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Compile Data Set for Download or QSAR

Found 1604 hits with Last Name = 'chen' and Initial = 'v'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318625
PNG
(CHEMBL1083654 | N-Methyl-(3-phenylsulfonyl)-7,8-di...)
Show SMILES CNc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N4O2S/c1-17-15-14(23(21,22)12-7-3-2-4-8-12)16-18-10-11-6-5-9-13(11)20(16)19-15/h2-4,7-8,10H,5-6,9H2,1H3,(H,17,19)
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0.0880n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318626
PNG
(CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...)
Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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0.112n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50358778
PNG
(CHEMBL1922616)
Show SMILES CNc1nn2c(N)c(Cl)c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14ClN5O2S/c1-8-10(15)12(16)20-14(18-8)11(13(17-2)19-20)23(21,22)9-6-4-3-5-7-9/h3-7H,16H2,1-2H3,(H,17,19)
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0.140n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation


J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417934
PNG
(CHEMBL1668590 | US8829009, 1.1(7))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H15ClN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
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0.186n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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0.200n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318627
PNG
(CHEMBL1083075 | N,5-Dimethyl-3-(phenylsulfonyl)-7,...)
Show SMILES CNc1nn2c3CCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-11-13-9-6-10-14(13)21-17(19-11)15(16(18-2)20-21)24(22,23)12-7-4-3-5-8-12/h3-5,7-8H,6,9-10H2,1-2H3,(H,18,20)
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0.202n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318633
PNG
(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Show SMILES O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
Show InChI InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
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0.234n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to 5HT6 receptor


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417915
PNG
(CHEMBL1668586 | US8618114, 1.2.3(1))
Show SMILES CNc1nn2c(C)ccnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-16-14-12(13(15-2)17-18(10)14)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
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0.240n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318624
PNG
(CHEMBL1082762 | N,9-Dimethyl-3-(phenylsulfonyl)-5,...)
Show SMILES CNc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c1-12-14-10-6-7-11-15(14)20-18-16(17(19-2)21-22(12)18)25(23,24)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3,(H,19,21)
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0.256n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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0.257n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318626
PNG
(CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...)
Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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0.259n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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0.260n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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0.260n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation


J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417916
PNG
(CHEMBL1668564 | US8618114, 1.2.5(1))
Show SMILES CNc1nn2c(C)cc(COC)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H18N4O3S/c1-11-9-12(10-23-3)18-16-14(15(17-2)19-20(11)16)24(21,22)13-7-5-4-6-8-13/h4-9H,10H2,1-3H3,(H,17,19)
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0.269n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417917
PNG
(CHEMBL1668565 | US8618114, 1.2.6(1))
Show SMILES CNc1nn2c(CO)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)19-15(17-10)13(14(16-2)18-19)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
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0.282n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318625
PNG
(CHEMBL1083654 | N-Methyl-(3-phenylsulfonyl)-7,8-di...)
Show SMILES CNc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N4O2S/c1-17-15-14(23(21,22)12-7-3-2-4-8-12)16-18-10-11-6-5-9-13(11)20(16)19-15/h2-4,7-8,10H,5-6,9H2,1H3,(H,17,19)
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0.375n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM103506
PNG
(CHEMBL2172186 | US8552017, 1.1(3).HCl)
Show SMILES CNc1nn2c3CCN(C)Cc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H19N5O2S/c1-18-16-15(25(23,24)13-6-4-3-5-7-13)17-19-10-12-11-21(2)9-8-14(12)22(17)20-16/h3-7,10H,8-9,11H2,1-2H3,(H,18,20)
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US Patent
0.389n/a 0.837n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...


US Patent US8552017 (2013)


BindingDB Entry DOI: 10.7270/Q2R49PDW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM103506
PNG
(CHEMBL2172186 | US8552017, 1.1(3).HCl)
Show SMILES CNc1nn2c3CCN(C)Cc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H19N5O2S/c1-18-16-15(25(23,24)13-6-4-3-5-7-13)17-19-10-12-11-21(2)9-8-14(12)22(17)20-16/h3-7,10H,8-9,11H2,1-2H3,(H,18,20)
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0.390n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in HeLa cells after 120 mins


Bioorg Med Chem Lett 22: 4273-80 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.036
BindingDB Entry DOI: 10.7270/Q2VH5PZ8
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417920
PNG
(CHEMBL1668592 | US8829009, 1.1(3))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-8-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-11(16)5-7-12/h4-8H,1-3H3,(H,17,19)
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0.398n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318627
PNG
(CHEMBL1083075 | N,5-Dimethyl-3-(phenylsulfonyl)-7,...)
Show SMILES CNc1nn2c3CCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-11-13-9-6-10-14(13)21-17(19-11)15(16(18-2)20-21)24(22,23)12-7-4-3-5-8-12/h3-5,7-8H,6,9-10H2,1-2H3,(H,18,20)
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0.413n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314762
PNG
(5-methyl-2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9...)
Show SMILES CSc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)21-17(19-12)16(18(20-21)24-2)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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0.440 -54.3 0.948n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314762
PNG
(5-methyl-2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9...)
Show SMILES CSc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)21-17(19-12)16(18(20-21)24-2)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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0.440n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins


Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314759
PNG
(2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-c...)
Show SMILES CSc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-22-16-14(23(20,21)12-7-3-2-4-8-12)15-17-10-11-6-5-9-13(11)19(15)18-16/h2-4,7-8,10H,5-6,9H2,1H3
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0.458 -54.2 0.986n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314759
PNG
(2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-c...)
Show SMILES CSc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-22-16-14(23(20,21)12-7-3-2-4-8-12)15-17-10-11-6-5-9-13(11)19(15)18-16/h2-4,7-8,10H,5-6,9H2,1H3
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0.458n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins


Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417933
PNG
(CHEMBL1668588 | US8618114, 1.2.7(1))
Show SMILES CNc1nn2c(C)cc(CO)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)17-15-13(14(16-2)18-19(10)15)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
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0.479n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318628
PNG
(CHEMBL1083076 | N,5-Dimethyl-3-(phenylsulfonyl)-6,...)
Show SMILES CNc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c1-12-14-10-6-7-11-15(14)22-18(20-12)16(17(19-2)21-22)25(23,24)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3,(H,19,21)
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0.490n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318623
PNG
(CHEMBL1082761 | N-Methyl-3-(phenylsulfonyl)-5,6,7,...)
Show SMILES CNc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-14-10-6-5-7-12(14)11-21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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0.499n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417919
PNG
(CHEMBL1668591 | US8829009, 1.1(5))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
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0.501n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318623
PNG
(CHEMBL1082761 | N-Methyl-3-(phenylsulfonyl)-5,6,7,...)
Show SMILES CNc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-14-10-6-5-7-12(14)11-21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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0.542n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314760
PNG
(2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9-tetrahyd...)
Show SMILES CSc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H17N3O2S2/c1-23-17-15(24(21,22)13-8-3-2-4-9-13)16-18-11-12-7-5-6-10-14(12)20(16)19-17/h2-4,8-9,11H,5-7,10H2,1H3
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US Patent
0.549 -53.7 1.18n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314760
PNG
(2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9-tetrahyd...)
Show SMILES CSc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H17N3O2S2/c1-23-17-15(24(21,22)13-8-3-2-4-9-13)16-18-11-12-7-5-6-10-14(12)20(16)19-17/h2-4,8-9,11H,5-7,10H2,1H3
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0.549n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins


Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417904
PNG
(CHEMBL1668568 | US8618114, 1.1.6(1))
Show SMILES CSc1nn2c(CO)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O3S2/c1-10-8-11(9-19)18-14(16-10)13(15(17-18)22-2)23(20,21)12-6-4-3-5-7-12/h3-8,19H,9H2,1-2H3
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0.562n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50449636
PNG
(BRL-43694 | GRANISETRON | Kytril | LY-278584 | San...)
Show SMILES [H][C@]12CCC[C@]([H])(C[C@H](C1)NC(=O)c1nn(C)c3ccccc13)N2C |r,TLB:24:23:8.9.7:2.4.3|
Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13-,14+
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0.600n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex


J Med Chem 41: 311-7 (1998)


Article DOI: 10.1021/jm9705418
BindingDB Entry DOI: 10.7270/Q2N29XMV
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417936
PNG
(CHEMBL1668596 | US8829009, 1.1(9))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H14ClFN4O2S/c1-8-6-9(2)21-15(19-8)13(14(18-3)20-21)24(22,23)10-4-5-12(17)11(16)7-10/h4-7H,1-3H3,(H,18,20)
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0.603n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM103505
PNG
(CHEMBL2172193 | US8552017, 2(4).HCl)
Show SMILES CNc1nn2c(C)c3CN(C)CCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H21N5O2S/c1-12-14-11-22(3)10-9-15(14)20-18-16(17(19-2)21-23(12)18)26(24,25)13-7-5-4-6-8-13/h4-8H,9-11H2,1-3H3,(H,19,21)
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0.660n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in HeLa cells after 120 mins


Bioorg Med Chem Lett 22: 4273-80 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.036
BindingDB Entry DOI: 10.7270/Q2VH5PZ8
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM103505
PNG
(CHEMBL2172193 | US8552017, 2(4).HCl)
Show SMILES CNc1nn2c(C)c3CN(C)CCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H21N5O2S/c1-12-14-11-22(3)10-9-15(14)20-18-16(17(19-2)21-23(12)18)26(24,25)13-7-5-4-6-8-13/h4-8H,9-11H2,1-3H3,(H,19,21)
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US Patent
0.662n/a 1.43n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...


