.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060790
PNG
(CHEMBL444903 | D/LAgl (Ac)7]acyline)
Show SMILES CC(C)NCCCC[C@H](NC(=O)[C@H](NC(C)=O)NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C78H97ClN16O15/c1-44(2)82-34-11-10-17-60(78(110)95-35-13-18-67(95)76(108)83-45(3)68(80)101)88-77(109)69(87-49(7)100)94-74(106)64(39-52-24-31-59(32-25-52)85-47(5)98)90-72(104)63(38-51-22-29-58(30-23-51)84-46(4)97)92-75(107)66(43-96)93-73(105)65(41-54-14-12-33-81-42-54)91-71(103)62(37-50-20-27-57(79)28-21-50)89-70(102)61(86-48(6)99)40-53-19-26-55-15-8-9-16-56(55)36-53/h8-9,12,14-16,19-33,36,42,44-45,60-67,69,82,96H,10-11,13,17-18,34-35,37-41,43H2,1-7H3,(H2,80,101)(H,83,108)(H,84,97)(H,85,98)(H,86,99)(H,87,100)(H,88,109)(H,89,102)(H,90,104)(H,91,103)(H,92,107)(H,93,105)(H,94,106)/t45-,60+,61-,62-,63+,64-,65-,66+,67-,69-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060810
PNG
(CHEMBL408335 | [D or LAgl (Me, 4-(acetylamino)benz...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C(=O)c1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)38-63(72(104)90-62(19-12-13-36-85-47(3)4)81(113)98-37-15-20-69(98)78(110)86-48(5)70(83)103)94-79(111)71(97(9)80(112)57-27-33-61(34-28-57)88-50(7)101)96-76(108)66(41-53-24-31-60(32-25-53)87-49(6)100)93-77(109)68(45-99)95-75(107)67(43-55-16-14-35-84-44-55)92-74(106)65(40-52-22-29-59(82)30-23-52)91-73(105)64(89-51(8)102)42-54-21-26-56-17-10-11-18-58(56)39-54/h10-11,14,16-18,21-35,39,44,46-48,62-69,71,85,99H,12-13,15,19-20,36-38,40-43,45H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,105)(H,92,106)(H,93,109)(H,94,111)(H,95,107)(H,96,108)/t48-,62+,63+,64-,65-,66+,67-,68+,69-,71+/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290336
PNG
(Acetic acid acetoxy-[1-(4-fluoro-phenyl)-7-naphtha...)
Show SMILES CC(=O)OC(OC(C)=O)c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H27FN2O4/c1-18(33)35-29(36-19(2)34)27-26-12-6-10-22(17-21-9-5-8-20-7-3-4-11-25(20)21)28(26)32(31-27)24-15-13-23(30)14-16-24/h3-5,7-9,11,13-16,22,29H,6,10,12,17H2,1-2H3
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n/an/a 5.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060781
PNG
(CHEMBL263629 | [L or DAgl (Me,formyl)4]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O14/c1-47(2)38-64(73(104)90-63(19-12-13-36-85-48(3)4)81(112)98-37-15-20-70(98)79(110)86-49(5)71(83)103)91-75(106)67(41-54-24-31-61(32-25-54)87-50(6)100)93-77(108)68(42-55-26-33-62(34-27-55)88-51(7)101)95-80(111)72(97(9)46-99)96-78(109)69(44-57-16-14-35-84-45-57)94-76(107)66(40-53-22-29-60(82)30-23-53)92-74(105)65(89-52(8)102)43-56-21-28-58-17-10-11-18-59(58)39-56/h10-11,14,16-18,21-35,39,45-49,63-70,72,85H,12-13,15,19-20,36-38,40-44H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,106)(H,92,105)(H,93,108)(H,94,107)(H,95,111)(H,96,109)/t49-,63+,64+,65-,66-,67-,68+,69-,70-,72+/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290361
PNG
(7-Naphthalen-1-ylmethyl-1-phenyl-4,5,6,7-tetrahydr...)
Show SMILES O=Cc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccccc1
Show InChI InChI=1S/C25H22N2O/c28-17-24-23-15-7-11-20(25(23)27(26-24)21-12-2-1-3-13-21)16-19-10-6-9-18-8-4-5-14-22(18)19/h1-6,8-10,12-14,17,20H,7,11,15-16H2
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290333
PNG
(7-(4-Fluoro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,7-te...)
Show SMILES Fc1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18F2N2O/c22-16-6-4-14(5-7-16)12-15-2-1-3-19-20(13-26)24-25(21(15)19)18-10-8-17(23)9-11-18/h4-11,13,15H,1-3,12H2
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n/an/a 6.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290356
PNG
(1-(4-Fluoro-phenyl)-7-(4-methyl-benzyl)-4,5,6,7-te...)
