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Compile Data Set for Download or QSAR

Found 102 hits with Last Name = 'connors' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50275934
PNG
((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2ncc(CO)s2)c1
Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-8-13(9-21)22-15/h3-8,21H,9H2,1-2H3,(H,17,19,20)
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4n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276015
PNG
(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nccs2)c1
Show InChI InChI=1S/C15H14N4S/c1-10-7-11(2)9-12(8-10)18-15-17-4-3-13(19-15)14-16-5-6-20-14/h3-9H,1-2H3,(H,17,18,19)
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8n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50275935
PNG
((S)-2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-...)
Show SMILES C[C@@H](CO)NC(=O)c1sc(nc1C)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r|
Show InChI InChI=1S/C20H23N5O2S/c1-11-7-12(2)9-15(8-11)24-20-21-6-5-16(25-20)19-23-14(4)17(28-19)18(27)22-13(3)10-26/h5-9,13,26H,10H2,1-4H3,(H,22,27)(H,21,24,25)/t13-/m0/s1
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9n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50275358
PNG
((2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyr...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-9-4-10(16(17,18)19)6-11(5-9)22-15-20-3-2-13(23-15)14-21-12(7-24)8-25-14/h2-6,8,24H,7H2,1H3,(H,20,22,23)
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10n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276065
PNG
((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1
Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)
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10n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276018
PNG
(1-(3-(cyclopenta-1,3-dienyl)benzyl)-3,5-diethylben...)
Show SMILES COc1cc(Nc2nccc(n2)-c2nccs2)cc(OC)c1
Show InChI InChI=1S/C15H14N4O2S/c1-20-11-7-10(8-12(9-11)21-2)18-15-17-4-3-13(19-15)14-16-5-6-22-14/h3-9H,1-2H3,(H,17,18,19)
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14n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249284
PNG
(2-(4-methyl-2-(2-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1nc(sc1CCO)-c1ccnc(Nc2cc(C)cc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C18H17F3N4OS/c1-10-7-12(18(19,20)21)9-13(8-10)24-17-22-5-3-14(25-17)16-23-11(2)15(27-16)4-6-26/h3,5,7-9,26H,4,6H2,1-2H3,(H,22,24,25)
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22n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50275357
PNG
(CHEMBL451450 | N-(3-methoxy-5-(trifluoromethyl)phe...)
Show SMILES COc1cc(Nc2nccc(n2)-c2ncc(C)s2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-9-8-21-14(25-9)13-3-4-20-15(23-13)22-11-5-10(16(17,18)19)6-12(7-11)24-2/h3-8H,1-2H3,(H,20,22,23)
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23n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276064
PNG
(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)
Show SMILES Cc1cnc(s1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-9-12(3)21-15/h4-9H,1-3H3,(H,17,19,20)
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23n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249286
PNG
(3-(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trif...)
Show SMILES OCCCOc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O2S/c18-17(19,20)11-8-12(10-13(9-11)26-6-1-5-25)23-16-22-3-2-14(24-16)15-21-4-7-27-15/h2-4,7-10,25H,1,5-6H2,(H,22,23,24)
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26n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276016
PNG
(CHEMBL512319 | N-(3-methoxy-5-(trifluoromethyl)phe...)
Show SMILES COc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4OS/c1-23-11-7-9(15(16,17)18)6-10(8-11)21-14-20-3-2-12(22-14)13-19-4-5-24-13/h2-8H,1H3,(H,20,21,22)
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28n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249318
PNG
(2-(2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4...)
Show SMILES Cc1nc(sc1CCO)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C18H20N4OS/c1-11-8-12(2)10-14(9-11)21-18-19-6-4-15(22-18)17-20-13(3)16(24-17)5-7-23/h4,6,8-10,23H,5,7H2,1-3H3,(H,19,21,22)
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32n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50275355
PNG
((2-(2-(3-methoxy-5-(trifluoromethyl)phenylamino)py...)
Show SMILES COc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2S/c1-25-12-5-9(16(17,18)19)4-10(6-12)22-15-20-3-2-13(23-15)14-21-11(7-24)8-26-14/h2-6,8,24H,7H2,1H3,(H,20,22,23)
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33n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276017
PNG
(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trifluo...)
Show SMILES Oc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H9F3N4OS/c15-14(16,17)8-5-9(7-10(22)6-8)20-13-19-2-1-11(21-13)12-18-3-4-23-12/h1-7,22H,(H,19,20,21)
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44n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50275356
PNG
(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Show SMILES OCc1csc(n1)-c1ccnc(Nc2cc(O)cc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N4O2S/c16-15(17,18)8-3-9(5-11(24)4-8)21-14-19-2-1-12(22-14)13-20-10(6-23)7-25-13/h1-5,7,23-24H,6H2,(H,19,21,22)
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50n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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56n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50276063
PNG
(4-(thiazol-2-yl)-N-m-tolylpyrimidin-2-amine | CHEM...)