US Patent US8552017 (2013)


BindingDB Entry DOI: 10.7270/Q2R49PDW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314763
PNG
(9-methyl-2-(methylthio)-3-(phenylsulfonyl)-5,6,7,8...)
Show SMILES CSc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)19-17-16(18(24-2)20-21(12)17)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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US Patent
0.680 -53.2 1.46n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50314763
PNG
(9-methyl-2-(methylthio)-3-(phenylsulfonyl)-5,6,7,8...)
Show SMILES CSc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)19-17-16(18(24-2)20-21(12)17)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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0.680n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins


Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM103507
PNG
(CHEMBL2172187 | US8552017, 1.1(4).HCl)
Show SMILES CNc1nn2c3CCN(C)Cc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H21N5O2S/c1-12-14-11-22(3)10-9-15(14)23-18(20-12)16(17(19-2)21-23)26(24,25)13-7-5-4-6-8-13/h4-8H,9-11H2,1-3H3,(H,19,21)
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0.680n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in HeLa cells after 120 mins


Bioorg Med Chem Lett 22: 4273-80 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.036
BindingDB Entry DOI: 10.7270/Q2VH5PZ8
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM103507
PNG
(CHEMBL2172187 | US8552017, 1.1(4).HCl)
Show SMILES CNc1nn2c3CCN(C)Cc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H21N5O2S/c1-12-14-11-22(3)10-9-15(14)23-18(20-12)16(17(19-2)21-23)26(24,25)13-7-5-4-6-8-13/h4-8H,9-11H2,1-3H3,(H,19,21)
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US Patent
0.685n/a 1.48n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...


US Patent US8552017 (2013)


BindingDB Entry DOI: 10.7270/Q2R49PDW
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417906
PNG
(CHEMBL1668571 | US8552005, 1.1(11))
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O2S2/c1-9-7-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-5-11(16)8-12/h4-8H,1-3H3
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0.759n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM103504
PNG
(CHEMBL2172192 | US8552017, 2(7).HCl)
Show SMILES CNc1nn2cc3CN(C)CCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H19N5O2S/c1-18-16-15(25(23,24)13-6-4-3-5-7-13)17-19-14-8-9-21(2)10-12(14)11-22(17)20-16/h3-7,11H,8-10H2,1-2H3,(H,18,20)
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0.820n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in HeLa cells after 120 mins


Bioorg Med Chem Lett 22: 4273-80 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.036
BindingDB Entry DOI: 10.7270/Q2VH5PZ8
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50358774
PNG
(CHEMBL1642114 | Ro-657674)
Show SMILES CSc1nn2c(N3CCNCC3)c3CCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H23N5O2S2/c1-28-19-17(29(26,27)14-6-3-2-4-7-14)18-22-16-9-5-8-15(16)20(25(18)23-19)24-12-10-21-11-13-24/h2-4,6-7,21H,5,8-13H2,1H3
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0.850n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation


J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50318634
PNG
(CHEMBL1084244 | N-methyl-3-(phenylsulfonyl)-8-(pip...)
Show SMILES O=S(=O)(c1cnn2c(N3CCNCC3)c3CCCc3nc12)c1ccccc1
Show InChI InChI=1S/C19H21N5O2S/c25-27(26,14-5-2-1-3-6-14)17-13-21-24-18(17)22-16-8-4-7-15(16)19(24)23-11-9-20-10-12-23/h1-3,5-6,13,20H,4,7-12H2
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0.850n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to 5HT6 receptor


J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417907
PNG
(CHEMBL1668572 | US8552005, 1.1(9))
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C15H14FN3O2S2/c1-9-7-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-5-11(16)8-12/h4-8H,1-3H3
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1.07n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417918
PNG
(CHEMBL1668589 | US8618114, 1.2.1(4))
Show SMILES CNc1nn2cccnc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C13H11ClN4O2S/c1-15-12-11(13-16-6-3-7-18(13)17-12)21(19,20)10-5-2-4-9(14)8-10/h2-8H,1H3,(H,15,17)
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1.17n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340726
PNG
(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3
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1.20n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340726
PNG
(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3
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1.20n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50014407
PNG
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
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1.40n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex


J Med Chem 41: 311-7 (1998)


Article DOI: 10.1021/jm9705418
BindingDB Entry DOI: 10.7270/Q2N29XMV
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50358776
PNG
(CHEMBL1922716)
Show SMILES CNc1cc(ccc1S(=O)(=O)c1cccc(F)c1)N1CCCNCC1
Show InChI InChI=1S/C18H22FN3O2S/c1-20-17-13-15(22-10-3-8-21-9-11-22)6-7-18(17)25(23,24)16-5-2-4-14(19)12-16/h2,4-7,12-13,20-21H,3,8-11H2,1H3
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1.40n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation


J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
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