Show SMILES Cc1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H21FN2O/c1-15-5-7-16(8-6-15)13-17-3-2-4-20-21(14-26)24-25(22(17)20)19-11-9-18(23)10-12-19/h5-12,14,17H,2-4,13H2,1H3
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n/an/a 7.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290334
PNG
(1-(4-Chloro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES Clc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C25H21ClN2O/c26-20-11-13-21(14-12-20)28-25-19(8-4-10-23(25)24(16-29)27-28)15-18-7-3-6-17-5-1-2-9-22(17)18/h1-3,5-7,9,11-14,16,19H,4,8,10,15H2
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060784
PNG
(CHEMBL265727 | [Ac-L or DAgl (Me,2-naphthoyl)1]acy...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](NC(C)=O)N(C)C(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)38-63(72(104)90-62(19-12-13-36-85-47(3)4)81(113)98-37-15-20-69(98)78(110)86-48(5)70(83)103)91-73(105)64(40-53-23-31-60(32-24-53)87-49(6)100)92-74(106)65(41-54-25-33-61(34-26-54)88-50(7)101)94-77(109)68(45-99)96-76(108)67(42-55-16-14-35-84-44-55)93-75(107)66(39-52-21-29-59(82)30-22-52)95-79(111)71(89-51(8)102)97(9)80(112)58-28-27-56-17-10-11-18-57(56)43-58/h10-11,14,16-18,21-35,43-44,46-48,62-69,71,85,99H,12-13,15,19-20,36-42,45H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,105)(H,92,106)(H,93,107)(H,94,109)(H,95,111)(H,96,108)/t48-,62+,63+,64-,65+,66-,67-,68+,69-,71-/m1/s1
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n/an/a 9.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290362
PNG
(7-(2-Chloro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,7-te...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccccc3Cl)c12
Show InChI InChI=1S/C21H18ClFN2O/c22-19-7-2-1-4-14(19)12-15-5-3-6-18-20(13-26)24-25(21(15)18)17-10-8-16(23)9-11-17/h1-2,4,7-11,13,15H,3,5-6,12H2
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290358
PNG
(7-(4-Chloro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,7-te...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccc(Cl)cc3)c12
Show InChI InChI=1S/C21H18ClFN2O/c22-16-6-4-14(5-7-16)12-15-2-1-3-19-20(13-26)24-25(21(15)19)18-10-8-17(23)9-11-18/h4-11,13,15H,1-3,12H2
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290349
PNG
(1-(4-Methoxy-phenyl)-7-naphthalen-1-ylmethyl-4,5,6...)
Show SMILES COc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C26H24N2O2/c1-30-22-14-12-21(13-15-22)28-26-20(9-5-11-24(26)25(17-29)27-28)16-19-8-4-7-18-6-2-3-10-23(18)19/h2-4,6-8,10,12-15,17,20H,5,9,11,16H2,1H3
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Article
n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290338
PNG
(1-(4-Fluoro-phenyl)-7-(3-methoxy-benzyl)-octahydro...)
Show SMILES COc1cccc(CC2CCCC3C(NN(C23)c2ccc(F)cc2)C=O)c1
Show InChI InChI=1S/C22H25FN2O2/c1-27-19-6-2-4-15(13-19)12-16-5-3-7-20-21(14-26)24-25(22(16)20)18-10-8-17(23)9-11-18/h2,4,6,8-11,13-14,16,20-22,24H,3,5,7,12H2,1H3
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n/an/a 17n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Bioorg Med Chem Lett 7: 2551-2556 (1997)


Article DOI: 10.1016/S0960-894X(97)10016-6
BindingDB Entry DOI: 10.7270/Q2MW2H5C
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060771
PNG
(CHEMBL407193 | [D or LAgl (Me,nicotinoyl)3]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)N(C)C(=O)c1cccnc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)38-63(72(104)90-62(19-12-13-36-85-47(3)4)81(113)98-37-15-20-69(98)78(110)86-48(5)70(83)103)91-74(106)65(41-53-24-31-60(32-25-53)87-49(6)100)92-75(107)66(42-54-26-33-61(34-27-54)88-50(7)101)94-77(109)68(45-99)95-79(111)71(97(9)80(112)58-18-14-35-84-44-58)96-76(108)67(40-52-22-29-59(82)30-23-52)93-73(105)64(89-51(8)102)43-55-21-28-56-16-10-11-17-57(56)39-55/h10-11,14,16-18,21-35,39,44,46-48,62-69,71,85,99H,12-13,15,19-20,36-38,40-43,45H2,1-9H3,(H2,83,103)(H,86,110)(H,87,100)(H,88,101)(H,89,102)(H,90,104)(H,91,106)(H,92,107)(H,93,105)(H,94,109)(H,95,111)(H,96,108)/t48-,62+,63+,64-,65-,66+,67-,68+,69-,71+/m1/s1
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n/an/a 36n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair
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