Show SMILES Cc1cccc(Nc2nccc(n2)-c2nccs2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-3-2-4-11(9-10)17-14-16-6-5-12(18-14)13-15-7-8-19-13/h2-9H,1H3,(H,16,17,18)
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82n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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100n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249416
PNG
(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4S/c1-9-6-10(15(16,17)18)8-11(7-9)21-14-20-3-2-12(22-14)13-19-4-5-23-13/h2-8H,1H3,(H,20,21,22)
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110n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50249258
PNG
(CHEMBL475570 | N-(2,5-dimethylphenyl)-4-(thiazol-2...)
Show SMILES Cc1ccc(C)c(Nc2nccc(n2)-c2nccs2)c1
Show InChI InChI=1S/C15H14N4S/c1-10-3-4-11(2)13(9-10)19-15-17-6-5-12(18-15)14-16-7-8-20-14/h3-9H,1-2H3,(H,17,18,19)
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153n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249540
PNG
((R)-2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-...)
Show SMILES C[C@H](CO)NC(=O)c1sc(nc1C)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r|
Show InChI InChI=1S/C20H23N5O2S/c1-11-7-12(2)9-15(8-11)24-20-21-6-5-16(25-20)19-23-14(4)17(28-19)18(27)22-13(3)10-26/h5-9,13,26H,10H2,1-4H3,(H,22,27)(H,21,24,25)/t13-/m1/s1
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210n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50275935
PNG
((S)-2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-...)
Show SMILES C[C@@H](CO)NC(=O)c1sc(nc1C)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r|
Show InChI InChI=1S/C20H23N5O2S/c1-11-7-12(2)9-15(8-11)24-20-21-6-5-16(25-20)19-23-14(4)17(28-19)18(27)22-13(3)10-26/h5-9,13,26H,10H2,1-4H3,(H,22,27)(H,21,24,25)/t13-/m0/s1
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240n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50275934
PNG
((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2ncc(CO)s2)c1
Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-8-13(9-21)22-15/h3-8,21H,9H2,1-2H3,(H,17,19,20)
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270n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50276018
PNG
(1-(3-(cyclopenta-1,3-dienyl)benzyl)-3,5-diethylben...)
Show SMILES COc1cc(Nc2nccc(n2)-c2nccs2)cc(OC)c1
Show InChI InChI=1S/C15H14N4O2S/c1-20-11-7-10(8-12(9-11)21-2)18-15-17-4-3-13(19-15)14-16-5-6-22-14/h3-9H,1-2H3,(H,17,18,19)
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318n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50276064
PNG
(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)
Show SMILES Cc1cnc(s1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-9-12(3)21-15/h4-9H,1-3H3,(H,17,19,20)
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348n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50276064
PNG
(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)
Show SMILES Cc1cnc(s1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-9-12(3)21-15/h4-9H,1-3H3,(H,17,19,20)
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410n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50276015
PNG
(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nccs2)c1
Show InChI InChI=1S/C15H14N4S/c1-10-7-11(2)9-12(8-10)18-15-17-4-3-13(19-15)14-16-5-6-20-14/h3-9H,1-2H3,(H,17,18,19)
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419n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50249286
PNG
(3-(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trif...)
Show SMILES OCCCOc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O2S/c18-17(19,20)11-8-12(10-13(9-11)26-6-1-5-25)23-16-22-3-2-14(24-16)15-21-4-7-27-15/h2-4,7-10,25H,1,5-6H2,(H,22,23,24)
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422n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50276065
PNG
((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1
Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)
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450n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50249318
PNG
(2-(2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4...)
Show SMILES Cc1nc(sc1CCO)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C18H20N4OS/c1-11-8-12(2)10-14(9-11)21-18-19-6-4-15(22-18)17-20-13(3)16(24-17)5-7-23/h4,6,8-10,23H,5,7H2,1-3H3,(H,19,21,22)
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560n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249226
PNG
(CHEMBL513985 | N-(3-phenoxyphenyl)-4-(thiazol-2-yl...)
Show SMILES N(c1cccc(Oc2ccccc2)c1)c1nccc(n1)-c1nccs1
Show InChI InChI=1S/C19H14N4OS/c1-2-6-15(7-3-1)24-16-8-4-5-14(13-16)22-19-21-10-9-17(23-19)18-20-11-12-25-18/h1-13H,(H,21,22,23)
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630n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50249286
PNG
(3-(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trif...)
Show SMILES OCCCOc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O2S/c18-17(19,20)11-8-12(10-13(9-11)26-6-1-5-25)23-16-22-3-2-14(24-16)15-21-4-7-27-15/h2-4,7-10,25H,1,5-6H2,(H,22,23,24)
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677n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50275356
PNG
(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Show SMILES OCc1csc(n1)-c1ccnc(Nc2cc(O)cc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N4O2S/c16-15(17,18)8-3-9(5-11(24)4-8)21-14-19-2-1-12(22-14)13-20-10(6-23)7-25-13/h1-5,7,23-24H,6H2,(H,19,21,22)
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680n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50275358
PNG
((2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyr...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-9-4-10(16(17,18)19)6-11(5-9)22-15-20-3-2-13(23-15)14-21-12(7-24)8-25-14/h2-6,8,24H,7H2,1H3,(H,20,22,23)
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750n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50276017
PNG
(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trifluo...)
Show SMILES Oc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H9F3N4OS/c15-14(16,17)8-5-9(7-10(22)6-8)20-13-19-2-1-11(21-13)12-18-3-4-23-12/h1-7,22H,(H,19,20,21)
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754n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50276018
PNG
(1-(3-(cyclopenta-1,3-dienyl)benzyl)-3,5-diethylben...)
Show SMILES COc1cc(Nc2nccc(n2)-c2nccs2)cc(OC)c1
Show InChI InChI=1S/C15H14N4O2S/c1-20-11-7-10(8-12(9-11)21-2)18-15-17-4-3-13(19-15)14-16-5-6-22-14/h3-9H,1-2H3,(H,17,18,19)
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862n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50249416
PNG
(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4S/c1-9-6-10(15(16,17)18)8-11(7-9)21-14-20-3-2-12(22-14)13-19-4-5-23-13/h2-8H,1H3,(H,20,21,22)
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891n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50276017
PNG
(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trifluo...)
Show SMILES Oc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H9F3N4OS/c15-14(16,17)8-5-9(7-10(22)6-8)20-13-19-2-1-11(21-13)12-18-3-4-23-12/h1-7,22H,(H,19,20,21)
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991n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50275355
PNG
((2-(2-(3-methoxy-5-(trifluoromethyl)phenylamino)py...)
Show SMILES COc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2S/c1-25-12-5-9(16(17,18)19)4-10(6-12)22-15-20-3-2-13(23-15)14-21-11(7-24)8-26-14/h2-6,8,24H,7H2,1H3,(H,20,22,23)
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1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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1.03E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50276015
PNG
(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nccs2)c1
Show InChI InChI=1S/C15H14N4S/c1-10-7-11(2)9-12(8-10)18-15-17-4-3-13(19-15)14-16-5-6-20-14/h3-9H,1-2H3,(H,17,18,19)
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1.06E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50276064
PNG
(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)
Show SMILES Cc1cnc(s1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-9-12(3)21-15/h4-9H,1-3H3,(H,17,19,20)
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1.10E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50275357
PNG
(CHEMBL451450 | N-(3-methoxy-5-(trifluoromethyl)phe...)
Show SMILES COc1cc(Nc2nccc(n2)-c2ncc(C)s2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-9-8-21-14(25-9)13-3-4-20-15(23-13)22-11-5-10(16(17,18)19)6-12(7-11)24-2/h3-8H,1-2H3,(H,20,22,23)
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1.14E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50249416
PNG
(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4S/c1-9-6-10(15(16,17)18)8-11(7-9)21-14-20-3-2-12(22-14)13-19-4-5-23-13/h2-8H,1H3,(H,20,21,22)
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1.36E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50275356
PNG
(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Show SMILES OCc1csc(n1)-c1ccnc(Nc2cc(O)cc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N4O2S/c16-15(17,18)8-3-9(5-11(24)4-8)21-14-19-2-1-12(22-14)13-20-10(6-23)7-25-13/h1-5,7,23-24H,6H2,(H,19,21,22)
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1.50E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50275358
PNG
((2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyr...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-9-4-10(16(17,18)19)6-11(5-9)22-15-20-3-2-13(23-15)14-21-12(7-24)8-25-14/h2-6,8,24H,7H2,1H3,(H,20,22,23)
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1.50E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50249540
PNG
((R)-2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-...)
Show SMILES C[C@H](CO)NC(=O)c1sc(nc1C)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r|
Show InChI InChI=1S/C20H23N5O2S/c1-11-7-12(2)9-15(8-11)24-20-21-6-5-16(25-20)19-23-14(4)17(28-19)18(27)22-13(3)10-26/h5-9,13,26H,10H2,1-4H3,(H,22,27)(H,21,24,25)/t13-/m1/s1
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1.50E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50276063
PNG
(4-(thiazol-2-yl)-N-m-tolylpyrimidin-2-amine | CHEM...)
Show SMILES Cc1cccc(Nc2nccc(n2)-c2nccs2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-3-2-4-11(9-10)17-14-16-6-5-12(18-14)13-15-7-8-19-13/h2-9H,1H3,(H,16,17,18)
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1.55E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50276017
PNG
(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trifluo...)
Show SMILES Oc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H9F3N4OS/c15-14(16,17)8-5-9(7-10(22)6-8)20-13-19-2-1-11(21-13)12-18-3-4-23-12/h1-7,22H,(H,19,20,21)
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1.65E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50275358
PNG
((2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyr...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-9-4-10(16(17,18)19)6-11(5-9)22-15-20-3-2-13(23-15)14-21-12(7-24)8-25-14/h2-6,8,24H,7H2,1H3,(H,20,22,23)
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1.80E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
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